Source 99% Hydroxypropyl Beta Cyclodextrin
Hydroxypropyl Beta Cyclodextrin—also known as HP-β-CD, Hydroxypropyl Betadex, and 2-Hydroxypropyl-β-cyclodextrin—is the active excipient behind countless innovative drug delivery, nutraceutical, and cosmetic formulations worldwide. As a hydrophilic derivative of β-cyclodextrin created through etherification with 1,2-propylene oxide, HP-β-CD has emerged as one of the most scientifically validated and commercially significant excipients in the global pharmaceutical industry.
We don’t just supply Hydroxypropyl Beta Cyclodextrin. We deliver pharmaceutical-grade purity, documented regulatory compliance, supply chain reliability, and technical partnership that give you a competitive edge in formulation development and commercial production—whether you’re manufacturing injectables, oral solids, topical formulations, or novel drug delivery systems.
Why Import HPBCD From Us?
#1. High-quality standards with a steady manufacturing procedure:
We produce our hpbcd powder in c-GMP-compliant manufacturing facilities; a steady, stable manufacturing process ensures our high quality. Both pharm-grade(Injection/oral) and food-grade are in stock for fast shipment.
#2. Quality guarantee:
If you have any quality issues after testing our 2-hydroxypropyl-β-cyclodextrin according to the USP or EP monographs, we will offer a full refund or a free exchange, plus a discount on your next order.
#3. Smaller packages of 100g, 200g, and 500g are available for testing and trial orders:
For new customers trying ourhydroxypropyl-betadexx for the first time, we have your back. We can repack the samples within 1 day and send them to you.
What Is Hydroxypropyl Beta Cyclodextrin(HPBCD)?
Technical Documents Download
Cas number: 128446-35-5
Molecular weight: 1541.5 g/mol
Molecular formula: C63H112O42
HS Code: 3505100000
Other names: 2-hydroxypropyl-β-cyclodextrin, hydroxypropyl betadex, 2-hydroxypropyl-beta-cyclodextrin, hpcd, hpbcd, hpβcd, hp-beta-cd, 2-hydroxypropyl-beta-cyclodextrin ether, hydroxypropylbetadex.
Hydroxypropyl β-cyclodextrin is a white to off-white amorphous crystalline powder.
It is freely soluble in water and propylene glycol.
Its solubility in water exceeds 100g per 100 mL at 25 degrees Celsius.
It is one of the most popular pharmaceutical excipients, Betadex Sulfobutil Éter Sódico.
It has overcome the poor solubility shortcomings of beta-cyclodextrin.
It enhances the solubility and stability of many APIs that are unstable and insoluble in water.
The compound-complex can penetrate our body tissues, allowing us to use it biologically to release active compounds under our desired conditions.
What Is Hydroxypropyl-Beta-Cyclodextrin Used For?
The introduction of the hydroxypropyl group breaks the intramolecular cyclic hydrogen bond of β-cyclodextrin.
It overcomes the main disadvantage of β-cyclodextrin’s poor water solubility while retaining the cyclodextrin cavity.
It is one of the most extensively studied and widely used cyclodextrin derivatives.
We will individually break down its usage in the food, cosmetics, and pharmaceutical industries.
1 In the food and spice industry
It can improve the stability and long-term effectiveness of nutritional molecules.
It will cover the bad smell and taste of nutritional ingredients.
It dramatically improves food production efficiency and quality.
HPBCD is well solubilized in water; when its degree of substitution exceeds 4, it can be dissolved in any proportion.
You can easily dissolve it in 50% ethanol and methanol.
2 In the cosmetic industry
It is widely used as a stabilizer, emulsifier, and deodorant.
It will help reduce the stimulation of organic molecules in cosmetics on the skin and mucous membranes.
It will also enhance the stability of active ingredients by preventing the volatilization and oxidation of nutrients.
Cyclodextrins can bind fragrances, releasing them when your skin heats them.
We can also eliminate the odor by trapping them, so those ingredients will not smell foul.
Don’t forget that hydroxypropyl beta-cyclodextrin is also hygroscopic.
When we add them to cosmetics and apply them to our skin, they draw moisture from our skin.
3. Usages in the pharmaceutical industry
3.1 Increase the water solubility of APIs in waterHydroxypropyl-β-cyclodextrinn is readily soluble in water.
Even better, it will improve drug solubility without adding organic solvents, surfactants, or lipids.
Being enveloped by them can significantly increase the water solubility of poorly soluble drugs.
After the drug forms a more complex structure with HP-β-CD, the drug concentration increases linearly with HP-β-CD concentration.
Lab Data:
After complexation of baicalin with hydroxypropyl β-cyclodextrin, we increased its solubility in water from 0.112 mg/ml to 2.743 mg/ml, a 24.5-fold increase.
3.2 Improve our drug stability and bioavailability
We should protect our drugs from light, heat, and humidity during storage.
Those factors will directly affect the stability and quality status of our drugs.
Therefore, medical stability is essential.
After HP-β-CD is introduced into our medicine, the active ingredients will enter the cyclodextrin cavity.
The cavity will prevent APIs from volatilizing, subliming, oxidizing, or photolyzing.
The HP-β-CD-encapsulated drug exhibits faster dissolution and release rates, thereby increasing its absorption in the body.
It will improve the bioavailability of the drug encapsulated.
Exemplos:
After estradiol is encapsulated in hydroxypropyl β-cyclodextrin and stored at room temperature, its degradation half-life increases from 1.2 years to 4 years.
After ursodeoxycholic acid is encapsulated with hydroxypropyl beta-cyclodextrin, its dissolution is faster and more complete with the same disintegration time.
Its oral bioavailability and peak concentration are more than twice those of similar commercially available ursodeoxycholic acid formulations without hydroxypropyl beta-cyclodextrin.
3.3 Reduce the toxicity and side effects of drugs
Complexing with insoluble drugs and changing the way we take the medicine can significantly reduce the toxicity and irritation of certain drugs to our bodies.
Because hydroxypropyl beta-cyclodextrin has a lower relative surface area and hemolytic activity and is not muscle-irritating, it is an ideal solubilizer and pharmaceutical excipient for injections.
It can enhance the water solubility of poorly soluble drugs, improve their stability, and increase their bioavailability.
It can also improve the drug efficacy with reduced dosing.
We can use it to adjust or control the drug-release rate and reduce the side effects, too.
Exemplos:
Nimodipine is difficult to dissolve in water, so we can’t make injections with it, and then patients have to take it orally.
However, when we take nimodipine oral tablets, they are first absorbed by the liver before entering the bloodstream.
Hydroxypropyl-beta-cyclodextrin can increase the solubility of nimodipine in water by 60-fold, allowing us to make injections instead.
Meanwhile, hydroxypropyl-beta-cyclodextrin will reduce the irritation to our muscles.
Hydroxypropyl β-cyclodextrin can also relieve injection pain associated with etomidate.
It plays the same role in many applications, such as voriconazole or itraconazole injections, mucosal delivery systems (nasal mucosa, rectum, cornea, etc.), transdermal absorption systems, carriers for lipophilic targeted drugs, and protective agents and stabilizers for proteins.