Buy Pure Tafamidis With The Best Price
Why you should buy tafamidis from us?
#1. Fast shipment: your order will be sent out within 3 days if not sooner.
#2. High purity with consistent quality: our synthesis yield is very stable with less impurities. Our enterprise standard for purity is 99% as min.
#3. Quality guarantee: you get full refund for any quality issues. We also run a 3rd-party testing for your commerical orders to be 100% sure.
#4. Competitive prices: you can get the best price for the same quality chemicals with testing spectra and refund policies.
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What is Tafamidis?
Appearance: white to off-white powder
Cas number: 594839-88-0
Chemical name: 2-(3,5-Dichlorophenyl)-6-benzoxazole carboxylic acid
Molecular Weight: 308.11
Molecular Formula: C14H7Cl2NO3
It is a novel active pharmaceutical ingredient used to delay the loss of peripheral nerve function in adults with familial amyloid polyneuropathy (FAP). Pfizer is the marketer and developer. It works by stabilizing the protein and transthyretin, which is made up of four strands. In people with FAP, these strands would separate and form clumps to harm nerves.
Is tafamidis available in the US?
Yes, in March 2019, it was approved by the FDA for the treatment of transthyretin-mediated cardiomyopathy.
Its brands include Vyndaqel and Vyndamax.
The FDA approved its meglumine salt an orphan drug, while European Medicines Agency made its free base an orphan drug rather than meglumine salt in Europe.
Tafamidis vs tafamidis meglumine
Its Meglumine salt Structure
There are two forms of it in the USA: the meglumine salt and its free base.
Despite their differences in chemical physical and chemical properties, those two have the same active moiety and the effect in the body is almost the same. Their main differences are as below:
Free base costs a little more than meglumine salt.
#2. Stability and solubility in water.
Meglumine salt is more stable than the free base. It also has better solubility in water.
Due to the better recrystalization effects of the meglumine salts, meglumine salt is easier to be refined to get higher purities as fine crystals.
What are tafamidis side effects?
Before you take the medicine, you need to ask the doctor or pharmacist of the possible side effects.
The most common side effects include urinary tract infection, vaginal infection, diarrhea, and upper abdominal pain. So please take extra care before you take it.
What is Tafamidis synthesis route?
2-step Synthesis To Get Pure Tafamidis
As you can see from above, it is synthesized in 2 steps: first through addition reaction of 3,5-Dichlorobenzoyl chloride and 4-Amino-3-hydroxybenzoic acid. Second step is dehydration reaction to get pure crystals.
What is tafamidis price?
For its 100G pure meglumine salt, our Fob Shanghai Price is around 120USD/G.
For 1kg or more, the cost is around 100USD/G
For more accurate prices, please contact us directly.
Other sources to buy tafamidis pure powder
If you are a patient or an individual, you can get this drug from the USA, Europe, Japan now with a prescription from your doctor.
But if you are a scientist or researcher needing it for research, email us or call us now! We have pure powder of 99% as min for fast shipment.
We can provide NMR and HPLC spectra of the latest batch for your confirmation before your order.
Many reagent companies are buying it from us. You can check those prices from them as below for your ref:
Price from selleck chem is around 800usd/100mg
Price from chem scene is 450usd/100mg
Price from adooq is 90usd/10mg
Price from MCE is around 1000usd/100mg
From the prices above you can see the best price you can get is from chemscene. Their price is 450usd/100mg without shipping.
The cost for commercial order quantities from octagonchem is 120usd/g. If you need it for research, try our sample to verify purity and quality first before you make your final decisions.