Buy Bacitracin Powder With The Best Price

Bacitracin Structure

Why Buy Bacitracin Powder From Us?

#1. High quality approval: Registered and approved by FDA

#2. GMP/DMF Available for foreign MOH registration

#3. High quality standards: Strictly meeting USP41 and EP6.0

#4. Quality Guarantee: Full refund for quality issues

#5. Sample for quality approval is available

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What Is Bacitracin Powder?

Cas number: 1405-87-4

Molecular formula: C66H102N17O16S

Molecular weight: 1421.68538

Bacitracin is a white to off-white fluffy powder and one of our China GMP-Approved APIs along with Bacitracin zinc, polymyxin b sulfate. It is soluble in water, ethanol, and pyridine. Its acidic or neutral aqueous solution is relatively stable. When pH maintains at 5-7, its solution is stable for 4 weeks. When solution pH is greater than 9, bacitracin could degrade rapidly at room temperature.

First isolated in 1945 and later commercially produced, it is a mixture of related polypeptides widely used as an antibiotic in injections or topical formulations.

It is a mixture of related compounds with different antibacterial activities. Components include compound A, A1, B, B1, B2, C, D, E, F, G, and X. Compound A was found to have the most antibacterial activity. Compound B1 and B2 have similar potencies and are approximately 90% as active as compound A. Other components including F and X do not appear to be extensively studied.

It is manufactured by growing the bacteria Bacillus subtilis var Tracy in a container of liquid growth medium in our FDA-audited facility. After fermentation, the bacteria synthesize the antibiotic and secrete the antibiotic into the medium. Then we extract it from the medium through chemical processing.

it is an effective narrow-spectrum polypeptide with an antibacterial spectrum similar to penicillin and effective against Gram-positive bacteria, some Gram-negative bacteria, spirochetes, and actinomycetes. These polypeptides inhibit Gram-positive bacteria by interfering with the cell wall and peptidoglycan synthesis.

What Are Bacitracin Related Ingredients?

As per Monographs in USP38-NF33 S2, it has 8 related ingredients: A, B1, B2, B3, C1, C2, C3, F, those are the impurities listed in USP. But according to wikipedia, it is made up by 11 components:A, A1, B, B1, B2, C, D, E, F, G  and X.

Bacitracin related ingredients

Among the 8 substances, 4 of them are active ingredients: A, B1, B2, B3. The rest of the ingredients are regarded as impurities such as Bacitracin C1, C2, C3, F.

How Is Bacitracin Powder Manufactured?

It is commercially manufactured by growing the bacteria Bacillus subtilis var Tracy I in a container of liquid growth medium. After a certain period, the bacteria synthesize the antibiotic and secrete the antibiotic into the medium. Then the antibiotic is extracted from the medium through chemical processes.

1. Fermentation: use Bacillus subtilis and B. licheniformis to get its solution. ( the solution is an extraction and separation solution of a Bacillus subtilis and a B-type Bacillus licheniformis fermentation broth with a potency of no less than 5000 u/ml and a conductance of less than 2000 μs/cm).

2. Adjusting PH value: an alkaline solution is added to its solution to adjust the pH as 8 to 11, adjust pH as 5 to 7 with an inorganic acid, stir for 1 to 2 hours, and let stand for 5 to 10 hours.

3. Extraction: it is then obtained by membrane separation, drying, pulverization, and sieving.
The spray-dried powder obtained by processing above can be used as pharmaceutical raw materials for medicine preparations such as injections and ontments with polmyxin b.

USP requires that the total content of compound A is no less than 40.0%, the total amount of A, B1. B2 and B3 should be greater than 70.0% and the potency is no less than 60IU/MG.

What Can Bacitracin Powder Be Used For?

It is used for human medicine as a polypeptide antibiotic against infections. Please note, it should only be used to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria.

It is primarily made into ointments as it is can cause kidney damage when it is taken orally.

It has been indicated in topical formulations for acute and chronic localized skin infections. It is also used intramuscularly for infantile streptococcal pneumonia and empyema. It is also formulated as an ointment with neomycin and polymyxin B as OTC.

Its ointment formulated with neomycin and polymyxin B along with hydrocortisone is indicated for the treatment of corticosteroid-responsive dermatoses with secondary infection.

It can also be used in pure form for those with allergies to the polymyxin B and neomycin components of the combination product.

It is also commonly used as an aftercare antibiotic on tattoos and circumcision. It is preferred over combination products such as Neosporin because of its fewer ingredients, which lowers the chances of an allergic reaction.

Although its allergic cross-reaction with sulfa drugs has been occasionally reported, bacitracin-containing topical preparations is a great alternative to silver sulfadiazine (Silvadene) for patients burnt with a sulfa allergy.

It has been used to distinguish Streptococcus pyogenes from other “strep” bacteria, with S. pyogenes being sensitive to bacitracin and others resistant. In this case, it is used to distinguish S. pyogenes from other β-hemolytic streptococci.

It is also used to distinguish Haemophilus influenza colonies amongst respiratory flora; since H. influenza is intrinsically resistant to it, colonies would form within the zone of inhibition.

Bacitracin vs Mupirocin

#1 Different Usages

Mupirocin is an antibacterial pseudomonic acid antibiotic produced by Pseudomonas fluorescens. It is mainly used for skin infections such as impetigo, other primary or secondary superficial skin infections, such as ecthyma, eczema, folliculitis, furunculosis, atopic dermatitis, epidermolysis bullosa, and minor wounds, burns or ulcers.

While bacitracin is used for infection-preventions, especially wounds on the skin such as cuts or burns. It is also used for infantile streptococcal pneumonia and empyema when used intramuscularly.

#2. Different working mechanism

Mupirocin works by preventing bacteria from growing. It inhibits protein synthesis in bacteria by binding to isoleucyl transfer RNA synthetase. While bacitracin is a powerful bacteria killer so it will prevent the wounds from infections.

#3 Different Dosage forms

There are mainly 4 dosage forms of Mupirocin: 1. Mupirocin Calcium Ointment 2. Mupirocin Cream 3. Mupirocin Nasal Ointment 4. Mupirocin Ointment. Dosage forms for bacitracin include bacitracin for injection, bacitracin ointment and bacitracin ophthalmic ointment.

As we can there are only topical dosage forms for mupirocin no mupirocin injections. Neither does Mupirocin have eye ointments while bacitracin has injections as well as ophthamic ointments. 

The reason that mupirocin can not be made into eye ointments is because: once mupirocin is applied to eyes, there will be severe symptoms such as burning, tearing. It will take days or even weeks for this uncomfortableness to disappear. (If contact with the eyes occurs, thoroughly wash eyes with water or go to a doctor immediately).

However, there is mupirocin ointment for intranasal use, while there are no bacitracin dosage forms suitable for intranasal uses.

#4 Different Costs

Unit price for mupirocin api is around 2000usd per kg, almost 3 times of that of bacitracin. 

It is the same case when they are made into formulations. Mupirocin formulations are also more expensive than that of bacitracin, check the price below: the lowest bactroban price is 320.38usd and the lowest price for bacitracin ointment is 50.83usd.

Conclusion: Mupirocin is more expensive and used for infections. Bacitracin is cheaper and used for infection-prevention. Mupirocin can not be used for eye infections but no problems for nose infections. Bacitracin has injections and can prevent your eyes from infections.

bactroban vs bacitracin

Bacitracin vs Neosporin

Differences between them as below:

#1 Number of active pharmaceutical ingredients

There are 3 active ingredients in neosporin: neomycin sulfate, bacitracin zinc and polymyxin b sulfate. While bacitracin ointment only contains bacitracin.

#2 Chances of allergy

More people are allergic to neosporin while no problem to bacitracin ointment. That’s because neosporin contains more active ingredients than bacitracin ointment, especially when neomycin within is prone to cause allergies. When people are allergic to neomycin sulfate and polymyxin b sulfate, they can only use bacitracin ointment for another try. Bacitracin has less chance to give you allergies. If you are allergic to bacitracin, you must be allergic to neosporin, that’s for sure.

#3 Bacteria Killing Range

Neosporin is a combination of antibiotics, so it has wider bacteria-killing range and better infection-preventing effect than bacitracin.

#4 Production process

Because bacitracin ointment only contains one active ingredient, the production process is relatively easier. Trust me, mixing all the 3 ingredients in neosporin evely is not an easy job. It takes longer to blend and the production process is more complicated.

#5 Price

As neosporin is a famous brand, it costs more than bacitracin ointment in many markets. Even when you compare neosporin with Triple Antibiotic containing the same active ingredients as neosporin, it still costs more.

What Is The HS Code For Bacitracin?

It belongs to the class of organic compounds known as polypeptides. 

These are peptides containing ten or more amino acid residues. It is classified as other antibiotics with HS Code as 2941909090 in China Customs.

If you are importing its finished dosages such as ointments, injections, related hs code should be 3004909090.

How Much Does Bacitracin Powder Cost? (Updated on 2020.09.01)

For commercial order quantities our price is about 700usd/kg as Fob Shanghai/Beijing. 

If you want to buy it by trial orders for 1kg, our price is around 850usd/kg for your ref.

Because cost of bulk powder is subject to its raw material price fluctuations, please contact us directly for the lastest price update.

How Do You Ship and Store Bacitracin Powder?

#1. Shipment

First of all, it is a very safe chemical to be shipped by air. It has been tested and regarded as a common chemical suitable for shipment by air, by express and by sea packed in normal packing materials. It is non-flammable, not dangerous, not poisonous etc.

As to how you want to ship the pure powder, it all depends its quality standards.

If you are buying injection-grade powder, you may want it to be shipped as fast as you can at low temperature. Shipping by air or by express is your best option, to rule out any possible high temperatures. Because injection-grade powder is more expensive than oral-grade types, you have good reasons to spend extra bucks on the shipping for it.

If you are procuring some bulk powder for research such as bacterial growth, you may ship it by express/courier, with or without ice pads as you like. Though normal-temperature shipment will not affect its activity too much, it is better you ship it at low temperature to make sure its potency.

#2. Storage

Bulk powder is relatively stable during the storage.

Our stability tests have shown that it is stable for at least 36 months when it is stored in a dry environment and protected from the sunlight at room temperature.

So you can store the powder according to the conditions above if you are storing it for topical formulations.

For storage of injection-grade powder, low-temperature storage is recommended.

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