99% Kojic Acid Dipalmitate Supplier In China
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Why You Should Import Kojic Acid Dipalmitate From Us?
#1. High Purity:
Our pure powder is 98% as minimum suitable for direct mixing for cosmetics, with no need for further refining.
#2. Stable supply:
We have running stocks of 100kg or more to keep our stock always fresh.
#3. Samples for quality approval are available:
We have spare samples packed ready for your testing anytime.
#4. Low MOQ:
though our standard packing is 25kg/drum, our MOQ starts from 1kg.
What Is Kojic Acid Dipalmitate?
Cas number: 79725-98-7
Molecular formula: C38H66O6
Molecular weight: 618.93
Chemical Name: (5-hexadecanoyloxy-4-oxopyran-2-yl) hexadecanoate
HS Code: 2932999099（Other heterocyclic compounds containing only oxygen heteroatoms-其他仅含氧杂原子的杂环化合物）
Kojic acid palmitate is the palmitate ester of Kojic acid.
It is an off-white powder with excellent anti-oxidant ability, also one of our most hot-selling cosmetic ingredients.
It is regarded as one of the most popular and effective skin-whitening agents in the cosmetic industry.
Studies have found that after coupling kojic acid palmitate with glucosamine derivatives, its whitening effect will increase exponentially.
What Is Kojic acid dipalmitate Used For?
Kojic acid dipalmitate is a compound that is often used in skincare products for its ability to lighten the skin and improve its overall appearance.
This compound is derived from kojic acid, which is a natural substance that is found in certain types of fungi.
When used in skincare products, kojic acid dipalmitate is typically used to lighten dark spots, freckles, and other areas of hyperpigmentation on the skin.
One of the primary benefits of using kojic acid dipalmitate in skin care products is that it is highly effective at lightening the skin.
This is because kojic acid dipalmitate can inhibit the production of melanin in the skin, which is the pigment that gives our skin its color.
By inhibiting the production of melanin, kojic acid dipalmitate can lighten the skin and improve its overall appearance.
In addition to its skin-lightening properties, kojic acid dipalmitate is also known for its ability to improve the overall texture and tone of the skin.
When applied topically, kojic acid dipalmitate can help to smooth out rough and uneven patches of skin, making it an effective treatment for conditions such as acne scars and other forms of scarring.
It can also help to improve the elasticity of the skin, making it look more youthful and radiant.
Kojic acid dipalmitate is also a powerful antioxidant, which means that it can protect the skin from damage caused by free radicals.
Free radicals are unstable molecules that can cause damage to the cells in our bodies, leading to a variety of health problems, including premature aging and cancer.
By neutralizing these free radicals, kojic acid dipalmitate can help to prevent damage to the skin and keep it looking healthy and radiant.
Overall, kojic acid dipalmitate is a versatile and effective skin-lightening agent that has several potential uses in skincare products.
It is particularly effective at reducing the appearance of dark spots and hyperpigmentation, and can also help to improve the overall appearance of the skin.
Whether you are looking to treat melasma or improve the overall health and appearance of your skin, kojic acid dipalmitate may be worth considering.
Kojic acid dipalmitate vs kojic acid
Kojic acid palmitate is a derivative of kojic acid and it is regarded as the best kojic acid version in the kojic acid family so far.
From the above, you can see their structural differences.
Here we skip their differences in physical and chemical properties such as molecular weight, molecular formula, etc, we only compile their differences when they are used in cosmetics as below:
#1 Different water solubilities
Kojic acid dipalmitate is a lipid-soluble substance insoluble in water or ethanol.
If you want to use it for skin-whitening, you must choose oil-based lotions or serums, or it will not be dissolved and absorbed by your skin to achieve whitening effects.
While Kojic acid is insoluble in lipids but soluble in water.
So mix kojic acid into your water-based serums or lotions.
#2 Pigmentation and melasma eliminating effects
Clinical trials have shown that the efficiency of kojic acid dipalmitate is over 50%, and the total effective rate is over 90%, but the effect of kojic acid is much lower.
#3 Whitening efficacy
Kojic acid ester has a stronger inhibitory effect on melanin production than kojic acid.
For example, kojic acid dibutyrate ester is twice powerful in stopping melanin production as kojic acid
As an ester, Kojic acid dipalmitate is more stable than kojic acid.
Because there are two active hydroxyl groups in kojic acid within kojic acid, kojic acid is easier to be oxidized to change color or its character, while kojic acid dipalmitate is more difficult to be oxidized to be something else when these two hydroxy groups are protected, then it is less likely for kojic acid palmitate to go yellow or bad when exposed to air, heat, light, and moisture.
Plus, kojic dipalmitate will not chelate with many metal ions like kojic acid does within the cosmetics, so kojic dipalmitate lotion will not easily go yellow or change color compared with lotions made of kojic acid.
Plus, kojic acid is not stable in an alkaline environment due to its acid nature, while kojic dipalmitate is relatively more stable when the environmental PH value is between 3 to 10.
#5 Compatibility with other whitening ingredients
Kojic acid palmitate is almost compatible with any preservatives and sunscreens used for cosmetics.
It blends well with Vitamin C, alpha arbutin, and Vitamin C derivatives to get a better-whitening effect.
Research has shown that the combined-whitening effect increased exponentially.
As an ester, kojic acid palmitate is neutral to your skin.
But your skin will get itchy when exposed to a formula containing acid such as kojic acid, glycolic acid, etc.
Research has shown that Kojic acid solution is more likely to cause itching or irritation to your skin.
#7 Cost and Purity
After so many advantages of dipalmitate over kojic acid, kojic acid powder has its advantages.
Kojic acid is cheaper, it costs about 1/9 of dipalmitate powder.
Also, the purity of kojic acid powder is 99% as min, and dipalmitate kojic acid purity is 98% as min.
How Is Kojic Acid Dipalmitate Manufactured?
First, we obtain palmitoyl chloride through PC13 and palmitic acid reactions.
Then we let palmitoyl chloride react with kojic acid to obtain the crude product, and then wash and recrystallize it to obtain pure kojic acid dipalmitate crystals
(1) Synthesis of palmitoyl chloride
Add palmitic acid to a three-neck flask, and dissolve it with CC14. Slowly drop PC13 into the flask by a funnel.
We start the reaction at a low stirring speed.
Later when the reaction begins, we let them react at 54~55 degrees celsius for several hours.
later we heat it to 60 degrees and let the reaction goes on for another hour, then we stop the reaction and remove H3P03.
(2) Synthesis of kojic acid dipalmitate
First, dissolve kojic acid in an acetone/pyridine solution in a three-neck flask, then slowly drip the palmitoyl chloride by a funnel and let them react at room temperature.
At the end of the reaction, we wash the target solid with cold water 3 times and filter it on a Brinell funnel.
At last, we recrystallize and dry it under a vacuum to obtain white flaky crystals.
Results and conclusion:
(2.1) Water-free reaction conditions
PCl3 is a pungent-smelling liquid, which will decompose to produce white smoke when exposed to water.
The yellow by-product in the flask during the reaction is phosphoric acid.
Because of the active nature of palmitoyl chloride and PCl3, we must carry out the entire experimental procedure under dry conditions.
(2.2) Different molecular ratios.
When the molar ratio of n(palmitic acid)/n (PCl3) is 1:2, the reaction has the highest conversion rate and the purity of palmitoyl chloride is estimated to be 95% as min.
(2.3) The reaction temperature.
When the reaction temperature is lower than 55 degrees Celsius, the chlorination reaction cannot be carried out completely, and only when the temperature is higher than 55 degrees and the final reaction temperature reaches 60 degrees, the chloride reaction tends to reach completion.
Thus, a suitable reaction temperature for the preparation of palmitoyl chloride is 55-60 degrees, and the final reaction temperature must be raised to 60 degrees Celsius and maintained for 1 hour to get the highest yield.
How To Dissolve Kojic Acid Dipalmitate Powder?
#1. As kojic acid dipalmitate is insoluble in water, it is difficult for you to mix it directly in water-based cosmetics.
Even when you manage to blend in some, it is easy for it to form crystal precipitates afterward.
To solve this crystalization problem, you can add isopropyl palmitate or isopropyl myristate to the oil phase containing kojic acid dipalmitate, heat the oil phase to 80 ℃, and keep it warm for 5 minutes until kojic acid dipalmitate is completely dissolved.
Then add the oil phase to the water phase and emulsify for about 10 minutes.
The pH value of the end products obtained is usually between 5.0 and 8.0.
The recommended dose of kojic acid dipalmitate in cosmetics is 3-5%.
#2. Or you can mix kojic acid dipalmitate powder directly into your creams to get 3~5% whitening creams.
Take 3~5g pure kojic acid dipalmitate powder and mix it in a 100ml-cream by stirring and shaking till all is dissolved.
You can also dissolve it in white oil first before mixing the oil into a cream formulation.
Below is a tutorial video showing how it is done, check it out:
What Is The Hs Code For Kojic Acid Dipalmitate?
Kojic acid dipalmitate is an organic ester.
It belongs to a group of compounds called other heterocyclic compounds containing only oxygen as heteroatoms, with HS Code as 2932999099.
Other Customs Ports are categorizing it into 2936210000 or 2915709000.
Whichever it is, please confirm the HS code details with your import brokers before you begin to handle the customs clearance.
It is better to make sure of the import taxes and duties on it from your Customs Hotline if you don’t have an import broker.
How Much Does Kojic Acid Dipalmitate Powder Cost?
Prices in 2020 have risen almost by 10% against 2019.
For a 100G sample to start, our price is 100USD.
If you only order 1kg as a trial order, our total cost including shipping is 280USD.
For small order quantities of 25kg, our price is about 120USD/KG including shipping cost by express.
For commercial order quantities of 1000kg or more, our fob shanghai price is about 40USD/KG.
If you are interested in getting an idea of landed cost, we are glad to do so.
For more accurate prices updated, please contact us directly.
How To Ship and Store Kojic Acid Dipalmitate?
#1. Shipping methods:
As a pure powder, kojic acid dipalmitate is a very safe and common chemical to be shipped by air.
Chinese testing authorities have categorized them as common and safe goods so we can ship them freely by air or by express/courier for small order quantities or urgent orders.
Due to its high stability, there is no need to put an ice pad within the box to keep it cool during shipping.
For large order quantities, it is also safe and suitable to be shipped by sea because it is the most economic way.
#2. Storage conditions:
For storage, it is better if you can put it in a well-ventilated room with a steady temperature. Please note that the storage temperature can’t be over 25 Degrees Celsius.
Protect it from sunlight and moisture. Shelf life is at least 24 months while properly stored.