Pharma-Grade Excipients From GMP Manufacturers In China
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Why You Should Buy Excipients From Us?
#1. GMP-Manufacturing Workshops:
The quality of our excipients is made sure by our steady manufacturing process, all our products are produced in GMP-certified workshops.
#2. Competitive prices:
We will make sure the price you get from us is no higher than our competitors, as we are the largest cyclodextrin manufacturer in Northern China.
We can not rule out the lower offers from smaller players in this industry.
What Are Excipients?
All materials in your medicine except the active pharmaceutical ingredients are excipients.
We use excipients to give our medicines a form.
Excipients also make sure our medicine is effective, stable, and safe to use.
We will select excipients based on the API characteristics and the dosage forms.
You see all the contents of your pills on the leaflet, right?
You exclude its active ingredients, all others are excipients.
Excipients are the basic materials and important components of pharmaceutical preparations.
These excipients are the basis where we make medicine production and development possible.
You can say that they play a key role in the formulation and production of pharmaceutical preparations.
As the excipient gives our drug a dosage form with improved efficacy and reduced adverse reactions.
Plus, medicine manufacturers rely on excipients’ quality and diversity to make more new dosage forms.
Many types of excipients can be used as API carriers, to improve drug stability and solubilization.
We will also need certain excipients for dosages of sustained and controlled release.
These excipients are so important that they will greatly affect the drug quality and safety
There are more than 66 types of excipients used in our medicines.
We can classify them by their sources, functions, and usages as below.
Natural, semi-natural, and synthetic.
#2.2. Chemical structure
By chemical structure, we can divide them into inorganic and organic compounds.
Inorganic compounds include inorganic acids, inorganic salts, and inorganic bases.
Organic compounds can be further divided into acids, bases, salts, alcohols, phenols, esters, ethers, celluloses, and sugars.
#2.3. Function and usages
①Injections: antioxidants, co-solvents, and isotonic regulators.
②Oral solid preparations: lubricants, fillers, adhesives, diluents.
③Oral liquid preparations: dispersants, stabilizers, and suspending agents.
④External medicines: anti-sticking agents, flavoring agents, propellants.
#2.4. Route of administration
Oral, injection, mucosal, transdermal or local administration, nasal or oral inhalation administration, and eye administration.
Common Excipients For Medicine Manufacturing
The diluent (or filler) is to fill the weight or volume of the tablet to facilitate tableting.
The diameter of the tablet is generally not less than 6mm, and the weight is more than 100mg.
If the main drug in the tablet is only a few milligrams or tens of milligrams, without adding appropriate fillers, we can not make them into tablets.
Common diluents include starch, sugar, dextrin, lactose, pregelatinized starch, microcrystalline cellulose, inorganic salts such as calcium sulfate, calcium hydrogen phosphate, and medicinal calcium carbonate.
Disintegrant is a substance that quickly disintegrates the tablet into fine particles in our stomach.
Materials used as disintegrants are dry starch, sodium carboxymethyl starch (CMS-Na), substituted hydroxypropyl cellulose (L-HPC), and crospovidone (PVP), effervescent disintegrant (on encountering water can produce carbon dioxide Gas acid-base system).
The most commonly used acid-base system consists of citric acid or tartaric acid and sodium bicarbonate or sodium carbonate.
#3. Wetting agents
Wetting agents are non-adhesive liquids to make other materials vicious by wetting them to make granules, they include distilled water, ethanol, etc.
Adhesive excipients include sugar powder and syrup, starch slurry, polyvinylpyrrolidone (PVP), cellulose derivatives (MMC, HPMC, CMC-Na, L-HPC, EC), gelatin slurry, dextrin.
Lubricant excipients include magnesium stearate, micronized silica gel, polyethylene glycol 400 and 6000, etc.
Absorbent excipients include light magnesium oxide, etc.
This list can go on and one with more new molecules is developed