99% Bulk S-Acetyl-L-Glutathione Powder Of ISO Factory
S-Acetyl-L-Glutathione (SAG) is a stabilized and highly bioavailable derivative of the master antioxidant, glutathione (GSH).
Designed to overcome the significant absorption challenges of oral glutathione, our SAG raw material provides pharmaceutical manufacturers and compounding pharmacies with a reliable and efficacious ingredient for advanced therapeutic formulations.
At the molecular level, acetylation of the cysteine thiol group of glutathione protects it from degradation in the digestive tract and bloodstream, allowing it to reach cells intact. Once intracellular, cytoplasmic thioesterases cleave the acetyl group, releasing active, reduced glutathione directly where it is needed.
This mechanism is critical for replenishing intracellular GSH levels, which are often depleted by chronic conditions, oxidative stress, aging, and certain medications.
Why Import Bulk S-Acetyl-L-Glutathione From Us?
#1. High-Quality Guaranteed With ISO
Our bulk S-Acetyl-L-Glutathione powder is over 98% pure, as confirmed by HPLC and ISO certificates, with testing spectra.
Meanwhile, our quality remains consistently high from batch to batch, thanks to our optimized manufacturing process and standard operating procedures.
#2. Competitive prices with quick dispatch
With our extensive manufacturing capacity, we can lower production costs relative to our competitors and more easily differentiate our pricing.
Plus, we can prepare the goods for shipment within 2~3 days for quantities ranging from 100 g to 200 kg.
S-Acetyl-L-Glutathione Applications and Specifications
Manufacturer Documents Download
COA
MSDS
MOA
Our bulk S-Acetyl-L-Glutathione is the ideal raw material for formulators requiring a proven, bioavailable glutathione source.
Pharmaceutical Actives: For inclusion in prescription or OTC formulations targeting conditions related to oxidative stress, liver support, metabolic detoxification, and neuroprotection.
Compounding Pharmacy Formulas: Used by compounding pharmacists to create personalized dosage forms—including capsules, sublingual troches, transdermal gels, and intravenous preparations—for patients whose needs are not met by commercial products.
Clinical Nutraceuticals: For high-end dietary supplement brands developing evidence-based products focused on anti-aging, immune support, mitochondrial health, and detoxification pathways.
Cosmeceutical Applications: As a potent active ingredient in advanced skincare formulations for whitening, anti-aging, and antioxidant protection.
Product Name: Bulk S-Acetyl-L-Glutathione (S-乙酰-L-谷胱甘肽)
Appearance: A white to off-white powder
Cas Number: 3054-47-5
Molecular Formula: C12H19N3O7S
Molecular Weight: 349.36 g/mol
HS Code: 2930909099 (其他有机硫化合物)
Suitability for shipment by air as common goods: suitable. It is safe to be shipped by air as common goods.
Grade: Food-Grade
Purity or Assay: 98%
Standards: Current Enterprise Standards
Manufacturer Certificates available: ISO
Supplier Documents Available: COA/MSDS
Supply Capability: 300KG per month
MOQ: 100 G
Update S-Acetyl-L-Glutathione Raw Material Price Ideas: (Contact us by WhatsApp for more updated prices)
Lead Time: 3~6 days for quantities less than 50 KG, 3~4 days for orders less than 1000 g.
Stock Status: Over 200KG
Shipping Temperature: Room temperature
Storage: 2~8 °C Room temperature
FAQs About Our S-Acetyl-L-Glutathione in Bulk
Q1: What is the key advantage of S-Acetyl-L-Glutathione over regular Reduced Glutathione (GSH) for oral formulations?
The primary advantage is dramatically superior oral bioavailability. Reduced glutathione is hydrolyzed mainly in the gut by gamma-glutamyl transpeptidase, breaking it into its constituent amino acids before absorption. Studies have shown no significant increase in blood glutathione levels even with high oral doses of GSH. The acetyl group in SAG protects the molecule during digestion, allowing it to enter the bloodstream and cells intact, where it is then converted to active glutathione.
Q2: What crystalline form do you supply, and why does it matter for my formulation?
We supply the crystalline Form A of S-Acetyl-L-Glutathione. Different polymorphic forms (like Form A and Form B) have distinct physicochemical properties, including solubility, dissolution rate, and physical stability. These factors directly influence the consistency, manufacturability, and potentially the bioavailability of your final product. Using a characterized, stable polymorph (Form A) ensures batch-to-batch consistency and reliable performance in your formulation process.
Q3: Can you provide documentation for regulatory compliance?
Yes. We operate a cGMP-compliant manufacturing facility. For qualified buyers, we provide:
Batch-specific Certificate of Analysis (CoA) with complete HPLC purity data, residual solvent analysis, and heavy metal limits.
Material Safety Data Sheet (MSDS).
Traceability documentation from raw materials to the finished batch.
Q4: What is your standard lead time for bulk orders, and what packaging options are available?
For standard grades (≥98%), we can typically ship within 3-5 business days for orders up to 100kg. We offer flexible, secure packaging:
Standard: 1 kg in a double plastic bag inside an aluminum foil bag.
Bulk: 5 kg to 25 kg in sealed plastic drums or carton boxes.
Custom: For high-purity grades (≥99.5%), we offer packaging under an inert gas (argon or nitrogen) upon request to maximize shelf life.
Q5: Do you provide samples for quality evaluation and testing?
We provide evaluation samples to qualified businesses (pharmaceutical manufacturers, compounding pharmacies, and established supplement brands). A nominal fee may apply, which is often credited against a future bulk order.
Q6: What are the specific storage and stability requirements to maintain potency in our pharmacy or facility?
S-Acetyl-L-Glutathione requires strict storage conditions to maintain stability:
Temperature: Refrigerate at 2-8°C.
Environment: Keep the container tightly sealed, in a dry place, and protected from light.
Handling: Once opened, minimize exposure to air and moisture. Under these conditions, the product maintains its specified purity for 24 months.
Q7: What is the minimum order quantity (MOQ), and do you offer tiered pricing?
Our standard MOQ is 1 kilogram. We offer competitive tiered pricing that scales with order volume. Please get in touch with our sales team with your projected annual requirements for a formal quotation.
Q8: How does S-Acetyl-L-Glutathione function in the body after absorption?
After oral absorption, SAG circulates in the bloodstream and is taken up by cells. Inside the cell (in the cytoplasm), enzymes called thioesterases hydrolyze the acetyl bond. This releases the free, reduced (active) glutathione molecule, directly elevating the intracellular GSH pool where it is needed for antioxidant defense, detoxification (Phase II conjugation), and immune function.
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