Cyclosporine Powder From GMP Factory In China

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Looking For GMP-Approved Cyclosporine Manufacturers In China?
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Why You Should Buy Cyclosporine Powder From Us?

#1. GMP/FDA approved:

Our Cyclosporin A is approved by China SFDA and US FDA, the whole sets of registration docs are ready.

WC is also avialable currently.

#2. Testing samples available:

You can get samples from us for your quality approval and registration in your MOH.

#3. Quality guarantee:

For any quality issues, you will get exchange of goods for free or you can receive full refund.

#4. Low MOQ:

Our moq starts at 1KG for tial orders. For lab researchers, we can also do 100G repacking.

#5. Short lead time:

compared to other GMP factories, our lead time is 1~2 days shorter.

What is Cyclosporine?

99% Cyclosporine With Best Quality

Cas number: 59865-13-3

Molecular formula: C62H111N11O12

Molecular weight: 1202.6 g/mol

As the main-stream immunosuppressant raw material, cyclosporine is s a white to off-white crystalline solid with a very weird skunk smell.

It is soluble in acetone and methanol, slightly soluble in water.

It is one of our GMP Approved APIs along with tacrolimus powder and sirolimus (Rapamycin).

Cyclosporine is a peptide with eleven amino acids.

People also call it ciclosporine, cyclosporin, and cyclosporin A, they are the same thing.

Doctors prescribe its tabs or caps for patients with organ transplants, as it can effectively reduce the activity of the patient’s immune system, so to lower the risks of organ rejections.

People also use it to treat rheumatoid arthritis, psoriasis, Crohn’s disease, nephrotic syndrome.

Cyclosporine is also made into eye drops relieve the symptoms of dry eyes.

What Is Cyclosporine Used For?

1. Immunosuppressive agents

Clinically cyclosporine is mainly used as the immunosuppressive agents for patients with transplant.

It is used to prevent the rejection of allogeneic kidney, liver, heart, bone marrow and other organs or tissues transplantation

Also it is used for the prevention and treatment of graft-versus-host reaction in bone marrow transplantation.

2. Treatment of Immune diseases

It is also used together with adrenocorticotropic hormone for the treatment of some immune diseases.

3. New explorations

in recent years, it has been reported to be used in the treatment of uveitis, heavy aplastic anemia and refractory autoimmune thrombocytopenic purpura, psoriasis, refractory lupus nephritis, etc.

Is Cyclosporine Dangerous?

#1. Safety issues as a chemical:

Chemically speaking, cyclosporine powder is tested and categorized as a very safe and common chemical to be shipped by air or by express. All the shipping companies such as FedEx, TNT, DHL and UPS are shipping it every day.

It is non poisonous and we can tell that by its LD50 value:

LD50 in rats by oral is 1480mg/kg

LD50 in mice by oral is 2803mg/kg

LD50 in rabbits is over 1000mg/kg.

It is neither flammable or explosive in any way.

Its flash point is 736.3°C and boiling point as 1293.8°C. It is relatively stable for heat. For more safety details, you can check its msds data below in download section.

#2. Side effects as a drug:

1. Nephrotoxicity:

One of the most severe side effects is nephrotoxicity, which might be related to the susceptibility of the individual.

It may affect renal function, decrease the ability of glomerular filtration rate, and cause high urine protein, urea nitrogen, and creatinine.

However, in most cases, it is transient and will recover after the drug is reduced and stopped.

But your are recommended to insist on regular follow-up visits during the medication period and do blood routine and liver and kidney function checks.

2. Hypertension:

After taking it, some patients will experience increased blood pressure and may even induce hypertension. Therefore, for elderly patients, it is necessary to pay close attention to this adverse reaction. If you have symptoms of high blood pressure, you need to take the medication carefully.

3. Cell carcinogenesis:

like other immunosuppressants, it will greatly increase the likelihood of developing lymphoma or other malignant tumors, which means it may cause cancer. During the period of taking the medication, patients need to avoid excessive exposure to ultraviolet light to avoid malignant skin lesions and incurable skin cancer.

4. Weight gain:

As one of immunosuppressive drugs, the patients may experience obesity after taking it. This is mainly due to the fact that these drugs are prone to water and sodium retention, and the body has symptoms of central obesity, which can be manifested as a round face and slender limbs, but the abdominal muscles are greatly increased.

5. Other side effects:

Other side effects may include increased body hair, gingival hyperplasia, paresthesia, and sometimes gastrointestinal disorders. In severe cases, it may also cause a series of concurrent diseases such as Raynaud’s syndrome, diabetes, and pancreatitis, and the number of white blood cells in the blood may also decrease.

To conclude: it is a common and safe chemical for shipment by air, while it will cause many unwanted side effects and it is better to take extra care when you are taking its medictions.

Cyclosporine vs Tacrolimus

cyclosporine vs tacrolimus

Those two are common drugs used for patients of transplantation to achieve adequate immunosuppression and to prevent acute rejection.

Below are their differences in details.

#1. Marketing period

Cyclosporine was discovered in 1971 and approved as immunosuppressant drugs for organ transplant rejection. Tacrolimus was not discovered till 1980s and not approved as drug for transplant rejections untill 1989.

#2. Danger to Kidney

Studies conducted by Nephrology Department, Hospital de Santo António, Porto, Portugal has shown that tacrolimus is less nephrotoxic. While tacrolimus showed easier blood pressure control but a higher chance to cause diabetes.

#3. Popularity

Studies have showed that tacrolimus is superior in terms of survival, graft loss, acute rejection, and steroid-resistant rejection in the first year. Tacrolimus is the most popular for maintenance immunosuppression after liver transplantation.

#4. Raw material cost

For both those pharm-grade APIs approved by Chinese SFDA, the tacrolimus price is much higher. The tacrolimus price of 100G is about 130usd/g, while the cyclosporine price is about 2500~3000usd/kg.

One is sold by GRAM, one is sold by KG. Tacrolimus is is just more expensive in terms of unit price.

What Is Cyclosporine's HS Code?

#1. API

For pure powder, it is an organic compound and a cyclic peptide with eleven amino acids.

Though it is used as an immunosuppressant, it is classified as one group of chemical compounds called other antibiotics with HS code as 2941909090 in China before Oct. 2020.

Currently it is categorized as other organic compounds with HS Code 2942000000. 

Speaking of 29420000, please pay close attention to the HS Code starting with 2942, it is very tricky and Chinese Customs are very strict and sensitive on it. There is one time that we declare our Propylthiouracil powder as 2942000000 (the correct hs code for propylthiouracil should be 2933599099.

Our goods are rejected from our customs for false HS declaration once. Later we had to declare it again to get it released from Shanghai airport.

#2. Finished Formulations

If you are importing its finished formulations, its HS code should be 3004909099, which means Other medicines in prescribed doses(其他已配定剂量的药品)

How Much Does Cyclosporine Cost?

For commericial order quantities with GMP&FDA approval, market price is about1600usd/kg as cnf by air.

For small order quantities of 1kg, our cost is around 2000usd/kg as door-to-door price by express or courier.

The cost is subject to stock status and raw material price change, contact us directly for its latest quote.

You can also check its India export prices listed on pharmacompass as below:

As you can see from the prices above, the average export price is 1600usd per kg, which is similar to ours.

But you know what, we can arrange fast shipment. Trust me on the lead time.

We also see the lowest offer is 1350usd per kilo, and this price is possible when old stocks need to be sold urgently.

Only in that case you would be able to get prices around 1300usd.

In other cases, watch out for quality issues by such a low price.

Where To Buy Cyclosporine Online?

#1. For formulation manufactuers

If you are a pharmaceutical manufacturer of finished formulations such as compounding capsules or tablets, our raw materials can meet your needs with GMP/DMF for your MOH registration and pilot manufacturing.

#2. For compounding pharmacies

If you are buying pure powder for pharmacy compounding, you are in the right places. We have happy pharmacy customers using our materials for years. We can persuade our GMP manufacturers to do repacking for order quantites less than their standard packing. If you contact GMP factory directly, that won’t be that easy and you will get a higher price for sure.

As we mentioned above, our cyclosporin is GMP approved, suitable for manufacturing human dosages. Also we make sure all the packing and transportation are meeting GMP requirements.

#3. For research institutions

If you are a researcher and you need it for research, check those prices from famous reagent companies below. The best price for it is from trc-Canada, 65usd/g for 5g. Other prices from sigma and mce are more expensive.

For whatever reason, you can leave us a message and we will do out best to deliver the first-tier goods with reasonable prices. You can contact us for a quote for comparison now.

Price from sigma is 310usd for 0.1g

Cost from trc-canada is 65usd/g for 5g

Unit price from mce 200usd for 0.5g

Where To Buy Cyclosporine For Dogs?

Atopic dermatitis is common in dogs and is associated with the production of IgE antibodies directed against environmental allergens.

Atopica is not recommended for use in bred dogs unless a veterinarian considers the risk-benefit ratio that is justified by the veterinarian.

Cyclosporine, also known under the brand name Atopica or Optimmune, is an immunosuppressant commonly used in dogs and cats to treat atopic dermatitis.

It is known for its anti-inflammatory properties, but is mainly used to treat atopic dermatitis and is one of the most common types of immuno-protective agents in the United States. 

If you need it to treat atopic dermatitis of your dogs, and you find the top brands are too expensive, it is better you find a local Vet clinics for dosage compoundings to lower your cost.

What is even better is: if your vet does not have the raw materials with good price, you can recommend us and we will send the samples directly to their clinics for you.

How To Ship and Store Cyclosporine Powder?

Cyclosporine powder is a very stable and safe chemical, not poisonous, not dangerous in any way such as flammable, explosive, oxidizing, etc. 

For urgent needs it is recommended to ship it by air or by express. But you can ship it according to your order quantity. If it is as big as 500kg, ship it by sea if you like.

But the most common ways are by air in our experience. Due to its high value, air freight is only a very small part of the total cost.

During the transportation it is not necessary to ship it with ice pad to keep it cool because the powder is stable in room temperature.

As for storage, it should be stored in a dry and secure place with inner package sealed well. Protected from light and heat. Make sure the storage temperature not over 25 degrees.

If you are storing a reference standard, you should put it into a refrigerator and store it under 20 degrees below 0.

Technical Documents Download


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