99% Tiopronin API Powder With GMP and Best Prices

Looking For 99% Tiopronin Powder For Your Compounding Pharmacy?
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Why You Import Bulk Tiopronin Powder From Us?

First: Strict GMP guidelines guarantee high quality.

The bulk powder is produced strictly according to cGMP guidelines. 

Therefore, this API is suitable for the production of finished dosages for human consumption.

Second: Steady supply with stable stock

Our standard stock quantity for it is 100~200 Kilos.

Stock status may slightly differ due to order quantities submitted by regular customers, but we make sure of the quick supply to the customers through our flexible production plans.

What is Tiopronin?

Tiopronin Chemical Structure

Cas Number: 1953-02-2

Chemical Formula: C5H9NO3S

Molecular Weight: 163.20

Chemical Name: 2-(2-sulfanylpropanoylamino)acetic acid.

HS Code: 2930909099 (Other organic sulfur compounds) (其他有机硫化合物)

Tiopronin, an acylated sulfhydryl-containing glycine derivative with reducing and complexing properties, is a white to off-white powder with its characteristic odor.

Of course, as an organic sulfur compound, it doesn’t smell good, at least not pleasant.

it is soluble in water or ethanol, and very slightly soluble in chloroform or ether.

As a carboxylic acid, it is readily soluble in dilute alkali solutions too.

Meanwhile, as a reducing compound, tiopronin quickly goes bad when exposed to high temperatures and sunlight.

It is a prescription thiol drug used primarily in treating severe homozygous cystinuria.

It breaks the disulfide bond of cystine and binds the sulfhydryl group of the resultant cysteine monomers to form a soluble tiopronin-cysteine-mixed disulfide, which is more water-soluble than cystine and is readily excreted.

This leads to a reduction in urinary cystine concentration and subsequently reduces cystine stone formation.

As a reducing compound with active sulfhydryl groups, it can also chelate heavy metals like NBMI, which has two functional mercapto groups with more potent reducing and chelating abilities.

What Testing Spectrums Are Available For Quality Control?

For Purity: HPLC or LC-Mass

We test its purity on every batch before they are released for export.

We need to make sure the quality is good before materials leave our warehouse.

Our purity requirement for our bulk tiopronin is 98.5% as min, normally the actual results will be over 99%.

For Structure: 1HNMR

We don’t test 1HNMR for every batch, but if you need it, we will test it for you.

As HPLC can also be used for identification with the comparison with the testing spectrum of RS, once the Retention Time of Peaks corresponds, it is the same material for sure.

Elemental Analysis:

We don’t normally do elemental analysis for this product, as it is not required by our SFDA or any other pharmacopeias.

If you have such requirements, we will test them in a third-party testing institution for you. 

How Much Does Tiopronin API Powder Cost?

If you are looking for pure tiopronin powder approved by China GMP to do compounding or manufacture medicines, please check our offer below:

For 50kilo, our FOB Shanghai/Beijing price is around 820USD per kilo.

For 100kilo, our FOB cost is about 800USD/kg.

For small business owners such as compounding pharmacies, our price for kilos is about 850~900usd per kilo including shipping cost by courier.

If you only need small quantities for scientific research, please contact us directly for a free quote.

Main Dosage Forms To Compound Tiopronin

  1. Tablets: 100mg
  2. Enteric tablets:100mg
  3. Enteric capsules: 100mg, 200mg
  4. Solutions for injection: 2ml/100mg, 2ml/200mg, 5ml/200mg
  5. Powder for injection: 100mg, 200mg

How To Ship Tiopronin Powder?

For the shipping options for bulk powder, you may want to limit it to shipping by air only.

First things first, it is proven to be a common/common chemical, not a dangerous one, so no hazardous packing is required.

As we mentioned above, tiopronin goes bad easily when it is exposed to high temperatures or sunlight, it is better to make the shipping period as short as possible, especially when it is summertime.

For wintertime, it is stable to ship it in plain drums without adding cooling agents.

You may also consider using freezers when your order quantity is way too big for shipping by air due to the high shipping cost.

If you need to know the general ideas of our shipping cost by couriers, it is something like below:

Shipping cost for starting 500G to North America/Europe: 50~60usd.

If you are ordering kilos, the shipping fee is around 40~50usd/kilo.

Shipping costs to Africa are the highest among all our export countries, please help to contact us directly for the updated prices of everything.

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