99% Spironolactone API Powder With The Best Prices
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Why You Should Import Spironolactone Powder From Us?
#1. High Quality:
GMP&CEP&FDA Approved with Standards of USP/EP/CP
#2. Samples Available For Quality Approval:
Though the product itself is not very cheap, we can still arrange samples for your testing.
#3. Low MOQ:
Though our standard packing is 25kg/Drum from the GMP factory, we have smaller packings of 1kg/tin for your trial order too.
#4. Quality guarantee:
There will be a full refund to you if there are any quality issues.
What Is Spironolactone?
Cas No.: 52-01-7
Molecular Formula: C24H32O4S
Molecular Weight: 416.62
Chemical Name: S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5′-dioxospiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,2′-oxolane]-7-yl] ethanethioate
HS Code: 2932999099（Other heterocyclic compounds containing only oxygen heteroatoms-其他仅含氧杂原子的杂环化合物）
Spironolactone is one of our GMP-Approved Pharmaceutical Ingredients along with Amphotericin B, Bacitracin, Cyclosporine, etc.
It is a white to off-white powder, a potassium-sparing diuretic that competitively inhibits mineralocorticoid receptors in the distal convoluted tubule to promote sodium and water excretion and potassium retention.
It is an aldosterone receptor antagonist and potassium-sparing diuretic widely used in the therapy of edema, particularly in patients with cirrhosis in which hyperaldosteronism appears to play a major role. It has been linked to rare cases of clinically apparent drug induced liver disease.
Doctors would prescribe it to treat several conditions including heart failure, deem, hyperaldosteronism, adrenal hyperplasia, hypertension, and nephrotic syndrome.
Its off-label uses include hirsutism(extra facial hair), female pattern hair loss, and adult acne vulgaris.
What Are Spironolactone Dosages?
Tablets (25 mg, 50 mg, and 100 mg)
Oral Suspension (2mg/ml, 25/5ml)
Compound Oral Suspension (5mg/ml)
Veterinary Compounded Oral Suspension
Compound Oral Suspension with Hydrochlorothiazide
Compound Tablets with Hydrochlorothiazide
Spironolactone vs Eflornithine
As we all know, both spironolactone and eflornithine hydrochloride can be used for female facial hirsutism, but what are their differences?
#1. Dosage forms
Spironolactone is made into tablets or oral suspensions but never used topically.
While eflornithine is mainly made into topical creams well-known as Vaniqa of Gillette.
There was an eflornithine injection, but it was discontinued for safety reasons.
#2. Working Mechanism
Spironolactone is also used for facial hirsutism due to its androgen-blocking ability.
It works by blocking androgen’s ability to affect the human body.
It is similar to finasteride in the androgen blocking mechanism.
But it may take 3 to 6 months for spironolactone to work.
Many will use birth control pills together with spironolactone for a better facial-hair-ridding effect because birth control pills can reduce androgen production.
Eflornithine hydrochloride is also used to treat hirsutism, but it works by interfering with a chemical in hair follicles under the skin to slow hair growth when applied topically.
Please note, that eflornithine topical does not permanently remove facial hair or prevent hair growth.
#3. Social influence
The topical eflornithine cream has long been indicated for the treatment of facial hirsutism in women.
Eflornithine cream is the main-stream cure for hirsutism, while spironolactone is only auxiliary.
In clinical studies with Vaniqa, 81% percent of women showed clinical improvement after twelve months of treatment.
Positive results were seen after eight weeks.
However, discontinuation of the cream caused regrowth of hair back to baseline levels within 8 weeks.
But eflornithine topical cream does significantly reduce the psychological burden of facial hair.
#4. Price
Due to the small demand for eflornithine hydrochloride in the market, eflornithine did not get commercially produced in China and its price has been very high.
While spironolactone has been commercially produced long ago, the cost of spironolactone is only 1/10 of eflornithine.
What Are Spironolactone Side effects?
Side effects include but are not limited to the following:
1. Vomiting, diarrhea, and stomach pain or cramps
2. Dry mouth and thirst
3. Dizziness, mild drowsiness, or headache
4. Swelling breast
5. Irregular menstrual periods and post-menopausal vaginal bleeding
6. Impotence
7. Deepening of the voice and increased hair growth
8. Drowsiness, tiredness, and restlessness
9. Muscle pain or weakness
10. Numbness or tingling
11. Paralysis in the arms or legs
12. Arrhythmia
13. Confusion, extreme tiredness, and fainting
14. Unusual bleeding or bruising
15. Life-threatening skin reactions
16. Flu-like symptoms, pain in the upper right abdomen, loss of appetite, vomiting blood, or bloody stools
17. Difficulty breathing or swallowing
What Are Spironolactone Interactions?
The metabolism of Warfarin could be decreased when combined with it.
The therapeutic efficacy of 4-Methoxyamphetamine, 4-Bromo-2,5-dimethoxyphenethylamine, Abediterol and Abiraterone could be decreased when used in combination with it.
It may increase the excretion rate of Acarbose which could result in a lower serum level and potentially a reduction in efficacy.
The risk or severity of hyperkalemia can be increased when it is combined with Acebutolol.
It has negative interactions with but is not limited to the following active pharmaceutical ingredients:
Lithium; ACE inhibitors such as benazepril;
Angiotensin II receptor blockers such as azilsartan; Digoxin; Cholestyramine;
Steroids such as progesterone, prednisone, medroxyprogesterone;
non-steroidal anti-inflammatory ingredients such as Ibuprofin, paracetamol, aspirin;
Aldosterone receptor antagonists such as Eplerenone; Heparin sodium;
Skeletal muscle relaxers such as cyclobenzaprine, Rocuronium Bromide, Vecuronium bromide, Pancuronium bromide;
Diuretics, such as amiloride; Norepinephrine;
Potassium supplements
Alcohol can increase the chance of certain side effects so alcohol should be avoided while taking it.
How Much Does Spironolactone Powder Cost?
The cost of the pure powder depends on your order quantity.
If you only order 1kg, our door-to-door price by courier is around 450~550usd.
Our cost for commercial order quantities such as 100kg~1000kg is around 300usd/kg~350usd/kg.
Leave us a message to get the latest price!
We also have samples packed in smaller packages suitable for research and compounding pharmacies.
Let’s say you need 100 grams of pharmaceutical grade powder for research, how much you will pay if you buy it online from reagent companies?
Check the prices online and you will find.
Unit price from sigma is 237USD for 5 Gram
Cost from scbt is 100USD for 50 MG
Price from tocris is 64USD for 50 MG
If you are buying spironolactone in commercial quantities, you can check its import and export price from India for your ref below.
As you can see from the above export price from India, the average price is 400USD per kilo in 2016, the export price from China to India by Tons was 301USD per kilo.
If you are having offers lower than 300USD, pay special attention, as you know our Indian friends drive a hard bargain.
Technical Documents Download
References
- https://www.drugs.com/spironolactone.html
- https://en.wikipedia.org/wiki/Spironolactone
- https://www.drugbank.ca/drugs/DB00421
- https://www.everydayhealth.com/drugs/aldactone
- https://www.drugs.com/mtm/eflornithine-topical.html
