Source 99% Ergothioneine API of GMP Factory
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Ergothioneine Powder—often called the “longevity vitamin”—is the active ingredient behind a new generation of premium nutraceuticals, functional foods, and high-performance skincare.
As a naturally occurring sulfur-containing amino acid and thiourea derivative of histidine, Ergothioneine has emerged as one of the most powerful and scientifically validated antioxidants available today.
Unlike conventional antioxidants that are rapidly excreted, Ergothioneine is selectively accumulated and retained in cells for months via its specific transporter, OCTN1, and concentrates in tissues with the highest oxidative stress exposure—including the liver, kidney, brain, bone marrow, and eyes.
We don’t just supply Ergothioneine Powder. We deliver pharmaceutical-grade purity, documented regulatory compliance, supply chain reliability, and technical partnership that give you a competitive edge in this rapidly growing specialty ingredient market—whether you’re developing premium dietary supplements, functional foods, advanced skincare, or pharmaceutical formulations.
Why Choose Us Over Competitors?
1. Pharmaceutical-Grade Purity
We deliver Ergothioneine Powder with ≥98.0% purity (HPLC-verified), and≥99.0%–99.5% pharmaceutical-grade purity is available for premium formulations. Every batch undergoes rigorous quality control testing for identity, purity, specific rotation (≥+122°), heavy metals (≤10 ppm), microbial limits, and impurity profile. We maintain complete documentation of pharmacopeial and non-pharmacopeial impurities—a critical requirement for regulatory submissions.
2. GMP-Certified Manufacturing with Full Regulatory Support
Our manufacturing facilities operate under strict cGMP standards with ISO certification. Production is carried out using controlled microbial fermentation in accordance with cGMP pharmaceutical standards, ensuring consistent quality, full traceability, and reliable large-scale supply. We provide comprehensive documentation for regulatory submissions:
Certificate of Analysis (CoA) per ICH guidelines
Method of Analysis (MOA) documentation
Material Safety Data Sheet (MSDS) in GHS format
Stability data—accelerated and long-term
Complete impurity profile documentation
GMP certification from recognized regulatory authorities
HACCP, ISO, KOSHER, and FDA compliance documentation
3. Supply Chain Reliability at Scale
Scalable capacity—From gram-level samples to multi-ton commercial orders
Global logistics—Seamless shipping to the US, EU, Asia-Pacific, and beyond
Flexible packaging—1 kg/bag, 5 kg/bag, 25 kg/drum (customizable)
Inventory buffer—Large inventory maintained year-round
Rapid delivery—Samples shipped same day; bulk orders arranged within 72 hours
Competitive pricing—Cost advantages without compromising quality
Asia-Pacific production hub—Leveraging world-class manufacturing expertise in China
4. Technical Partnership for Formulation Success
The Ergothioneine market is expanding at a remarkable 28% CAGR. Success requires a partner who delivers more than just raw material. We help you win by providing:
Formulation optimization support for supplements, functional foods, and skincare
Regulatory guidance for FDA GRAS, novel food, and cosmetic registration
Analytical method development support
Custom particle size specifications to meet your formulation needs
Customizable delivery systems for enhanced bioavailability
Expert technical support from formulation scientists
Dedicated account management with rapid response
5. Compounding Pharmacy and Research Solutions
Small-order flexibility—Custom quantities for compounding and R&D applications
Purity you can trust—High-grade ingredients minimize cross-contamination risks
Technical guidance—Expert advice on storage, processing, and formulation
Reference standard availability—For analytical method development and quality control
Why Ergothioneine?
The OCTN-1 Transporter: Targeted Cellular Accumulation
Ergothioneine is not just another antioxidant that circulates in the bloodstream—it is actively transported into cells via the OCTN-1 transporter (ergothioneine transporter protein). This transporter is expressed at high levels in tissues with the greatest oxidative stress exposure—the liver, kidney, brain, bone marrow, and eyes. Once inside, Ergothioneine accumulates in the mitochondria and nucleus, protecting at the cellular level where damage is most critical.
Potent Free Radical Scavenging
Ergothioneine is a powerful scavenger of hydroxyl radicals (• OH), hypochlorous acid (HOCl), and other reactive oxygen species. It also functions as an inhibitor of iron- or copper-ion-dependent generation of OH from hydrogen peroxide (H₂O₂), preventing the formation of these damaging radicals in the first place.
NF-κB Inhibition and Anti-Inflammatory Action
Ergothioneine’s key anti-inflammatory mechanism involves inhibiting nuclear factor-kappa B (NF-κB) activation and interleukin-8 (IL-8) release in response to stimuli such as TNF-α and hydrogen peroxide. This makes it a powerful agent against chronic inflammation.
Anti-Aging and Skin Protection
Ergothioneine suppresses MMP-1 (a collagen-degrading enzyme), activates the Nrf2 antioxidant-response pathway, and reversibly inhibits tyrosinase. These mechanisms combine to protect against photoaging, reduce hyperpigmentation, and maintain skin barrier integrity.
Neuroprotection and Cognitive Health
Ergothioneine reaches the brain and exerts beneficial effects, including neurogenesis and neuronal maturation, positioning it as a promising agent for cognitive health and the prevention of neurodegenerative diseases.
Mitochondrial Protection
By accumulating in mitochondria, Ergothioneine protects these energy-producing organelles from oxidative damage, supporting cellular energy metabolism and physiological resilience.
Ergothioneine Powder Applications and Specifications
Manufacturer Documents Download
COA
Method Of Analysis By USP-NF2024
MSDS (Ask us for it if you need it)
Compounding Pharmacies
Addressing Your Pain Points:
Regulatory Compliance: Our ergothioneine is FDA-registered, USP/PhEur compliant, and backed by Certificates of Analysis (CoA).
Consistent Quality: 99.9% purity, batch-to-batch consistency for reliable patient outcomes.
Customization: Available in powder or liquid formats, with flexible MOQs (10g to 100kg).
Use Cases:
Neuroprotective supplements
Chronic inflammation therapies
IV nutrient formulations
Cosmetic Manufacturers
Addressing Your Pain Points:
Efficacy Claims: Clinically proven to reduce oxidative stress by 78% (linked to aging).
Formulation Stability: Vegan, non-GMO, and compatible with serums, creams, and sprays.
Market Differentiation: Position your brand as science-driven with “ergothioneine-powered” labeling.
Use Cases:
Anti-aging serums
Sunscreen boosters
Post-procedure recovery creams
Product Name: 99% Ergothioneine Powder (中文：麦角硫因)
Appearance: A white crystalline powder
Solubility: Soluble in water (10 mg/ml)
Cas Number: 497-30-3
Molecular Formula: C9H15N3O2S
Molecular Weight: 229.30 g/mol
Chemical Name: (2S)-3-(2-sulfanylidene-1,3-dihydroimidazol-4-yl)-2-(trimethylazaniumyl)propanoate
HS Code: 2934999099 (Other heterocyclic compounds-其他杂环化合物)
Suitability for shipment by air/sea/rail as common goods: suitable. It is safe to be shipped by air as common goods.
Grade: Pharmaceutical Grade/Food Grade/Cosmetic Grade
Purity or Assay: 99.0% as min (By HPLC)
Standards: Enterprise
Manufacturer Documents Available: GMP/ISO/COA/MSDS/SDS
Supply Capability: Over 1000 KG per month
MOQ: 1 KG
Bulk Ergothioneine Updated Price Ideas: Contact us by WhatsApp for more updated prices
Lead Time: 2~3 days for quantities less than 500 KG
Stock Status: Over 1000 KG
Shipping Temperature: Room temperature
Storage: Room temperature
FAQs About Ergothioneine Bulk Powder
What is Ergothioneine Powder used for?
Ergothioneine Powder is a naturally occurring sulfur-containing amino acid and potent antioxidant used as the active ingredient in premium nutraceuticals (anti-aging, cognitive health, immune support supplements), functional foods, advanced skincare (anti-aging, skin-brightening, barrier repair), and pharmaceutical formulations. It is often called the “longevity vitamin” due to its unique cellular protective properties.
What are the brand names for Ergothioneine?
Ergothioneine is the generic name for the active ingredient. It is also known by synonyms including L-(+)-Ergothioneine, EGT, 2-Mercaptohistidine betaine, Thioneine, Phytothioneine, and Ergothionin. It is the key active ingredient in numerous branded nutraceutical and cosmetic products.
What purity level do you guarantee for Ergothioneine Powder?
We guarantee ≥98.0% purity (HPLC-verified), with ≥99.0%–99.5% pharmaceutical-grade purity available for premium formulations. FDA GRAS notices have recognized purity levels of ≥99.9%. Every batch is tested for identity, purity, specific rotation (≥+122°), heavy metals (≤10 ppm), microbial limits, and quality parameters in accordance with USP, EP, and CP standards.
What documentation do you provide with each order?
Every shipment includes a Certificate of Analysis (CoA), Method of Analysis (MOA), Material Safety Data Sheet (MSDS), and stability data. For regulatory submissions, we provide complete manufacturing process documentation, quality certificates, and GMP documentation.
What is the recommended usage level of Ergothioneine?
Recommended usage levels vary by application: nutraceutical supplements typically contain 5–25 mg per serving; cosmetic formulations typically contain 0.1%–2.0%; functional foods follow GRAS-approved levels up to 150 mg/100 g for beverages and baked goods. The optimal concentration depends on the specific formulation and intended use.
What is the solubility and storage profile of Ergothioneine Powder?
Ergothioneine Powder is a white-to-off-white, water-soluble powder with a solubility of up to 10 mg/mL. It should be stored in cool, dry conditions in well-sealed containers, protected from light and moisture. It exhibits exceptional stability over a wide pH and thermal range, making it highly compatible with complex formulations. Shelf life is 2–3 years under appropriate storage conditions.
Is ergothioneine FDA-approved?
Ergothioneine has received FDA GRAS (Generally Recognized As Safe) recognition for use as a food ingredient. Multiple GRAS notices have been completed, including GRN 001270 (Gene III Biotechnology), GRN 001191 (Shanghai EGT Synbio), and GRN 734 (ErgoActive®). It is also approved for use in cosmetics across China, the US, and the EU, and as a novel food ingredient in the EU.
What makes Ergothioneine different from other antioxidants?
Unlike conventional antioxidants that are rapidly excreted, Ergothioneine is selectively accumulated and retained in cells for months via its specific transporter, OCTN1, and concentrates in mitochondria and the nucleus of high-stress tissues. It is also one of the few antioxidants that is non-irritating at cosmetic levels—”no acid chemistry, no retinoid-style turnover”.
Can you supply Ergothioneine Powder for compounding pharmacy applications?
Yes. We supply Ergothioneine Powder in quantities suitable for compounding pharmacies. Our powder can be used to formulate patient-specific nutraceutical and topical preparations.
What is your typical lead time?
Samples can be shipped on the same day. For bulk orders, logistics can be arranged within 72 hours. For standard quantities, the typical lead time is 3–5 days from stock.
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