99% S-Adenosyl-L-Methionine Of GMP Factory
Ademetionine (SAMe) is a critical but sensitive molecule. Our S-Adenosyl-L-Methionine Disulfate Tosylate salt form is specifically engineered to offer superior stability and reliability for your most demanding hepatoprotective, antidepressant, and nutraceutical products.
Optimized Stability: The unique disulfate-tosylate salt configuration provides exceptional protection against moisture- and heat-induced degradation, ensuring a longer shelf life and consistent potency in your final product.
Pharmaceutical Grade Purity: Rigorously controlled manufacturing processes yield a product with a consistent assay of >99%, minimizing unknown impurities and simplifying your regulatory filings.
Proven Supply Chain: We guarantee a transparent, reliable supply chain that supports your needs from clinical trial materials to full-scale commercial production.
Partner with Your Trusted SAMe API Supplier
We understand the challenges of sourcing high-quality, stable SAMe.
Here’s how we solve them:
1. Unmatched Stability & Bioavailability
Problem: SAMe degrades quickly, leading to wasted inventory and compromised efficacy.
Our Solution:
Patented Stabilization Technology: Dual-layer encapsulation ensures a 24-month shelf life (vs. the industry standard of 12 months).
Third-Party Verified: Independent labs confirm >99% purity (COA available on request).
2. Compliance & Transparency
Problem: Regulatory risks from untraceable or non-compliant raw materials.
Our Solution:
Full Documentation: Batch-specific Certificates of Analysis (COA).
GMP & NSF Certified: Ideal for pharmacies needing USP compliance.
S-Adenosyl-L-Methionine Applications and Specifications
Manufacturer Documents Download
Key Applications for Your Business
Compounding Pharmacies
Mental Health: SAMe + 5-HTP or methylfolate for depression/anxiety protocols.
Joint Health: SAMe + glucosamine/chondroitin for osteoarthritis.
Custom Dosages: Tablet, capsule, or sublingual formulations.
Supplement Importers
White-Label Formulas: SAMe + B vitamins for liver support.
Ready-to-Package: Pre-blended SAMe with enteric coatings for retail brands.
Product Name: Bulk S-Adenosyl-L-Methionine Disulfate Tosylate (SAMe Disulfate Tosylate) (中文名:腺苷蛋氨酸对甲苯磺酸二硫酸盐)
Appearance: A white crystalline powder
Solubility: Soluble in water
Cas Number:97540-22-2 as salt (200393-05-1 as base)
Molecular Formula: C19H32N6O11S3
Molecular Weight: 616.7 g/mol
HS Code: 2938909090 (其他天然或合成再制的苷及其盐等)
Suitability for shipment by air/sea/rail as common goods: suitable. It is safe to be shipped by air as common goods.
Grade: Pharma Grade
Purity or Assay: 99.0% as min (By HPLC)
Standards: USP/EP
Manufacturer Documents Available: WC/COA/MSDS/SDS/HALAL/KOSHER
Supply Capability: Over 300 KG per month
MOQ: 1 KG
Lead Time: 3~4 days for quantities less than 100 KG
Stock Status: Over 100 KG
Shipping Temperature: Room temperature
Storage: Room temperature
FAQs About Our Bulk SAMe
1. What is Ademetionine Disulfate Tosylate, and how is it different from other SAMe salts?
Ademetionine Disulfate Tosylate is a specific salt form of S-Adenosylmethionine (SAMe). The key difference lies in its chemical stability. The disulfate-tosylate moiety is designed to better protect the labile sulfonium ion in the SAMe molecule, resulting in superior resistance to degradation compared to more common salts such as 1,4-butanedisulfonate. This makes it an excellent choice for formulations requiring a longer shelf life or those manufactured in challenging climates.
2. What are the primary therapeutic applications of Ademetionine Disulfate Tosylate?
This API is used in the manufacture of prescription and nutraceutical products for:
Liver Health: Treatment of intrahepatic cholestasis, alcoholic liver disease, and drug-induced liver injury.
Mental Wellness: Management of major depressive disorder and related mood conditions.
Joint Health: Alleviation of pain and inflammation associated with osteoarthritis.
3. What is your Minimum Order Quantity (MOQ)?
We offer flexible MOQs to cater to diverse client needs. Our standard MOQ for new clients is 1 kg for evaluation purposes. For compounding pharmacies, we can accommodate smaller initial orders. Competitive tiered pricing is available for larger commercial volumes.
4. Do you provide samples for our R&D and quality testing?
Yes, we provide free samples to qualified businesses, including pharmaceutical manufacturers and compounding pharmacies, for R&D, analytical method validation, and pilot-scale batch production. Each sample comes with a batch-specific Certificate of Analysis (COA).
5. Given its sensitivity, what are your specific storage and handling recommendations?
To preserve integrity, the API must be stored at -20°C or below in its original, tightly sealed container, protected from light and moisture. During handling, the product should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation. We recommend using low-humidity processing areas for formulation.
6. What pharmacopoeial standards do you comply with?
Our Ademetionine Disulfate Tosylate is manufactured to meet the specifications of the European Pharmacopoeia (Ph. Eur..) and the United States Pharmacopeia (USP). Our quality management system ensures batch-to-batch consistency in line with these standards.
7. What technical data and documentation can we expect?
You will receive a batch-specific Certificate of Analysis (COA) with every shipment. We also provide a full Safety Data Sheet (SDS), a detailed Technical Dossier, and available stability data (accelerated and long-term) to aid in your formulation development and shelf-life justification.
8. Is this API suitable for compounding pharmacies?
Absolutely. Our Ademetionine Disulfate Tosylate bulk powder is an ideal raw material for compounding pharmacies creating customized dosage forms, such as oral capsules or troches. Its enhanced stability is a significant advantage in a pharmacy setting where controlled storage conditions can be variable.
9. What documentation is provided for pharmacy compliance?
We supply all necessary documentation for pharmacy auditing and compliance, including a detailed Certificate of Analysis (COA) to verify purity and a comprehensive Safety Data Sheet (SDS) for safe handling.
10. Are your manufacturing facilities certified?
Our production is carried out in a GMP-certified facility that also holds ISO 9001:2015 certification for quality management. We welcome and regularly undergo customer and third-party audits.
11. What is your standard lead time?
For standard orders, our lead time is 3-5 days. We maintain strategic inventory for key products to accommodate urgent requests. For large-volume orders, we will provide a definitive production and shipping schedule upon order confirmation.
Other Supplements You May Like
