Bulk Amphotericin B Powder With The Best Price
Why You Should Buy Amphotericin B Powder From Us?
#0. You will have the best price you can ever find in China.
#1. GMP/DMF Available: Our powder-manufacturing line is approved by NMPA and our manufacturing is issued with a GMP certificate.
#2. Sample For Approval is Available: We have samples for your testing request if you need samples before order.
#3. Low MOQ: Sterile liposomal-injection-grade powderstarts at 1KG, but oral type starts at 100G. We provide smaller packages for your lab research.
If you are taking a standard package, 2 days.
#4. Both liposomal grade and non-sterile oral powder are available so you have more choices.
#5. Qualiy guarantee: 100% refund for any quality issues or free exchange of goods
Looking For Amphotericin B Manufacturers In China? Message Us Now!
What Is Amphotericin B?
Cas Number: 1397-89-3
Molecular Formula: C47H73NO17
Molecular Weight: 924.1 g/mol
HS Code: 2941909000
Amphotericin B is a yellow to orange powder used as an antibiotic. It is a polyene antifungal antibiotic produced by Streptomyces nodosus.
It is insoluble in water but easily soluble in lipids. It is one of our competitive pharmaceutical ingredients with China GMP.
It can bind to ergosterol to depolarize the membrane and alter cell membrane permeability. Important intracellular components will leak from cell to cause bacterial cell death.
As a broad-spectrum an antifungal agent, it has activity against many fungal species. Common side effects include mild to moderate serum aminotransferase elevations and hyperbilirubinemia, but very rare to see acute drug induced liver injury caused by it.
What Is Amphotericin B Used For?
Amphotericin B is a polyene antifungal antibiotic that inhibits fungal growth by affecting cell membrane permeability.
#1. Clinical treatment of fungi infections.
It is used clinically for the treatment of severe visceral or systemic infections caused by deep-seated fungi.
It is also indicated for the treatment of the following fungal infections: cryptococcosis, germinosis, disseminated candidiasis, coccidioidomycosis, histoplasmosis, trichinosis caused by Trichinella, Aspergillus, Platyhelminthes, Endocytosis, and Frogminthes, sporotrichosis caused by Schenk’s sporoplasmosis, and aspergillosis caused by Aspergillus fumigatus.
#2. Fungal detections.
Externally, it is used for coloring fungal diseases, post-burn skin fungal infections, respiratory Candida, Aspergillus or Cryptococcus infections, and fungal corneal ulcers.
Due to the apparent toxicity, doctors would need it for the diagnosis of established deep fungal infections (also known as culture or positive histological tests) in patients with critically ill and progressive disease.
#3. Cell cultivation in the lab
It is also used to prevent the cell culture contamination of yeast and multicellular fungi.
It changes the fungal plasma membrane permeability so the fungi will not grow there.
Caution: it is not allowed to be used in patients who have no obvious clinical signs of fungal infection but only showing positive skin or serum tests.
Below is an enducational video on its working mechanism.
Amphotericin B Side Effects
Its common side effects include fevers, chills, headaches, loss of appetite, nausea, vomiting, etc.
Intravenous medications could induce thrombophlebitis.
Intrathecal injections can cause pain in your back and lower limb.
It is toxic to kidney and can cause proteinuria and tubular urine.
Doctors have suggested to stop the medication When urea nitrogen is >20mg/dl or creatinine >3mg/dl.
Or you have to lower the dose according to the advice from your doctor.
Other side effects may include declining numbers of white blood cells; instability of anemia and blood pressure; liver damage; diplopia; peripheral neuritis; rash.
During the process of medication, some patients may experience accelerated heart rate or ventricular fibrillation.
Those symptoms are most likely related to the high dose or fast injection.
There are liposomal injections or lipid complexes available in the market to cause less side effects.
Those dosages can greatly improve its safety and efficacy.
How Much Does Amphotericin B Bulk Powder Cost?
For oral grade, commerical order quantities, our price is about 8000~10000 USD/kg as cnf by air.
For the cost of injection-grade type, our price is around 15000~22000usd per kilo.
We currently have injection-grade powder in stock for sale, contact us now for a quick order.
For smaller order quantities and more accurate costs, please contact us directly.
Due to small demand and rising costs of labor, environmental protection, its price has been on a rise since 2010.
Check its price trends below for your ref.
You can also check its export prices before 2016 from China to India as below.
There you can see the main-stream cost is around 7400 USD per Kilo.
How Do You Ship and Store Amphotericin B Powder?
Amphotericin b is very sensitive to light, make sure avoid direct sun-light during the transportation and storage.
Transport Conditions: It is a safe and common chemical. Not dangerous.
According to testing results from DGM, it is said as below:
According to IATA DGR Special Provision A3, it is classified as “Not Restricted, as per Special Provision A3”.
As an antitiotic, it is highly recommended to be shipped at low temperatures.
First thing first, there are two GRADES and three TYPES of amphotericin b powder for different dosage forms. shipping temperature and storage conditions are slightly different.
For Oral Grade or conventional type.
For conventional type, we can ship it by room temperature but store it under a temperature of 2~8 Degrees Celsius. please keep it sealed and protected from light and moisture during your storage.
If you want to weigh some during the storage, make sure the sample doesn’t absorb moisture. As we all know that a low-temperature chemical will draw moistures in the air. To avoid it:
1) you can weigh the sample after the whole package is back to room temperature naturally.
2) Weigh it under a moisture-free fume-hood if it is weighed under 2~8 degrees.
This type of powder is suitable to manufacture oral dosages and topical formulations, such as tablets, capsules, creams, emulsions, gels, ear drops, ointments, or some veterinary formulations.
For Injection Grades: (Liposomal type and non-liposomal type)
For the shipping and storage of injection-grade, especially the liposomal grade, you have to take extra precautions. You can not ship it by room temperature like conventional grade, but have to transport it by cold-chain shipping methods.
Estimate how many days it will take to deliver it, add enough ice bags to keep it cool, at the same temperature we store it, 2~8 Degrees Celsius.
Of all those three grades, the liposomal type is the most expensive one and it has the highest potency. We have to refine it by recrystallization at least twice to get it.