Buy 99.9% Tofacitinib Citrate Powder In Stock

Why Buy Tofacitinib Citrate Powder From Us?

#1. Fast shipment: We have 5kilo tofactinib powder as running stock for fast shipment. Contact us for a quick order and we can ship it out within 2 days.

#2. Guaranteed quality: 100% refund if quality not meeting our purity requirements. Our steady manufacturing process always keeps our yield high and impurity below limits.

#3. Low moq: our MOQ is 50G but Subject To Negotiation.

#4. Highest purity: our purity standard is 99.5% as min.

#5. Free samples for testing: we have FREE Samples for your quality approval. 

Looking For Bulk Tofacitinib Citrate Manufacturers? Contact Us Now!

What is Tofacitinib Citrate?

Tofacitinib citrate Structure
Tofacitinib Citrate Chemical Structure

Tofacitinib citrate is a white to off-white crystalline powder. It is insoluble in water and ethanol but very soluble in DMSO and N,N-Dimethylacetamide.

Cas no: 540737-29-9

Molecualr Formula: C16H20N6O • C6H8O7

Molecular Weight: 504.5g/mol 

Chemical name: 2-hydroxypropane-1,2,3-tricarboxylic acid;3-[(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-3-oxopropanenitrile.

Other names: Xeljanz xr; 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile 2-hydroxypropane-1,2,3-tricarboxylate, 3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile 2-hydroxypropane-1,2,3-tricarboxylate; 3-{(3r,4r)-4-methyl-3-[methyl-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidin-1-yl}-3-oxo-propionitrile citrate salt.

What Can Tofacitinib Citrate Be Used For?

People use it to treat adults with psoriatic arthritis, moderately to severely active rheumatoid arthritis and moderately to severely active ulcerative colitis. It is one of our new pharmaceutical ingredients along with 99% Emeramide Powder, Pure Tafamidis powder.

Recenlty researches have shown that it can be used for for alopecia and vitiligo. Unlike minoxidil powder, the dosage forms of it for alopecia are not limited to topically applied formulations, it has dosage forms of tablets for alopecia too.

Please note, it is the first oral JAK inhibitor approved for ulcerative colitis by FDA.

It also showed effectiveness on vitiligo. As a matter of fact, there are many patient assistance programs going on for more potential treatments.

How Much Does Tofacitinib Powder Cost?

The cost from octagonchem is about 10500USD/KG as FOB Shanghaifor commercial order quantities such as 10kg or more.

For order quantities between 10~50kg, our price is about 10000USD/KG

Costs are subject to fluctuations. Please contact us directly for more accurate prices for different quantities.

If you need its api for research and have not decided where to buy, you can check its prices from other companies below for your ref.

But most importantly, please test our free samples for quality comparison before you make your final decisions.

Buy 99.9% Cheap Tofacitinib Citrate Powder

Price from sigma is 408usd/25mg

Buy 99.9% Cheap Tofacitinib Citrate Powder

Offer from selleck chem is around 550usd/50mg

tofacitinib price from medchemexpress

Unit price from medchemexpress is 1000usd/500mg

As GMP certificate for tofacitinib citrate is not available in China yet, this product is exported by chemical name or as intermediates.

Now check its prices from pharmacompass so you will have a general price idea from other countries.

tofacitinib citrate export prices from pharmacompass

As you can see the prices from China is 11352 usd per kg, though by a very small quantity. Export prices from other countries are around 30000 usd/kg, so don’t be so surprised when you receive offer of 40000usd.

We can see that its export prices from India is HIGHER than prices from China, and there is a greater chance that India is importing tofacitinib and reselling it to other countries. Or they are buying the interdiates and selling these APIs, or making formulations in India.

So if you are looking to buy tofacitinib online, India will be a wrong direction to look, please note.

What Are Tofacitinib Citrate Side Effects?

Common side effects include diarrhea, headache, and high blood pressure. Serious side effects may include but not limited to infections, cancer, and pulmonary embolism.

Please take doses of finished formulations strictly according to the advice of your doctor.

What Is HS code for Tofacitinib Citrate ?

You have to know its hs code before you order it. Hs code will give you details on the import duties and taxes imposed by your country customs.

For pure powder, it is categorized as an organic heterocyclic salt belonging to a group of chemical compounds called ‘other heterocyclic compounds containing only nitrogen as heteroatoms’, with HS Code as 2933990099.

If you are buying its tablets or capsules, it will be another hs code.

Hs code for its tablets or capsules is 3004900000. This is the code for its finished formulations. Different customs may have different categorizations, but at least it should start with 3004.

Tofacitinib citrate hs code look up

Testing Methods For Tofacitinib Citrate Powder By NMR/HPLC

Once you have received the sample, you have to know 2 simple testing methods to verify its quality. Through 1hnmr we can make sure the structure is correct, and hplc will show its purity and impurities.

#1. Solvent used for 1HNMR

To run nmr, you have to dissolve the target molecule first, you need to find the right solvent first.

As we have mentioned its solubility above, it is insoluble in water and ethanol but soluble in DMSO, so you can use DMSO to dissolve it to run 1hnrm testing. Our spectrum tested by this method is down below in our download section, please check.

 

tofacitinib hplc gradient elution method
patent for tofacitinib hplc method

#2. Method for HPLC testing

To run hplc testing on purity, we must choose the right column and mobile phase, no much importance on the brands for hplc equipments.

Column: C18; size: 4.6*50mm; mobile phase: B(acetonitrile), A(0.02% NH4Ac); Gradient elution(B%).

Of course, this is just our method for moa and there are other different methods out there for your to explore. We found one patent for the hplc method too, please check below.

Though it is in Chinese, if you have done hplc before, you can see that the patent is using a longer column, with different Mobile Phase A and B by the unit.

From the table you can also see the gradient elution method, the ratio of A/B by the minute(Their whole running time is 55 min)

How To Ship and Store Tofacitinib Powder?

Tofacitinib is a common chemical suitable for shipping by air or courier. It is safe and non-poisonous.

Bio-satety tests have showed that its LD50(rat oral) is 500mg/kg. It is not flammable or explosive. You can download its certificate of safe air transportation for your ref.

For more material safety data, check our msds below.

Buy 99.9% Cheap Tofacitinib Citrate Powder
shipping chemicals by air

It has good stability under room temperature if it is protected from moisture and sunlight, so you can ship it through sealed packages or containers at normal temperature, no need for cold-chain shipment.

For the storage, the shelf life at stable room temperature is at least 2 years, on the basis that you protect it from moisture and light. If you want a longer shelf life than 24 months, feel free to store it under 2~8 Degrees Celsius.