Looking For Pharmaceutical Excipients? Contact Us Now!

Why you should buy excipients from us?

#1. Our excipients are guaranteed with high quality by our steady manufacturing process, all our products are produced in GMP-certified workshops. Our excipients such as hydroxypropyl beta-cyclodextrin, beta-cyclodextrin, alpha-cyclodextrin, gamma-cyclodextrin, Betadex Sulfobutyl Ether Sodium, etc meet the requirements of USP and EP standards.

#2. Quality guarantee: If you are buying pharm-grade excipients from us, you are insured with quality guarantees. You will get a full refund or free exchange of goods for any quality issues. We will cover all the costs caused for quality issues such as import taxes, your margin as a distributor, etc.

#3. Competitive prices: We will make sure the price you get from us is no higher than our competitors, as we are working with the largest cyclodextrin manufacturers in Northern China. We can not 100% rule out the lower offers from smaller players in this industry.

#4. Lead time as promised: We always try to ship your goods as soon as possible and we will inform you in advance if there is any delay. In cases of busy seasons of manufacturing or shipping, we will keep our words to deliver your goods within the lead time agreed before your order. Or we will make it up to you either with a discount on the next order or a refund by cash.

What are excipients and how do we classify them?

excipients used in tablet manufacturing

Definition and classification:

Defination:

All materials in your medicine except the active pharmaceutical ingredients are excipients. We use excipients to give our medicines a form. Excipients also make sure our medicine is effective, stable, and safe to use. we will select excipients based on the API characteristics and the dosage forms.

You see all the contents of your pills on the leaflet, right? You exclude its active ingredients, all others are excipients.

Excipients are the basic materials and important components of pharmaceutical preparations. They are the basis where we make the medicine production and development possible. They play a key role in the formulation and production of pharmaceutical preparations. They gives our drug a dosage form, improve efficacy and reduce adverse reactions. We rely their quality and diversity to make more new dosage forms.

We have to use excipients as our API carriers, to improve drug stability and solubilization. We also need them for dosages of sustained and controlled release They are so important that they will greatly affect the drug quality and safety

Classification

There are more than 66 types of excipients used in our medicines. We can classify them by their sources, functions and usages as below.

#1. Source:

Natural, semi-natural and synthetic.

#2. Chemical structure

By chemical structure we can divide them into norganic and organic compounds.

Inorganic compounds include inorganic acids, inorganic salts, and inorganic bases. Organic compounds can be further divided into acids, bases, salts, alcohols, phenols, esters, ethers, celluloses, and sugars.

#3. Function and usages

①Injections: antioxidants, co-solvents and isotonic regulators.
②Oral solid preparations: lubricants, fillers, adhesives, diluents.
③Oral liquid preparations: dispersants, stabilizers and suspending agents.
④External medicines: anti-sticking agents, flavoring agents, propellants.

#4. Route of administration

Oral, injection, mucosal, transdermal or local administration, nasal or oral inhalation administration and eye administration.

Common excipients used for solid dosage manufacturing

Diluents

The diluent (or filler) is to fill the weight or volume of the tablet to facilitate tableting. The diameter of the tablet is generally not less than 6mm, and the weight is more than 100mg. If the main drug in the tablet is only a few milligrams or tens of milligrams, without adding appropriate fillers, we can not make them into tablets.

Common diluents include starch, sugar, dextrin, lactose, pregelatinized starch, microcrystalline cellulose, inorganic salts such as calcium sulfate, calcium hydrogen phosphate, and medicinal calcium carbonate.

Disintegrants

Disintegrant is a substance that quickly disintegrates the tablet into fine particles in our stomach.

Materials used as disintegrants are dry starch, sodium carboxymethyl starch (CMS-Na), substituted hydroxypropyl cellulose (L-HPC), crospovidone (PVP), effervescent disintegrant (on encountering water can produce carbon dioxide Gas acid-base system). The most commonly used acid-base system consists of citric acid or tartaric acid and sodium bicarbonate or sodium carbonate.

Wetting agents

Wetting agents are non-adhesive liquids to make other materials vicious by wetting them to make granules, they include distilled water, ethanol, etc.

Adhesives

Adhesive excipients include sugar powder and syrup, starch slurry, polyvinylpyrrolidone (PVP), cellulose derivatives (MMC, HPMC, CMC-Na, L-HPC, EC), gelatin slurry, dextrin.

Lubricants

Lubricant excipients include magnesium stearate, micronized silica gel, polyethylene glycol 400 and 6000, etc.

Absorbents

Absorbent excipients include light magnesium oxide, etc.