Looking For Largest Tofacitinib Manufacturer In China?
Contact Us Now!

Why You Should Buy Tofacitinib Citrate Powder From Us?

#1. Fast shipment:

We have 5kilo powder as running stock for fast shipment. Contact us for quick orders and we can ship them out within 2 days.

#2. Guaranteed quality:

100% refund if the quality does not meet our purity requirements. Our steady manufacturing process always keeps our yield high and impurity below limits.

#3. Low MOQ:

Our MOQ is 100G but Subject To Negotiation.

#4. The highest purity you can ever find:

Our purity standard is 99.5% as min.

What is Tofacitinib Citrate?

Tofacitinib citrate Structure

Cas no: 540737-29-9

Molecualr Formula: C16H20N6O • C6H8O7

Molecular Weight: 504.5g/mol 

Chemical name: 2-hydroxypropane-1,2,3-tricarboxylic acid;3-[(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-3-oxopropanenitrile.

Other names: Xeljanz xr; 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile 2-hydroxypropane-1,2,3-tricarboxylate, 3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile 2-hydroxypropane-1,2,3-tricarboxylate; 3-{(3r,4r)-4-methyl-3-[methyl-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidin-1-yl}-3-oxo-propionitrile citrate salt.

Tofacitinib citrate is a white to off-white crystalline powder.

It is insoluble in water and ethanol but very soluble in DMSO and N, N-Dimethylacetamide.

Tofacitinib is the first oral JAK inhibitor in history ever approved for ulcerative colitis by FDA.

What Is Tofacitinib Used For?

Tofacitinib is mainly used to treat psoriatic arthritis, moderately to severely active rheumatoid arthritis, and moderately to severely active ulcerative colitis.

It is one of our new pharmaceutical ingredients along with 99% Emeramide Powder, Pure Tafamidis powder.

The latest researches have shown that tofacitinib can be used for alopecia and vitiligo.

Unlike minoxidil powder, the dosage form of tofacitinib for alopecia is not limited to topically applied formulations, it also has dosage forms of tablets for alopecia.

But it also showed efficacy against vitiligo.

As a matter of fact, there are many of its patient-assistance programs going on for other potential treatments.

How Much Does Tofacitinib Powder Cost?

If you only need an estimated price idea for your research budget purpose, 100Grams our price is around 1500USD.

If you have larger orders than that, our cost is about 10500USD/KG as FOB Shanghai for commercial order quantities such as 10kg or more.

For order quantities between 10~50kg, our price is about 10000USD/KG

Costs are subject to fluctuations. Please contact us directly for more accurate prices for different quantities.

If you need its API for research and have not decided where to buy, you can check its prices from other companies below for your ref.

But most importantly, please test our Free Samples for quality comparison before you make your final decisions.

tofacitinib price from sigma
Price from sigma is 408usd/25mg
Buy Tofacitinib 540737-29-9 With Best Prices
Offer from selleck chem is around 550usd/50mg
tofacitinib price from medchemexpress
Unit price from medchemexpress is 1000usd/500mg

As the GMP certificate for tofacitinib citrate is not available in China yet, this product is exported by chemical name or as intermediates.

Now check its prices from Pharmacompass so you will have a general price idea from other countries.

tofacitinib citrate export prices from pharmacompass

As you can see the price from China is 11352 USD per kg, though by a very small quantity.

Export prices from other countries are around 30000 USD/kg, so don’t be surprised when you receive offers of 40000usd.

We can see that its export prices from India are HIGHER than prices from China.

There is a greater chance that India is importing tofacitinib and reselling it to other countries.

Or they are buying the intermediates and selling these APIs, or making formulations in India.

So if you are looking to buy tofacitinib online, India will be the wrong direction to look, please note.

What Are Tofacitinib Citrate Side Effects?

The common side effects of tofacitinib include diarrhea, headache, and high blood pressure.

Serious side effects may include but are not limited to infections, cancer, and pulmonary embolism.

Please take doses of finished formulations strictly according to the advice of your doctor.

What Is The HS Code For Tofacitinib ?

You have to know its hs code before you order it.

The HS code will give you details on the import duties and taxes imposed by your country’s customs.

For its pure powder, it is categorized as organic heterocyclic salt.

It belongs to a group of chemical compounds called other heterocyclic compounds containing only nitrogen as heteroatoms, with HS Code as 2933990099.

If you are buying its tablets or capsules, it will be another hs code.

Hs code for its tablets or capsules is 3004900000.

This is the code for its finished formulations.

Different customs may have different categorizations, but at least it should start with 3004.

How To Test Tofacitinib Powder By NMR/HPLC?

Once you have received the sample, you have to know 2 simple testing methods to verify its quality.

Through 1hnmr we can make sure the structure is correct, and HPLC will show its purity and impurities.

#1. The solvent used for 1HNMR

To run NMR, you have to dissolve the target molecule first, you need to find the right solvent first.

As we have mentioned its solubility above, it is insoluble in water and ethanol but soluble in DMSO, so you can use DMSO to dissolve it to run 1hnrm testing.

Our spectrum tested by this method is down below in our download section, please check.

#2. Method for HPLC testing

To run HPLC testing on purity, we must choose the right column and mobile phase, not much importance on the brands for HPLC equipment.

Column: C18; size: 4.6*50mm; mobile phase: B(acetonitrile), A(0.02% NH4Ac); Gradient elution(B%).

Of course, this is just our method for moa and there are other different methods out there for your to explore. We found one patent for the HPLC method too, please check below.

Though it is in Chinese, if you have done HPLC before, you can see that the patent is using a longer column, with different Mobile Phases A and B by the unit.

From the table, you can also see the gradient elution method, the ratio of A/B by the minute(Their whole running time is 55 min)

How To Ship and Store Tofacitinib Powder?

Tofacitinib is a common chemical suitable for shipping by air or courier. It is safe and non-poisonous.

Bio-safety tests have shown that its LD50(rat oral) is 500mg/kg.

It is not flammable or explosive. You can download its certificate of safe air transportation for your ref.

For more material safety data, check our MSDS below.

shipping chemicals by air

Tofacitinib is very stable under room temperature if it is protected from moisture and sunlight.

So you can ship it through sealed packages or containers at normal temperature, no need for cold-chain shipment.

For the storage, the shelf life at stable room temperature is at least 2 years, on the basis that you protect it from moisture and light.

If you want a longer shelf life than 24 months, feel free to store it under 2~8 Degrees Celsius.

octagonchem packing options for chemicals

Technical Documents Download


Other New Molecules You May Like