FDA Approved Bacitracin Powder For Sale

Bacitracin Structure

Bacitracin Structure

GMP & DMF: Available

Standards: USP/EP

Sample for quality approval: Available

Standard Packing: 10kg/Carton

MOQ: 10kg 

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What is bacitracin?

Bacitracin is a white to off-white fluffy powder. It is one of our China GMP-Approved APIs along with Bacitracin zinc, polymyxin b sulfate. It is soluble in water, ethanol, and pyridine. Its acidic or neutral aqueous solution is relatively stable. When pH maintains at 5-7, the bacitracin solution is stable for 4 weeks. When solution pH is greater than 9, bacitracin could degrade rapidly at room temperature.

Bacitracin, first isolated in 1945 and later commercially produced, is a mixture of related polypeptides widely used as an antibiotic in injections or topical formulations.

It is a mixture of related compounds with different antibacterial activities. Components include bacitracin A, A1, B, B1, B2, C, D, E, F, G, and X. Bacitracin A was found to have the most antibacterial activity. Bacitracin B1 and B2 have similar potencies and are approximately 90% as active as bacitracin A. Other bacitracin components including F and X do not appear to be extensively studied.

Bacitracin is manufactured by growing the bacteria Bacillus subtilis var Tracy in a container of liquid growth medium in our FDA-audited facility. After fermentation, the bacteria synthesize the antibiotic and secrete the antibiotic into the medium. Then bacitracin is extracted from the medium through chemical processing.

Bacitracin is an effective narrow-spectrum polypeptide with an antibacterial spectrum similar to penicillin and effective against Gram-positive bacteria, some Gram-negative bacteria, spirochetes, and actinomycetes. These polypeptides inhibit Gram-positive bacteria by interfering with the cell wall and peptidoglycan synthesis.

Bacitracin related ingredients​

As per Bacitracin Monographs in USP38-NF33 S2, bacitracin has 8 related ingredients: Bacitrain A, B1, B2, B3, C1, C2, C3, F, those are the impurities listed in USP. But according to wikipedia, bacitracin is made up by 11 components:A, A1, B, B1, B2, C, D, E, F, G  and X.

Bacitracin related ingredients

Among the 8 substances, 4 of them are active ingredients: Bacitracin A, Bacitracin B1, Bacitracin B2, Bacitracin B3. The rest of the ingredients are regarded as impurities such as Bacitracin C1, C2, C3, F.

How is bacitracin produced?

Bacitracin is commercially manufactured by growing the bacteria Bacillus subtilis var Tracy I in a container of liquid growth medium. After a certain period, the bacteria synthesize the antibiotic and secrete the antibiotic into the medium. Then the antibiotic is extracted from the medium through chemical processes.

1. Fermentation: use Bacillus subtilis and B. licheniformis to get bacitracin solution. (Bacitracin solution is an extraction and separation solution of a Bacillus subtilis and a B-type Bacillus licheniformis fermentation broth with a potency of no less than 5000 u/ml and a conductance of less than 2000 μs/cm).

2. Adjusting PH value: an alkaline solution is added to the bacitracin solution to adjust the pH as 8 to 11, adjust pH as 5 to 7 with an inorganic acid, stir for 1 to 2 hours, and let stand for 5 to 10 hours.

3. Extraction: bacitracin is then obtained by membrane separation, drying, pulverization, and sieving.
The spray-dried bacitracin powder obtained by processing above can be used as a raw material for medicine preparations such as bacitracin injections and bacitracin polymyxin b ointments.

The total content of bacitracin A is no less than 40.0%, the total amount of bacitracin A, B1. B2 and B3 should be greater than 70.0% and the potency is no less than 60IU/MG.

What can bacitracin be used for?

Bacitracin is used for human medicine as a polypeptide antibiotic against infections. Please note, bacitracin should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria.

Bacitracin is primarily made into ointments as it is can cause kidney damage when used internally.

Bacitracin has been indicated in topical formulations for acute and chronic localized skin infections. It is also used intramuscularly for infantile streptococcal pneumonia and empyema. Bacitracin is also formulated as an ointment with neomycin and polymyxin B as OTC.

Bacitracin ointment formulated with neomycin and polymyxin B along with hydrocortisone is indicated for the treatment of corticosteroid-responsive dermatoses with secondary infection.

Bacitracin can also be used in pure form for those with allergies to the polymyxin B and neomycin components of the combination product.

Bacitracin is also commonly used as an aftercare antibiotic on tattoos and circumcision. It is preferred over combination products such as Neosporin because of its fewer ingredients, which lowers the chances of an allergic reaction.

Although bacitracin’s allergic cross-reaction with sulfa drugs has been occasionally reported, bacitracin-containing topical preparations is a great alternative to silver sulfadiazine (Silvadene) for burn patients with a sulfa allergy.

Bacitracin has been used to distinguish Streptococcus pyogenes from other “strep” bacteria, with S. pyogenes being sensitive to bacitracin and others resistant. In this case, bacitracin is used to distinguish S. pyogenes from other β-hemolytic streptococci.

Bacitracin can be made into testing kits to distinguish Streptococcus pyogenes from other “strep” bacteria, with S. pyogenes being sensitive to bacitracin and others resistant. In this case, bacitracin is used to distinguish S. pyogenes from other β-hemolytic streptococci.

Bacitracin is also used to distinguish Haemophilus influenza colonies amongst respiratory flora; since H. influenza is intrinsically resistant to bacitracin, colonies would form within the zone of inhibition.

Mupirocin vs bacitracin

Mupirocin vs bacitracin

#1 Different Usages

Mupirocin is an antibacterial pseudomonic acid antibiotic produced by Pseudomonas fluorescens. It is mainly used for skin infections such as impetigo, other primary or secondary superficial skin infections, such as ecthyma, eczema, folliculitis, furunculosis, atopic dermatitis, epidermolysis bullosa, and minor wounds, burns or ulcers.

While bacitracin is used for infection-preventions, especially wounds on the skin such as cuts or burns. It is also used for infantile streptococcal pneumonia and empyema when used intramuscularly.

#2. Different working mechanism

Mupirocin works by preventing bacteria from growing. It inhibits protein synthesis in bacteria by binding to isoleucyl transfer RNA synthetase. While bacitracin is a powerful bacteria killer so it will prevent the wounds from infections.

#3 Different Dosage forms

There are mainly 4 dosage forms of Mupirocin: 1. Mupirocin Calcium Ointment 2. Mupirocin Cream 3. Mupirocin Nasal Ointment 4. Mupirocin Ointment. Dosage forms for bacitracin include bacitracin for injection, bacitracin ointment and bacitracin ophthalmic ointment.

As we can there are only topical dosage forms for mupirocin no mupirocin injections. Neither does Mupirocin have eye ointments while bacitracin has injections as well as ophthamic ointments. 

The reason that mupirocin can’t be made into eye ointments is because: once mupirocin is applied to eyes, there will be severe symptoms such as burning, tearing. It will take days or even weeks for this uncomfortableness to disappear. (If contact with the eyes occurs, thoroughly wash eyes with water or go to a doctor immediately).

However, there is mupirocin ointment for intranasal use, while there are no bacitracin dosage forms suitable for intranasal uses.

#4 Different Costs

Unit price for mupirocin api is around 2000usd per kg, almost 3 times of that of bacitracin. 

It is the same case when they are made into formulations. Mupirocin formulations are also more expensive than that of bacitracin, check the price below: the lowest bactroban price is 320.38usd and the lowest price for bacitracin ointment is 50.83usd.

Conclusion: Mupirocin is more expensive and used for infections. Bacitracin is cheaper and used for infection-prevention. Mupirocin can’t be used for eye infections but no problems for nose infections. Bacitracin has injections and can prevent your eyes from infections.

bactroban vs bacitracin

Neosporin vs bacitracin

Differences between neosporin and bacitracin as below:

#1 Number of active pharmaceutical ingredients

There are 3 active ingredients in neosporin: neomycin sulfate, bacitracin zinc and polymyxin b sulfate. While bacitracin ointment only contains bacitracin.

#2 Chances of allergy

More people are allergic to neosporin while no problem to bacitracin ointment. That’s because neosporin contains more active ingredients than bacitracin ointment, especially when neomycin within is prone to cause allergies. When people are allergic to neomycin sulfate and polymyxin b sulfate, they can only use bacitracin ointment for another try. Bacitracin has less chance to give you allergies. If you are allergic to bacitracin, you must be allergic to neosporin, that’s for sure.

#3 Bacteria Killing Range

Neosporin is a combination of antibiotics, so it has wider bacteria-killing range and better infection-preventing effect than bacitracin.

#4 Production process

Because bacitracin ointment only contains one active ingredient, the production process is relatively easier. Trust me, mixing all the 3 ingredients in neosporin evely is not an easy job. It takes longer to blend and the production is more complicated.

#5 Price

As neosporin is a famous brand, neosporin price is higher than bacitracin ointment in many markets. Even when you compare neosporin with Triple Antibiotic containing the same active ingredients as neosporin, neosporin still costs more.

neosprorin vs bacitracin on price
neosporin vs triple antibiotic on Price

What are bacitracin side effects

Side Effects of bacitracin include but not limited to diarrhea, unusual urinating, blood in urine, painful urination and lower back pain.

Other bacitracin reactions include nausea, vomiting, mild skin rash, pain, burning or swelling where bacitracin is injected.

Bacitracin is contraindicated in individuals who have shown hypersensitivity to any of its components.

What is Bacitracin Class?

Bacitracin belongs to the class of organic compounds known as polypeptides. These are peptides containing ten or more amino acid residues. It is classified as other antibiotics with HS Code as 2941909090.

Direct parent: Polypeptides

Alternative Parents: Cyclic peptides / Glutamic acid and derivatives / Leucine and derivatives / Isoleucine and derivatives / N-acyl-alpha amino acids and derivatives / Macrolactams / Alpha amino acid amides / Thiazolecarboxamides / Imidazolyl carboxylic acids and derivatives / Benzene and substituted derivatives
Dicarboxylic acids and derivatives / N-acyl amines / Thiazolines / Heteroaromatic compounds / Secondary carboxylic acid amides / Amino acids / Primary carboxylic acid amides / Lactams / Azacyclic compounds / Carboxylic acids / Propargyl-type 1,3-dipolar organic compounds / Organopnictogen compounds / Carbonyl compounds / Organic oxides / Monoalkylamines / Hydrocarbon derivatives

Superclass: Organic Polymers

Kingdoms: Organic compounds

What is Bacitracin Price? (Last update 2019.12.06)

For commercial order quantities our pharm-grade bacitracin price is about 680usd/kg as Fob Shanghai/Beijing. 

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