99% Triamcinolone Acetonide API Of GMP Factory
Why Choose Us As Your Triamcinolone Acetonide Supplier
#1. FAST DELIVERY:
We are the supplier that has able freight agents to take care of the delivery for you safely.
Wherever you are located, we will make sure you can get it.
#2. Flexible packing options:
we can repack our pure powder of standard 1kilo package into smaller packing units such as 500g/bag, 100g/bag, etc, so we can make fast shipments for our small-business owners.
#3. Consistent Quality:
Due to our years of manufacturing experience, we manage to get a high yield for each production batch and our strict QC makes sure all goods are meeting quality requirements before they are released for export.
What Is Triamcinolone Acetonide?
Cas Number: 76-25-5
Molecular Formula: C24H31FO6
Molecular weight: 434.5g/mol
Chemical Name: (1S,2S,4R,8S,9S,11S,12R,13S)-12-fluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one
HS Code: 2937229000 (Other halogenated derivatives of adrenal cortex hormones-其他肾上腺皮质激素的卤化衍生物))
Triamcinolone acetonide is a white to off-white powder widely used for skin conditions.
It is practically insoluble in water and sparingly soluble in ethanol and methanol.
It is not soluble in acetone but slightly soluble in chloroform.
It is one of the medium-acting synthesized glucocorticoids you see often in many ointments for skin infections.
As one of the more potent triamcinolone derivatives, it is about 6~8 times as potent as prednisone, and 5 times as hydrocortisone.
What Is Triamcinolone Acetonide Used For ?
Triamcinolone acetonide is an adrenal cortex hormone pharmaceutical ingredient, which acts on glucose metabolism and can reduce the pathological response of antibody tissues to damaging stimuli.
It is used for active rheumatism and rheumatoid arthritis.
Triamcinolone acetonide is an intermediate-acting glucocorticoid, which has anti-inflammatory, anti-itching, and vasoconstriction effects.
The water and sodium retention effect is weak, and the anti-inflammatory effect is strong and lasting.
For dermatitis and other skin diseases, it can be absorbed by the skin topically.
It can be used but is not limited to the conditions below:
1. Dermatitis and eczema accompanied by fungal infection or tendency to fungal infection;
2. Inflammatory dermatophytes caused by dermatophytes, yeasts, and molds:
Such as tinea hands and feet, tinea corporis, tinea cruris, and tinea versicolor;
3. Diaper dermatitis;
4. Paronychia and other diseases.
Due to the large scope of application of triamcinolone acetonide and econazole cream, the usage and dosage for the treatment of different diseases are different:
when treating dermatitis and eczema, the course of treatment is 2-4 weeks.
The treatment of inflammatory fungal diseases should continue until the inflammatory reaction subsides, and the course of treatment is not More than 4 weeks.
Use on thin skin areas such as face, underarms, groin, and vulva for no more than 2 weeks.
If symptoms do not relieve, please consult your doctor.
In addition, people with skin tuberculosis, syphilis, herpes, or varicella virus infection should not use triamcinolone acetonide.
During medication, avoid contact with eyes and other mucous membranes.
If there is burning, redness, and swelling at the medication site, stop the medication immediately, try to wash the site with clean water, and go to a hospital right after.
How Is Triamcinolone Acetonide Classified?
According to the biologically acting period, we divide glucocorticoids into 3 categories: short-acting, medium-acting, and long-acting hormones.
Short-acting hormones are also called natural hormones, which are synthesized and secreted by our adrenal glands, while medium- and long-acting hormones are synthesized artificially.
1. Short-acting glucocorticoids:
Features: Those are natural-existing hormones with weak anti-inflammatory effects, short-action periods, and less harm to the HPA axis.
They are not suitable for the treatment of chronic autoimmune diseases and we mainly use them for the replacement therapy of adrenal insufficiency.
2. Medium-acting glucocorticoids:
prednisone, prednisolone, methylprednisolone, triamcinolone acetonide.
The anti-inflammatory effect and half-life of those steroids are in the middle, between short-acting and long-acting.
So the side effects are less than the long-term Glucocorticoids.
Those are the most widely used glucocorticoids in clinical practice.
It is mainly used for the treatment of rheumatism, autoimmune diseases, and immune transplantation.
3. Long-acting glucocorticoids:
dexamethasone, betamethasone, and other methasone.
Features: they have strong anti-inflammatory effects, with a long-acting period, anti-allergic and healing effects.
However, they will significantly inhibit the HPA axis.
They are not recommended for long-term use but only should be used as a temporary med.
#1. Conversion of equivalent dose
Cortisone 25 mg = hydrocortisone 20 mg = prednisone 5 mg = prednisolone 5 mg = methylprednisolone 4 mg = triamcinolone acetonide 4 mg = betamethasone 0.75 mg = dexamethasone 0.75 mg
#2. Comparison of tissue penetration ability
The ability to penetrate the blood-brain barriers in order: methylprednisolone>dexamethasone>hydrocortisone
The ability to penetrate the placental barrier in order: dexamethasone>methylprednisolone>prednisone
Common Triamcinolone Acetonide Dosage Forms
Triamcinolone can be compounded into many formulations, we list the dosage forms from USP and EP for your ref.
Compounded cream with Neomycin Sulfate
Compounded cream or ointment with Nystatin, Neomycin Sulfate, Gramicidin
Compounded cream or ointment with Nystatin, Neomycin Sulfate, Thiostrepton
Compounded cream or ointment with Nystatin
Besides its formulations enlisted in USP and EP, there is also its compound cream with econazole nitrate, and compound ointment with Zinc Undecylenate in China.
How Much Does Triamcinolone Acetonide API Cost?
Before we indicate prices for its pure powders, we need to list its common forms in the market you can find:
#1. RS or WS substance or reagent grade substances sold by MG.
For those powders of RS or WS(Reference Substance or Working Standards), it is the most expensive type.
Its cost is around 100~200usd per MG.
#2. Bulk powder with Chinese GMP and DMF
This type of pure powder is approved by China FDA or MOH from other countries, and they are suitable for producing human medicines.
But the MOQ from GMP factories is one standard packing such as 5kilo/10kilo/25kilo.
Normally the unit price from the GMP factory is around 6000~8000USD/kilo.
#3. Bulk powder from the non-GMP factory.
There are plenty of non-GMP manufacturers of triamcinolone in China, the prices are slightly lower than GMP types.
Common prices for this type are around 3000~4000 USD/kilo.
No matter which type you are looking for, just make sure you are buying what you have paid for.
How To Ship And Store Triamcinoloe Acetonide Powder
Speaking of shipment for pure powder, it is a safe chemical to be shipped by air/courier, not to mention shipping by sea or by rail.
It has been tested by DGM and other institutions as a common chemical, not poisonous, not flammable or explosive, and not dangerous for shipping by air with normal packing.
If one chemical is safe for shipping without special packing required, it is safe to be shipped by sea or by rail, or trucks.
As for the storage, the stability data has shown that Triamcinolone acetonide powder is stable for 24 months during the tests.
Thus, you can store it at room temperature, just protect it from heat, moisture, and direct sunlight.
Manufacturer Documents Download
- http://endo.dxy.cn/article/606049 (丁香园)