99% Betadex Sulfobutyl Ether Sodium In Stock
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Why You Should Buy SBECD From Us
#1. High quality:
Our quality is guaranteed by steady manufacturing procedures and strict quality control: our BSES powder is manufactured in a GMP-Standard factory. Our steady and innovative manufacturing process yields high-quality powder.
#2. low MOQ:
We have small packages in 100g, and 200g available for your trial orders.
#3. Samples available for testing:
If you are not sure of our quality and want to test our samples before formal order, we get you covered on this. Contact us directly so we can arrange the samples.
What is Betadex Sulfobutyl Ether Sodium(SBECD)?
Cas number: 182410-00-0
Molecular formula:
Molecular weight: 2242.0461 g/mol
HS Code: 3505100000
Other Names: b-Cyclodextrin sulfobutyl ether sodium salt, β-cyclodextrin sulfobutyl ether, Sulfobutylated beta-cyclodextrin sodium salt, SBECD, sbebcd.
Betadex sulfobutyl ether sodium is white to off-white crystalline powder.
It is one of the most popular excipients ever used in our pharmaceutical industries, especially for injections.
It is amorphous and hygroscopic.
It is freely soluble in water and slightly soluble in methanol, but insoluble in ethanol, ethyl acetate, and dichloromethane.
Its solubility in 100ml water is more than 50g, PH of its 30% water solution is 5.4~6.8.
It is an improved version of hydroxy beta-cyclodextrin, with better complexation performances and higher prices.
What Is SBECD Used For?
Sulfobutyl-β-cyclodextrin is an anionic cyclodextrin derivative with much better water solubility.
It will form a non-covalent complex with many insoluble APIs to optimize API properties.
It will make APIs more stable and more easily dissolved. It will also lower renal toxicity and reduce hemolysis.
We can also use it to control the drug-release rate, and cover odors and bitter tastes.
It shows biological activity similar to heparin with low nephrotoxicity, so it is widely used as a high-end injection carrier.
Studies have shown that about 40% of new APIs are insoluble in water and nearly 60% of all APIs have poor solubilities.
Due to the poor solubilities, clinical trials of new drugs are not good.
This poor water solubility has greatly slowed these new molecules from being approved as new drugs.
Therefore, many pharmaceutical manufacturers have used Sulfobutyl-β-cyclodextrin sodium widely to improve the solubility of poorly water-soluble APIs, thereby getting many new drugs approved.
When we mix docetaxel with sulfobutyl-β-cyclodextrin sodium by a molar ratio of 1:12, the solubility of docetaxel in water is increased by about 800 times, which provides a basis for the development of docetaxel water injections.
When we test the complexed compound of sodium calycetin and sulfobutyl-β-cyclodextrin sodium, its water solubility was increased by about 76 times.
After we mix Amiodarone and sulfobutyl-β-cyclodextrin sodium by a molar ratio of 1:2, the solubility of complexes in water is increased by 195 times.
In 2020 we have covid-19, Remdesivir is made into injections by combining Betadex sulfobutyl ether sodium.
Though it is a great injection carrier, no pharmaceutical company should abuse it.
Its max daily dosing is 320mg/kg according to scientific research.
How To Ship And Store SBECD Powder?
For the shipping of SBECD, you can ship it by sea if you are buying it in commercial order quantities.
For small quantities, we can ship it either by courier or by air for you.
It is a very safe chemical suitable to be shipped by air. Its certificate of safe air transportation is available.
During the transport, no ice bag or cold-chain storage is needed. It is stable under RT.
For storage of sulfobutyl-β-cyclodextrin, it has to be sealed well in an air-tight inner package and protected from the light.
Because it is hygroscopic and easy to draw moistures in the air, the water will tamper with its quality if not sealed well.
Though it is relatively stable, it is recommended to be stored in a firm container protected from heat and light.
You can store it under room temperature, make sure there is no big temperature fluctuation.
It has a shelf life of 2 years. Make sure you run tests before you use them.
How Much Does SBECD Cost?
If you need to buy its injection grade pure powder by commercial order quantities to manufacture injections, our Fob Shanghai/Beijing price is around 350~500USD/Kilo.
If you only need kilos to do pilot trials, our price is around 600usd per kg.
Now if you need several grams doing lab research and testing, we promise you the best quality at the lowest prices.
In case you are not sure if you are getting a reasonable price from us, you can check some of its online prices below:
SBECD cost from sigma is about 400usd per 500mg
sbebcd price from cymit is 421euros for 500mg
As you can those offers from reagent companies, their price for 0.5g is more than the cost of one kilo from us, not to mention the prices for grams.
If you don’t have sufficient budget or funds in your lab for it, give us a chance and you won’t regret it.