Buy 99% Polymyxin B Sulfate Powder
Why You Buy Polymyxin B Sulfate Powder From Us?
#1. DMF/DML/Local GMP is available for your MOH registration directly. USDMF is under preparation.
#2. High quality standards: we stick strictly to USP40 or higher versions with on compromises on quality whatsoever.
#3. Low MOQ: though 1kg is our standard packing, we are willing to repack it smaller to cater your needs such as 1BOU, etc.
#4. Shorter lead time: tracking details can be provided to you within 3.5 days, this is 1.5 days shorter than average time needed by other suppliers.
#5. Quality guarantee: you will be fully refunded for any quality issues.
Looking For Polymyxin B Sulfate Manufacturers? Contact us now!
What Is Polymyxin B Sulfate?
Cas number: 1405-20-5
Molecular Formula: C56H100N16O17S
Molecular Weight: 1301.6 g/mol
It is a white to off-white powder derived from the bacterium Bacillus polymyxa. It is one of our strategic active pharmaceutical ingredients for dermal ointments.
It is easily soluble in water (50mg/mL) and stable in acidic solutions.It is almost insoluble in organic solvents such as ethers, ketones, esters, hydrocarbons, etc.
For example, its solubility in ethanol is 0.115 mg/mL. But it is a very hygroscopic chemical so you may want to handle it quickly to avoid leeching moistures from the air.
its neutral solution can be placed at room temperature for a week without affecting its potency. While its alkaline solution is unstable.
There are two types of Polymyxins: Polymyxin B and Polymyxin E(also known as colistin). Polymyxin B is composed of polymyxins B1, B1-I, B2, B3, and B6.
Polymyxins B1 and B2 are considered major components. These related components are structurally identical except for a different fatty acid group on each fraction.
Results from in vitro studies have shown marginal differences in MIC data when comparing the fractions.
Mechanism of Polymyxin B’s Bactericidal Effects is as below: Polymyxin B binds to the cell membrane and alters its structure, making it more permeable.
The resulting water uptake leads to cell death of bacteria. Polymyxin B is a cationic basic peptide that acts like detergent.
Polymyxin B can be used for urinary tract infections and meningitis as it exerts bactericidal effects against almost all Gram-negative bacilli except the Proteus and Neisseria genera.
What Is Polymyxin B Sulfate Used For?
Polymyxin B is an antibiotic against gram-negative bacilli, with bactericidal functions.
It has strong antibacterial effect on most of gram-negative bacilli.
It also very effective on Pseudomonas aeruginosa, E. coli, salmonella, dysentery bacillus, influenza bacillus, pertussis bacillus, gas-producing bacillus and pneumonia bacillus.
However, proteus amoebae is not sensitive to this product. Polymyxin B is effective against bacteria in both growth and stationary phases.
In the past, it was mainly used clinically to treat gram-negative bacterial infections, especially those caused by Pseudomonas aeruginosa and Escherichia coli, such as respiratory infections, peritonitis, bile duct infections, urinary tract infections, burn infections, ocular and corneal infections, and sepsis.
Gradually, it has been replaced by other antibiotics with better efficacy and lower toxicity. But it can still be used topically for infections of the eye, ear, skin and mucous membrane and Pseudomonas aeruginosa burns caused by sensitive bacteria.
#2. Mechanism of action
Its bactericidal working mechanism is to change the permeability of bacterial cells.
As a polypeptide antibiotic, it has extensive surface activity on baceterial cells.
Because Polymyxin B contains lipophilic functional groups (positively charged free amino groups), which can introduce lipoproteins, combine with phosphate in the cell membrane phospholipids, change the composition of the cytoplasmic membrane synthesized by bacteria, so as to increase the surface area of the cell membrane.
Then it will ruin the original shielding function of the cytoplasmic membrane and make the membrane much more permeable, resulting in the leakage of a large number of intracellular components, and finally causes the bacteria to die.
What is even better is that bacteria are less likely to develop resistance to polymyxin B.
What Are Polymyxin B Dosage Forms?
What Is The HS Code For Polymyxin B Sulfate Powder?
It belongs to the class of organic compounds known as polypeptides.
These are peptides containing ten or more amino acid residues.
But it is also an antibiotic.
In China it is classified as Other Antibiotics with HS Code as 2941909090 with supper class as Antibiotics.
How Much Does Polymyxin B Sulfate Powder Cost?
The price of pharm-grade type by commercial order quantities is about 4800~5000usd/kg as Fob Shanghai/Beijing.
This price above is for micronized polymyxin b powder. Price of plain powder should be cheaper.
For more accurate prices, please contact us directly.
You can also check its export and import prices from pharmacompass as below:
As you can see its import and export prices are around 5300usd per kg for quantities of 100 kilos.
This price is also the main-stream market prices and make sure you do not pay 6000 for 1 kilo.
How Do You Store and Ship Polymyxin B Sulfate Powder?
For long-term storage, polymyxin B sulfate powder as small samples should be stored under dark conditions at 2-8°C.
During our stability tests of room temperature, after three years of storage, we have not observed any change in the appearance of the samples. (Well sealed and protected from moisture and light)
If it is already dissolved into solutions, the solution should be filtered for sterilization and stored at 2-8°C. The solution is stable at 37°C for 5 days.
Polymyxin B has been testing by our authorities as a safe and common chemical to be shipped by air.
It is not poisonous. Check its acute toxicity data below:
Mice oral LD50: 790mg/kg
mice abdominal LD50: 20500ug/kg;
mice subcutaneous LD50: 59500ug/kg;
mice venous LD50: 5400ug/kg;
puppy intracerebral LDLo: 320ug/kg;
guinea pig subcutaneous LD50: 58mg/kg.
It is not flammable, explosive or oxidative, so it won’t cause any fires or explosions when you handle it properly. Therefore, there is no need for special packing materials. Common plastic bags and cartons are ok for the packing.
So you can ship it by air, by courier or by sea, totally upto you and your order quantity.
If you are worried about the possible potency loss, you can add ice bags during the transportation. But our stability has showed that it is ok for the stability if you ship it without any ice. Many customers have proved this point with their years of orders in the past.