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Bacitracin Zinc Structure
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What is bacitracin zinc?
Cas number: 1405-89-6
Chemical Formula: C66H101N17O16SZn
Molecular Weight: 1486.067
Bacitracin Zinc is a complex of zinc and bacitracin. It is a white or off-white powder with its characteristic odor and bitter taste. It is a mixture of related cyclic peptides produced by organisms of the licheniformis group of Bacillus subtilis var Tracy. These peptides disrupt Gram-positive bacteria by interfering with the cell wall and peptidoglycan synthesis
It is one of our USFDA-Approved pharmaceutical ingredients along with bacitracin and polymyxin b sulfate. It is an effective narrow-spectrum antibiotic peptide with a similar antibacterial spectrum to penicillin, mainly for Gram-positive cocci and bacilli. Zinc bacitracin powder also exerts a certain inhibitory effect on several Gram-negative bacteria, spirochetes, and actinomycetes with attributes of high efficiency, low toxicity, and low residue.
First thing first, we must mention it upfront, there are two types of bacitracin zinc powder: 1. high-potency type Pharm-Grade (Potency No Less Than 65IU/MG); 2. Feed-Grade or Industrial-Grade (Potency Less than 40IU/MG). Here we mainly discuss pharm-grade zinc bacitracin.
How is bacitracin zinc produced?
1. Fermentation process using Bacillus subtilis and B. licheniformis to get bacitracin solution. (Bacitracin solution is an extraction and separation solution of a Bacillus subtilis and a B-type Bacillus licheniformis fermentation broth with a potency of no less than 5000 u/ml and a conductance of less than 2000 μs/cm).
2. An alkaline solution is added to the bacitracin solution to adjust the pH as 8 to 11, add inorganic zinc salt, adjust pH as 5 to 7 with an inorganic acid, stir for 1 to 2 hours, and let stand for 5 to 10 hours. (The alkaline solution can be either ammonia water or sodium hydroxide. The inorganic zinc salt is one of zinc oxide, zinc chloride, and zinc sulfate. The inorganic acid is one of hydrochloric acid and sulfuric acid.)
3. Bacitracin zinc is then obtained by separation, drying, pulverization, sieving, inspection.
The total content of bacitracin A should be greater than 40.0%, the total amount of bacitracin A, B” B2 and B3 should be greater than 70.0%, Potency should be no less than 65IU/MG.
Zinc Bacitracin obtained by this method could be used for medicinal preparations such as aerosol sprays and ointments.
What can bacitracin zinc be used for?
Bacitracin zinc can be used by combining with other topical antibiotics (usually Polymyxin B sulfate and Neomycin) as an ointment (well-known as Pfizer’s Neosporin). It is used for the topical treatment of a variety of localized skin infections, as well as for the prevention of wound infections.
It is also indicated for Empyema, Infection NOS, Pneumonia, Corticosteroid-responsive Dermatosis, Infection in minor cuts, scrapes, or burns, Inflammatory ocular disease, etc (Made into cortisporin ophthalmic ointment).
There is zinc bacitracin ointment used as first aid to help prevent infection in minor cuts, scrapes, burns.
There are people using formulations of bacitracin zinc for acne when acne pimples are infected. People would combine bacitracin zinc ointment with cleansers containing benzoyl peroxide to kill bacteria that might colonize an injured pimple.
However, zinc bacitracin doesn’t always cure acne. Some people report no improvement or even worse outbreaks after applying it.
There are bacitracin zinc ophthalmic solutions of non-ointment forms for eye infections. There are also Ophthalmic Ointments of Bacitracin Zinc and Polymyxin B Sulfate indicated for the treatment of superficial infections of the external eye and its adnexa caused by susceptible bacteria.
Bacitracin zinc dosage details are as below:
Bacitracin zinc Topical Ointment, Strength: 500IU/G [Each gram contains Bacitracin Zinc (equal to 500 bacitracin units)]
Bacitracin zinc Ophthalmic Ointment of 3.5 grams in tubes. Each gram contains bacitracin zinc equivalent to 500 bacitracin units, polymyxin B sulfate equivalent to 10,000 polymyxin B units, mineral oil, and white petrolatum.
10 Person First Aid Kit including: Bacitracin zinc (400 [iU]/1g) + Acetaminophen (325 mg/1) + Acetylsalicylic acid (325 mg/1) + Benzalkonium chloride (0.13 g/100g) + Benzalkonium chloride (0.40 mL/100mL) + Benzocaine (6 mL/100mL) + Ethanol (60 mL/100mL) + Ibuprofen (200 mg/1) + Lidocaine (0.5 1/100g) + Neomycin sulfate (5 mg/1g) + Polymyxin B sulfate (5000 [iu]/1g) + Water (98.6 mL/100mL)
Bacitracin Zinc Soluble Powder (Bacitracin Zinc Soluble Powder is a mixture of bacitracin zinc and zinc proteinates. It contains not less than 90.0 percent and not more than 120.0 percent of the labeled amount of having a bacitracin concentration that is nominally bacitracin.)
bacitracin zinc ointment for eczema
Bacitracin Zinc and Polymyxin B Sulfate Ointment
Polymyxin B Sulfate and Bacitracin Zinc Topical Aerosol
Polymyxin B Sulfate and Bacitracin Zinc Topical Powder
Bacitracin zinc vs bacitracin
bacitracin zinc is bacitracin with zinc (bacitracin zinc salt). Bacitracin zinc and bacitracin are produced in the same way but processed differently to get different products. Metal zinc within bacitracin zinc makes bacitracin more stable. BeLow we list the differences between bacitracin znc and bacitracin.
As we mentioned above, zinc salt makes the peptide bacitracin more stable when exposed to air and moisture. Though they have the same shelf life as three years when properly stored and sealed, it will be another case when the package is broken.
#2. Production capacity and polularity
Market demand for bacitracin zinc is much bigger than bacitracin. On one hand, bacitracin zinc is used in more ointments and aerosol sprays than bacitracin. Take the famous brands such as Neosporin and Polysporin for example, they both contain bacitracin zinc and polymyxin b sulfate, but neosporin contains the extra third ingredient neomycin sulfate. Only very small portion of the people who are allergic to neomycin sulfate would have to choose ointments containing bacitracin only. On the other hand, bacitracin zinc is also widely used poultry feed industry and the quantity is way bigger than the use in pharmaceutical industry.
Due to bigger production quantity, the cost of bacitracin zinc is brought to a lower level than bacitracin cost. You can also check bacitracin zinc price below with bacitracin price on our bacitracin page for your comparison. You can see pharm-grade Bacitracin zinc price is around 600usd/kg, bacitracin price is around 700usd/kg. Not to mention bacitracin zinc used for food and poultry industry, the price is even lower.
Bacitracin zinc vs zinc oxide
zinc oxide is also used in many products for skin as zinc bacitracin. Some people even can’t help asking, “Is bacitracin zinc the same as zinc oxide?” But what exactly is the main difference between zinc oxide and bacitracin zinc?
Excluding their chemical property differences, Zinc Oxide is an inorganic chemical, Bacitracinc zinc is an organic peptide, they have different cas no, molecular weight etc, zinc oxide is mainly used to treat skin conditions, including dermatitis, itching due to eczema, diaper rash and acne. Bacitracin zinc is mainly used as an antibiotic for infections of wounds. Below is detailed zinc oxide usage introductions and comparison.
Zinc oxide is contained in baby powder and barrier creams to treat diaper rashes, calamine cream, anti-dandruff shampoos, and antiseptic ointments. It is also a component in tape (zinc oxide tape) used by athletes as a bandage to prevent soft tissue damage during workouts.
Zinc oxide can be used in ointments, creams, and lotions to protect against sunburn and other damage to the skin caused by ultraviolet light. Zinc oxide blocks both UVA (320–400 nm) and UVB (280–320 nm) rays of ultraviolet light to prevent sunburn. It works as the broadest spectrum UVA and UVB absorber. Zinc oxide and the other most common physical sunscreen, titanium dioxide, are considered to be nonirritating, nonallergenic, and non-comedogenic. Whereas bacitracin zinc works by killing bacteria in the wounds to get a quick healing.
But the Zinc oxide cost is only 1/50 of bacitracin zinc price, if not even less.
Side Effects of bacitracin zinc includes but not limited to: skin burning, red skin, skin irritation, skin dryness, itching, stinging, scaling and sores.
Bacitracin Zinc is contraindicated in individuals who have shown hypersensitivity to any of its components (Bacitracin zinc is a mixture anyway).
What is bacitracin zinc price?
Zinc bacitracin cost of commercial order quantities is about 600usd/kg(60IU/MG).
Feed-grade bacitracin zinc powder price is about 300usd/kg. (40IU/MG)
15% bacitracin zinc premix price is about 3usd/kg, 2usd/kg for 10% type for commercial order quantities.
For more accurate prices, please contact us directly.
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