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Why You Should Buy Minoxidil Powder From Us?

#1. GMP & DMF Available:

It will be much easier for you to register our raw materials before your production as we have all the docs ready.

#2. Quality Guarantee:

We have standards of USP/EP/CP and you can test the goods by corresponding MOA. We will give you a full refund or change goods for any quality issues.

#3. Reasonable prices:

you will find our price reasonable for the similar quality compared with other Chinese suppliers.

#4. Samples For Testing Available:

You can get our sample for testing before ordering.

What Is Minoxidil?

minoxidil chemical structure

Cas Number: 38304-91-5

Molecular Formula: C9H15N5O

Molecular Weight: 209.253 g/mol

HS Code: 2938909090 (2020.09.11 updated, used to be 2933599090)

Chemical name: 2,4-Diamino-6-piperidinopyrimidine 3-oxide or 6-Piperidin-1-ylpyrimidine-2,4-diamine 3-oxide.

Minoxidil is a white to off-white crystalline powder.

It is barely soluble in water but soluble in propylene glycol, methanol, and ethanol. 

Its solubility in water is 2.2mg/ml, and in propylene glycol is 75mg/ml.

What Is Minoxidil Used For?

Minoxidil was first used as a potent direct-acting peripheral vasodilator to lower blood pressure, but it showed a side effect of increased body hair.

Later minoxidil is widely studied and used for male baldness. 

Studies had shown that about 40% of men experience hair regrowth after 3–6 months.

It must be applied indefinitely for the continued support of existing hair follicles and the maintenance of any experienced hair regrowth.

It is also used with many other ingredients to achieve better hair-growing effects.

We see many of its topical formulations fortified with finasteride, dutasteride, azelaic acid, tretinoin in many hair-growing products.

Studies show that 0.01% of Tretinoin is able to double its efficacy on growing hair back.

The most well-known brands in the market for hair loss are Kirkland and Rogaine.

North America is the leading global market owing to the high adoption of hair-loss treatment products.

According to the American Hair Loss Association, over 80% of men experience hair loss by the age of 50.

Even further, over 21 million women suffer from hair loss problems and about 40% of them opt for active treatments.

The demand for minoxidil is expected to surge due to the aging global population.

According to the United Nations Economic & Social Commission for Asia and the Pacific (ESCAP) in North & Central Asia, the population ratio aged 60 and above will increase to over 24% by 2050.

The video below explains how minoxidil works against hair loss.

The more exciting news is: with the help of other ingredients, the efficacy of minoxidil can be greatly enhanced.

There was a test conducted by scientists for the treatment of hair loss combining tretinoin.

The reason is pretty simple: the scalp of some people who are not responding to minoxidil will respond after applying tretinoin topically for 4 days.

Minoxidil 2% vs 5% vs 10%

There are two common specifications of its topical formulations in the market:

2% type and 5% type, either as topical solutions or aerosol foams or topical liquids. 

You may wonder to yourself: which brand is the best for receding hairline and which specification and form should you choose for better hair regrowth.

According to one study conducted by Duke Dermatopharmacology Study Center in 2002, it showed that In men with AGA (Androgenetic Alopecia), Its 5% topical was superior to 2% and placebo in increasing hair regrowth, and the magnitude of its effect was marked (45% more hair regrowth than 2% topical at week 48).

Men who used the 5% topical also had an earlier response to treatment than those who used 2% topical.

Psychosocial perceptions of hair loss in men with AGA were also improved.

Its topical form (5% and 2%) was well tolerated by the men in this trial without evidence of systemic effects.

Its 2% topical solution was approved for the first time in 1991 to treat female hair loss by Upjohn, applied twice daily.

In more recent years, its first 5% foam for women was approved in 2014, applied once daily.

5% foam no doubt costs less time and is more convenient to apply.

There was one study showing that patients using 5% foam had a mean 32-hair/cm2 or 16% increase, not significantly different from the 14% increase documented in women on the 2% topical solution.

But a 2% difference is better than nothing right?

Polls are showing that women prefer 5% foam to 2% topical solution in general.

By comparison, we conclude that topical 5% works better than 2% for hair growth on both men and women, and 5% solution was found to be more effective than 2% in maintaining existing hair and regrowing lost hair. 

In general, the scientists find that the higher the concentration, the better the effect in terms of treating androgenetic alopecia. 

So now you have your answer, choose the brands with higher concentrations.

However, the higher the concentration is, there will be increased risks of adverse side effects.

Currently, we can only see 10% even 15% formulations in the market, concentrations higher than 15% are not seen yet.

Please be cautious when you are thinking about switching to a higher concentration though, and consult your doctor immediately before you make any decisions.

Is Minoxidil Suitable For Beard Growth?

Partially influenced beard-star James Harden from Houston Rockets of NBA, to grow a thick beard is getting more and more popular.

Are there any finished topical formulations in the market for growing a thick beard?

The ‘official’ answer is NO, as there is no approved formulation in any FDA for beard growth.

But there are many successful cases of men applying it to their faces to get their thick beards.

Actually, you can grow your beard by using any of its topical formulations in the market such as Rogaine, Kirkland, Equate, Tugain, and Lipogaine, etc

What Is The HS Code For Minxodil?

Pure minoxidil powder is an organic compound with a pyrimidine ring. 

It used to belong to one group categorized as other compounds containing pyrimidine rings in the structure (including other compounds containing piperazine rings in the structure), with HS Code as 2933990090. (其他仅含氮杂原子的杂环化合物)

In 2020 it is categorized in China Customs into 2938909090, compounds of other natural or synthetic reconstituted glycosides and their salts, etc.(其他天然或合成再制的苷及其盐等)

If you are buying its medical or cosmetic formulations as finished products, the HS code is different.

The relevant HS code for finished products, such as minoxidil spray, is 3305900000, categorized as other hair-protecting agents. (其他护发品)

In case you are not sure about its hs code, feel free to contact us anytime!

How To Dissolve Minxodil Powder For 1HNMR and HPLC?

When we do the testing of 1nmr spectra for any unverified molecules, we often use DMSO (dimethylsulfoxide) as a solvent.

But it is difficult for us to dissolve it in DMSO.

Our Technician has come up with an idea: a little amount of hydrochloride will greatly increase its solubility in DMSO.

And voila, we get the concentration we need to do our 1hnmr.

You can find our 1hnmr spectrum with hydrochloride for your ref.

For the method of analysis by HPLC, you can just follow the testing procedure in the USP monograph.

Of course, you can always improvise according to the different testing conditions you have.

Anything unclear about the testing methods, welcome to contact us anytime.

We also shoot a video for it, please check the video as below.

How Much Does Minoxidil Powder Cost?

Before you ask for its prices, please note that there are at least 3 grades available in the market: 

1. Pharmaceutical grade with GMP&DMF for dosage manufacturings of Tablets, capsules, etc.

Sure you can use it for ointment, sprays.

Just know that this is the best type of all the 3.

2. Pharm-grade only with Drug Manufacturing License, without GMP/DMF, but suitable for hair-sprays.

3. Cosmetic Grade for topical formulations of cosmetics.

The price for commercial order quantity (over 100kg) of pharmaceutical grade with GMP and DMF in China is around 380~400usd/kg.

The cost of non-GMP type pharm-grade material is around 330USD/kg.

The price for commercial order quantities (over 100kg) of cosmetic grade is around 300usd/kg.

How To Ship and Store Minoxidil Powder?

#1. Shipping methods:

First thing first, minoxidil powder is tested to be very safe to be shipped by air.

It is not flammable, explosive, oxidizing, toxic, etc.

It is not a dangerous chemical in any way.

So we are allowed to ship it by courier or air for small quantities.

For commercial quantities, it is also ok to be shipped by sea or inland methods.

As it is a safe chemical, no special packing is required for its shipping either unlike goods of dangerous type 6.1 or other types.

#2. Shipping and storage conditions:

Stability testing has proved that minoxidil powder is stable for 2 years at room temperature when it is properly stored.

Just make sure it is protected from direct sunlight and moisture.

Therefore, we can ship and store it at normal temperature without any cold-chain requirements.

Technical Documents Download

References

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