Best Bacitracin Zinc Powder In China
Looking For The Largest Bacitracin Zinc Manufacturer In China?
Contact Us Now!
Why You Should Choose Us As Your Bacitracin Zinc Supplier?
#1. High quality:
USP grade pure powder is registered and approved by USFDA and CEP, COPP and WC available. Our factory is a verified supplier for J&J, Pfizer, GSK, etc.
#2. Quality guarantee:
You will get 100% refund for any quality issues. Our customers had Zero quality issues over the past 7 years. For our regular customers, we are so sure about the quality that we are offering credits for our VIP customers.
#3. Free sample for testing available:
If you want to check its quality, contact us for a sample request. We will get it done!
What Is Bacitracin Zinc?
Cas number: 1405-89-6
Chemical Formula: C66H101N17O16SZn
Molecular Weight: 1486.067
HS Code: 2941909000
Bacitracin zinc is a complex of zinc and bacitracin. It is a white or off-white powder with its characteristic odor and bitter taste.
It is a mixture of related cyclic peptides produced by organisms of the licheniformis group of Bacillus subtilis var Tracy.
These peptides disrupt gram-positive bacteria by interfering with the cell wall and peptidoglycan synthesis.
It is an effective narrow-spectrum antibiotic peptide with a similar antibacterial spectrum to penicillin, mainly for Gram-positive cocci and bacilli.
Zinc bacitracin also exerts a certain inhibitory effect on several Gram-negative bacteria, spirochetes, and actinomycetes with attributes of high efficiency, low toxicity, and low residue.
First thing first, we must mention it upfront, there are two types of powders:
1. high-potency type Pharm-Grade (Potency No Less Than 65IU/MG);
2. Feed-Grade or Industrial-Grade (Potency Less than 40IU/MG).
Here we mainly supply pharm-grade type used to manufacturing medicines for humans.
How Is Bacitracin Zinc Powder Produced?
Fermentation process using Bacillus subtilis and B. licheniformis to get bacitracin solution.
(Bacitracin solution is an extraction and separation solution of a Bacillus subtilis and a B-type Bacillus licheniformis fermentation broth with a potency of no less than 5000 u/ml and a conductance of less than 2000 μs/cm).
#2. PH Adjustment
An alkaline solution is added to the bacitracin solution to adjust the pH as 8 to 11, add inorganic zinc salt, adjust pH between 5 to 7 with an inorganic acid, stir for 1 to 2 hours, and let stand for 5 to 10 hours.
(The alkaline solution can be either ammonia water or sodium hydroxide. The inorganic zinc salt is one of zinc oxide, zinc chloride, and zinc sulfate. The inorganic acid is one of hydrochloric acid and sulfuric acid.)
It is then obtained by separation, drying, pulverization, sieving, inspection.
The total content of bacitracin A should be greater than 40.0%, the total amount of bacitracin A, B” B2 and B3 should be greater than 70.0%, Potency should be no less than 65IU/MG.
What Is Bacitracin Zinc Powder Used For?
It can be used by combining with other topical antibiotics (usually Polymyxin B sulfate and Neomycin) as an ointment (well-known as Pfizer’s Neosporin).
It is used for the topical treatment of a variety of localized skin infections, as well as for the prevention of wound infections.
It is also indicated for Empyema, Infection NOS, Pneumonia, Corticosteroid-responsive Dermatosis, Infection in minor cuts, scrapes, or burns, Inflammatory ocular disease, etc (Made into cortisporin ophthalmic ointment).
Its ointments are used as first aid to prevent infections in minor cuts, scrapes or burns.
There are people using its formulations for acne when acne pimples are infected.
People would combine its ointment with cleansers containing benzoyl peroxide to kill bacteria that might colonize an injured pimple.
However, the method above does not always cure acne.
Some people reported no improvement or even worse outbreaks after applying it.
There are ophthalmic solutions of non-ointment forms for eye infections.
There are also Ophthalmic Ointments with Polymyxin B Sulfate indicated for the treatment of superficial infections of the external eye and its adnexa caused by susceptible bacteria.
All in all, zinc bacitracin is used in many dosages to prevent infections in small or shallow wounds.
You can find its common dosages as below:
What Are Bacitracin Zinc Dosages?
Its common dosage forms include:
Topical Ointment, Strength: 500IU/G [Each gram contains Bacitracin Zinc (equal to 500 bacitracin units)]
Ophthalmic Ointment of 3.5 grams in tubes. Each gram equivalent to 500 bacitracin units, polymyxin B sulfate equivalent to 10,000 polymyxin B units, mineral oil, and white petrolatum.
10 Person First Aid Kit including: Bacitracin zinc (400 [iU]/1g) + Acetaminophen (325 mg/1) + Acetylsalicylic acid (325 mg/1) + Benzalkonium chloride (0.13 g/100g) + Benzalkonium chloride (0.40 mL/100mL) + Benzocaine (6 mL/100mL) + Ethanol (60 mL/100mL) + Ibuprofen (200 mg/1) + Lidocaine (0.5 1/100g) + Neomycin sulfate (5 mg/1g) + Polymyxin B sulfate (5000 [iu]/1g) + Water (98.6 mL/100mL)
Soluble Powder (Bacitracin Zinc Soluble Powder is a mixture of bacitracin zinc and zinc proteinates. It contains not less than 90.0 percent and not more than 120.0 percent of the labeled amount of having a bacitracin concentration that is nominally bacitracin.)
Ointment for eczema
Ointment with Polymyxin B Sulfate
Topical Aerosol with Polymyxin B Sulfate
Topical Powder with Polymyxin B Sulfate
Bacitracin Zinc vs Bacitracin
Bacitracin zinc and bacitracin are produced in the same way but processed differently to get different products.
Zinc within bacitracin makes the complex even more stable.
BeLow we have listed the differences between the two.
As we mentioned above, zinc salt makes the peptide bacitracin more stable when exposed to air and moisture.
Though they have the same shelf life as three years when properly stored and sealed in our certificate of analysis, it will be another case when the package is broken.
Because bacitracin is very easy to absorb moisture and decompose, when the highest bacitracin concentration is reached in the fermentation process, we add zinc salt directly to culture solution to get a more stable zinc complex, namely zinc bacitracin.
Bacitracin zinc is widely used in the feeding industry because of its inherent characteristics and is currently the most used antibiotic feed additive.
Compared with bacitracin, the stability of bacitracin zinc is extremely superior: in a dry state, its potency can be kept at room temperature for 3 years without any change, even in acidic, alkaline or hot environments, its stability is also better.
According to reports, when bacitracin zinc is stored for 24 months at a temperature of 40°C, its potency is only lost by 10%; however, bacitracin in feces begins to decompose at room temperature in 3 to 6 days, and it decomposes in compost even faster
#2. Market demand and usages
Market demand for bacitracin zinc is much bigger than bacitracin.
On the one hand, bacitracin zinc is used in more ointments and aerosol sprays than bacitracin.
Take the famous brands such as Neosporin and Polysporin for example, they both contain bacitracin zinc and polymyxin b sulfate, but neosporin contains the extra third ingredient neomycin sulfate.
Only very small portion of the people who are allergic to neomycin sulfate would have to choose ointments containing bacitracin only.
On the other hand, bacitracin zinc is also widely used poultry feed industry and the quantity is way bigger than its use in pharmaceutical industry, not to mention the quantity of bacitracin.
Due to bigger production quantity, the cost of bacitracin zinc is brought to a lower level than the bacitracin cost.
You can also check it price below with bacitracin price on our bacitracin page for your comparison.
You can see that pharm-grade Bacitracin zinc price is around 600usd/kg, while bacitracin price is around 700usd/kg.
Not to mention bacitracin zinc used for food and poultry industry, the price is even lower.
Bacitracin Zinc vs Zinc Oxide
Zinc oxide is also used in many products for skin as zinc bacitracin. Some people even can’t help asking: Is bacitracin zinc the same as zinc oxide?
But what exactly is the main difference between those two?
Excluding their chemical property differences, Zinc Oxide is an inorganic chemical, Bacitracinc zinc is an organic peptide.
They have different cas no, molecular weight etc.
Zinc oxide is mainly used to treat skin conditions, including dermatitis, itching due to eczema, diaper rash and acne.
Bacitracin zinc is mainly used as an antibiotic for infections of wounds.
Below is the detailed zinc oxide usage introductions and comparison.
Zinc oxide is contained in baby powder and barrier creams to treat diaper rashes, calamine cream, anti-dandruff shampoos, and antiseptic ointments.
It is also a component in tape (zinc oxide tape) used by athletes as a bandage to prevent soft tissue damage during workouts.
Zinc oxide can be used in ointments, creams, and lotions to protect against sunburn and other damage to the skin caused by ultraviolet light.
Zinc oxide blocks both UVA (320–400 nm) and UVB (280–320 nm) rays of ultraviolet light to prevent sunburn.
It works as the broadest spectrum UVA and UVB absorber.
Zinc oxide and the other most common physical sunscreen, titanium dioxide, are considered to be nonirritating, nonallergenic, and non-comedogenic.
Whereas bacitracin zinc works by killing bacteria in the wounds to get a quick healing.
But the Zinc oxide cost is only 1/50 of bacitracin zinc price, if not even less.
What Are Bacitracin Zinc Side Effects?
Its side Effects includes but not limited to:
skin burning, red skin, skin irritation, skin dryness, itching, stinging, scaling and sores.
It is contraindicated in individuals who have shown hypersensitivity to any of its components (Bacitracin zinc is a mixture anyway).
How Much Does Bacitracin Zinc Powder Cost? (2021 Updated)
The price for commercial order quantities over 100kg is about 600usd/kg(60IU/MG).
For the cost in tons, the price is around 550usd per kg.
In year 2021 the price of pharm-grade zinc bacitracin has dropped to 530usd per kilo due to increasing demand and larger production capacity.
Feed-grade powder price is about 300usd/kg. (40IU/MG)
15% premix price is about 3usd/kg, 2usd/kg for 10% type for commercial order quantities.
For more accurate prices, please contact us directly.
Please check the export prices from pharmacompass for your ref below:
As you can see the import and export prices from pharmacompass, the highest unit price is 1005 usd/kg for 2kg imported from Nepal from India, which is plausible when you add in all the shipping costs by air.
You can also see the main-stream prices by 534 usd/kg with import quantity of over 8 tons.
Our Indian friends always negotiate a better offer with their huge buying quantities.
Also we composed a price trends since 2012 to now for your reference as below.
What Are Bacitracin Zinc Powder Price Trends?
The price trends above show a drop on the cost.
It makes sense when the demand quantities have increased and the cost is getting down little by little.
From the highest over 800usd per kg to currently 550usd per kg.
Please note, this price is only suitable for commercial order quantities over hundreds of kilos.
If you only buy hundreds of grams, unit price will be higher.
You can contact us anytime for its lastest price.
How To Ship and Store Bacitracin Zinc Powder?
First, it is one the safest chemicals to be shipped by air. It is not dangerous, not flammable, not explosive in anyway.
We have certificate of safe air transportation issued by DGM, SRICI, etc.
Though bacitracin is an antibiotic, stability study has found that dry pure bacitracin powder is even stable at temperatures as high as 37 degree celsius, but decomposes at 56° and 80°.
Aqueous solutions, adjusted to pH 5 to 7 with or without buffers, are stable for several months at refrigerator temperature, but lose activity rapidly at room temperature.
Zinc bacitracin is even more stable than bacitracin.
That’s why we can can ship it under room temperature.
Just make sure the temperature is not too high.
Also seal it well to protect it from moisture and light during the transportation.
When it has reached your warehouse, store it in a cool, dry and temperature stable evironment.
Room temperature for its storage is fine, no need to be stored at 2~8° as other antibiotics.
Technical Documents Download
- Bacitracin In wikipedia
- Bacitracin Zinc Topical from Drugs.com
- Triple antibiotic ointment in Wikipedia
- Stability of bacitracin from sciencedirect
- BACITRACIN ZINC AND POLYMYXIN B SULFATE ointment from Dailymed
- Zinc Oxide from Wikipedia
- Bacitracin Zinc Purification Patent