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Why You Should Import Vancomycin Hydrochloride Powder From Us?

#1. Docs for registration are ready:

Our GMP/DMF are available for your MOH registration.

#2. Strict quality control:

Our pure powder meets the requirements of USP/EP

#3. Sample For Testing Are Available:

If you need samples for testing, contact us directly.

#4. Low MOQ:

Our MOQ is 1kilo. If you have less demand than that, we can also help to do the repacking into 100G.

#5. Short Lead time:

Goods will be shipped out within 4 days after order.

What is Vancomycin Hydrochloride?

Vancomycin Hydrochloride Structure

Cas Number: 1404-93-9

Molecular Weight:  1485.71g/mol

Molecular Formula: C66H76Cl3N9O24

HS Code: 2941909000

Vancomycin hydrochloride is a white to off-white crystal commonly used as an active ingredient for antibiotic injections.

It was a polypeptide firstly separated and made into injections by Eli Lily in 1958.

Vancomycin Hydrochloride is used to treat many life-threatening conditions caused by infections, to which those regular penicillins are not effective or for those people allergic to.

It is one of our China GMP-certified antibiotics along with Bacitracin, Spectinomycin Hydrochloride, Amphotericin B.

Vancomycin has a similar treatment efficacy of pseudomembranous colitis and Clostridium difficile-associated diarrhoea as Teicoplanin.

What Is Vancomycin Hydrochloride Used For?

The original purpose of developing vancomycin was to treat patients with infections caused by penicillin-resistant Staphylococcus aureus and patients who are allergic to penicillins.

For several reasons below, vancomycin has never been the first-line drug for the treatment of Staphylococcus aureus infections:

#1. Vancomycin is only administered intravenously because it will not be absorbed orally.

That’s why you see it is oral formulations but only injections.

#2. The rapid development of β-lactamase-resistant semisynthetic penicillins.

Penicillins such as methotrexate penicillin (and its successors such as etanercept (amine) penicillin, o-chloramphenicol, etc.) can effectively inhibit penicillin-resistant bacteria, therefore, it doesn’t leave much room for further development of vancomycin.

#3. If the vancomycin is not very pure, it was highly ototoxic and nephrotoxic.

These three findings above led to the downgrading of vancomycin as a “last line” anti-infective drug.

Vancomycin HCl considered as the Last Resort Remedy means it is only recommended when all other antibiotics are not effective to these infections anymore.

You can use vancomycin to treat serious, life-threatening infections by Gram-positive bacteria unresponsive to other antibiotics such as sepsis and lower respiratory tract, skin, and bone infections.

It has been used to treat many life-threatening infections in form of intravenous injections.

Those life-threatening infections include complicated skin infections, bloodstream infections, endocarditis, bone, and joint infections, and meningitis caused by methicillin-resistant Staphylococcus aureus.

Is Vancomycin A Penicillin?

As we mentioned earlier, vancomycin is a polypetide with a huge molecular weight of 1485.71g/mol.

It was developed to treat patients with infections allergic or non-reactive to penicillins.

Penicillin is an antibiotic extracted from Penicillium, and later it refers a class of antibiotics that contains penicillin in its molecule, which can destroy the cell wall of bacteria and play a bactericidal role during the reproduction period of bacterial cells.

Penicillin belongs to β-lactam antibiotics, which include penicillin, cephalosporins, carbapenems, monocyclics, cephalosporins, etc.

Though penicillin is a very commonly used antibacterial drug, an intradermal test must be performed to prevent allergy.

The penicillin category is below:

#1. Penicillin G class:

Such as penicillin G potassium, penicillin G sodium, long-acting cillin, etc.

#2. Semi-synthetic penicillins

2.1 Acid-resistant penicillin Penicillin V

2.2 Enzyme-resistant penicillins:

Such as benzathine penicillin (Neosporin II), chlorazolyl penicillin, etc.

2.3 Broad-spectrum penicillins:

Such as ampicillin, hydroxyampicillin (amoxicillin), etc.

2.4 Broad-spectrum penicillins against Pseudomonas aeruginosa:

Such as carbenzylpenicillin, oxybenzyl penicillin, furobenzylpenicillin, etc.

2.5 Azamethicillin (anti-Gram-negative bacillus penicillin):

Such as methicillin and its ester pimecillin, etc., which is characterized as more enzyme-resistant and effective against certain negative bacilli (e.g., Escherichia coli, Klebsiella and Salmonella), but poor against Pseudomonas aeruginosa.

By comparison we can conclude that vancomycin is not a penicillin but a polypeptide antibiotic to treat infections of some extreme cases.

How Much Does Vancomycin Hydrochloride Powder Cost?

If you are looking for pure powder approved with Chinse GMP to make injections or other forms of medicines, our cost for commercial order quantities of 100kg or more is around 850~900USD/KG.

Please note, there are two types available in the market: sterile and non-sterile type, also known as the injection-grade and topical grade(needs to be further sterilized).

For sterile type, the unit price is around 900USD per kilo, for non-sterile type, the price is lower, about 800usd each kg.

If you can accept a non-GMP source for your research, the related price offer should be around 500USD/KG.

Here we only supply pharma-grade powder with GMP.

For more accurate prices with other quantities, please contact us directly.

How To Ship and Store Vancomycin Hydrochloride Powder?

#1. Shipping methods

Vancomycin HCl powder is a common chemical suitable for shipping by courier, air, or sea.

We have the relevant certificate of safe air transportation issued by DGM.

No special packing materials are needed to pack it.

#2. Shipping Temperature

In the summertime, it is recommended to ship it with ice pads to keep the transportation temperature around 20 degrees celsius, at least keep it under 36 degrees.

While during spring and autumn, no ices are needed as long as the room temperature is not exceeding 20 degrees.

For shipping within a short period during winter, there is no need to add ice pads for the non-sterile grades.

To be safe, it is recommended to add ice for injection-grade materials.

#3. Storage

For short-term storage, 2~8 degrees Celsius are recommended.

It is requested to be sealed and protected from sunlight or moisture.

For long-term storage, -20 degrees Celsius are suggested.

Technical Documents Download

References

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