Source 98% Pure SM-102 From GMP Factory
SM-102—also known as Lipid H, LNP-102, and Heptadecan-9-yl 8-((2-hydroxyethyl)(6-oxo-6-(undecyloxy)hexyl)amino)octanoate—is a synthetic ionizable amino-cationic lipid optimized for nucleic acid delivery.
Its chemical structure features an ionizable amine headgroup that is neutral at physiological pH (7.4) and becomes positively charged at acidic pH (e.g., within endosomes), thereby enabling efficient encapsulation of nucleic acids and facilitating endosomal escape.
SM-102 is available in multiple grades to support the entire development lifecycle:
Research Grade — for early-stage R&D and proof-of-concept studies
GLP Grade — for toxicology studies and preclinical development
GMP Grade — for clinical trials and commercial manufacturing
Excipient Grade — for approved pharmaceutical products
Why You Should Purchase SM-102 From Us?
#1. High purity:
Our purity, as measured by HPLC, is over 99%. To verify this, you can contact us for the latest testing spectrum.
Its clean, clear 1H NMR spectrum can also confirm its purity.
You can see it is very pure from the clear peaks of hydrogen groups, rather than being tangled with chaotic peaks.
#2. Better prices than most of the reagent companies:
There are many online vendors for it due to the COVID-19 outbreak; you can see the cost on their websites.
Online prices range from 4,000 USD to 6,000 USD per gram, even if you need 1 g.
Our price for 1G is less than 500 USD, and we can offer a wholesale price if you order 5 G or more.
What Is SM-102?
Cas No.: 2089251-47-6
Molecular Weight: 710.182 mol/g
Molecular Formula: C44H87NO5
Chemical Name: 9-Heptadecanyl 8-{(2-hydroxyethyl)[6-oxo-6-(undecyloxy)hexyl]amino}octanoate
SM-102 is a synthetic amino lipid we use to form lipid nanoparticles with other lipids.
SM-102 delivers mRNA-based vaccines, primarily serving as part of the drug-delivery system for the Moderna COVID-19 vaccine.
FAQs About Our SM-102
Q1: What is the primary pharmaceutical function of SM-102?
A: SM-102 is an ionizable cationic lipid. Its primary function is to serve as a critical structural and functional component in Lipid Nanoparticles (LNPs). It helps encapsulate the active pharmaceutical ingredient (API)—typically nucleic acids such as mRNA—and facilitates cellular uptake and endosomal escape, delivering the API into the cell’s cytoplasm, where it can function.
Q2: Is your SM-102 manufactured in accordance with cGMP guidelines?
A: Yes. Our SM-102 is produced in a facility that strictly adheres to current Good Manufacturing Practices (cGMP). This ensures the product’s quality and purity.
Q3: What documentation do you provide with each batch?
A: We provide a suite of documentation to support your quality and regulatory needs:
Certificate of Analysis (CoA): Details the results of all quality control tests for that specific batch, including purity, identity, and impurities.
Material Safety Data Sheet (MSDS/SDS): Provides information on safety, handling, and disposal.
Stability Data: Available upon request to support your own stability studies and shelf-life determinations.
Q4: We are an API importer. What are the key regulatory and logistical considerations?
A: We understand the complexities of international API and excipient import. We provide:
Complete Regulatory Documentation: All necessary paperwork for customs and regulatory bodies in your destination country.
Cold Chain Logistics: We specialize in shipping and handling temperature-sensitive materials, ensuring the product’s integrity upon arrival.
Batch-to-Batch Consistency: Our rigorous QC ensures that every shipment meets the same high standards, simplifying your import and quality-verification processes.
Q5: How does SM-102 integrate into a standard LNP formulation process?
A: SM-102 is typically used in combination with other lipids—such as DSPC (a phospholipid), Cholesterol (for stability), and PEG-lipid (for stealth and stability)—in an ethanol phase. This phase is then mixed with an aqueous buffer containing the nucleic acid (e.g., mRNA) using rapid mixing techniques (e.g., microfluidics or T-junction mixing) to spontaneously form stable LNPs. The precise molar ratio is formulation-dependent.
Q6: What is the typical molar ratio of SM-102 in an LNP formulation?
A: While the optimal ratio is specific to your formulation and target application, SM-102 is often used as the primary cationic lipid. A common starting point in many published formulations, such as those used in mRNA vaccines, is a molar ratio of approximately 50:10:38.5:1.5 (SM-102:DSPC:Cholesterol: PEG-lipid). We recommend a feasibility study to determine the ideal ratio for your specific API.
Q7: For compounding pharmacies, what are the handling and formulation considerations?
A: Compounding pharmacies using SM-102 must adhere to strict aseptic techniques.
Key considerations include:
Storage: Must be stored at -20°C, protected from light and moisture, to maintain stability.
Solubility: SM-102 is soluble in ethanol, a commonly used solvent in LNP preparation.
Documentation: Using a cGMP-grade material like ours ensures your compounded preparations meet the required purity and documentation standards, which are critical for patient safety and regulatory compliance.
Q8: What are the shelf life and recommended storage conditions?
A: The shelf life of our SM-102 is 24 months from the date of manufacture when stored unopened at -20°C ± 5°C under an inert atmosphere (e.g., nitrogen) and protected from light. We recommend avoiding repeated freeze-thaw cycles.
Q9: Do you offer custom lipid synthesis or formulation support?
A: While our core offering is high-purity, standard SM-102, we have the technical expertise to discuss custom projects. Please get in touch with our technical sales team to discuss your specific requirements for analog synthesis or formulation development support.
Q10: How do I request a sample, and what is the minimum order quantity (MOQ)?
A: We provide evaluation samples to qualified B2B customers. Please use the “Get Quick Quotes” button to submit your inquiry. A representative will contact you to discuss your needs, sample availability, and MOQ, which varies by packaging and destination.
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