99% Tafamidis API Of ISO Factory

Why Choose Us As Your Tafamidis Supplier

#1. Fast shipment:

Your order will be sent out within 3 days if not sooner.

#2. High purity with consistent quality:

Our synthesis yield is very stable with fewer impurities. Our enterprise standard for purity is 99% as min.

#3. Quality guarantee:

You get a full refund for any quality issues. We also run 3rd-party testing for your commercial orders to be 100% sure.

#4. Competitive prices:

You can get the best price in China from us for the 99%-type chemicals.

You can check around and you will see.

Looking For Tafamidis Manufacturers In China? Contact Us Now!

What is Tafamidis?

Tafamidis 594839-88-0 Chemical Structure

Appearance: white to off-white powder

Cas number: 594839-88-0

Chemical name: 2-(3,5-Dichlorophenyl)-6-benzoxazole carboxylic acid

Molecular Formula: C14H7Cl2NO3

Molecular Weight: 308.11 g/mol

Tafamidis is a novel active pharmaceutical ingredient used to delay the loss of peripheral nerve function in adults with familial amyloid polyneuropathy (FAP).

Pfizer is its marketer and developer.

It works by stabilizing the protein and transthyretin, which is made up of four strands.

In people with FAP, these strands would separate and form clumps to harm nerves.

Is Tafamidis Available In The US?

Yes, in March 2019, it was approved by the FDA for the treatment of transthyretin-mediated cardiomyopathy.
Its brands include Vyndaqel and Vyndamax. 

The FDA approved its meglumine salt as an orphan drug, while the European Medicines Agency made its free base an orphan drug rather than meglumine salt in Europe.

Tafamidis vs tafamidis meglumine

99% Tafamidis API
Meglumine salt Structure
Pure Tafamidis for research In Brown Bottle

There are two forms of it in the USA: the meglumine salt and its free base.

Despite their differences in chemical physical and chemical properties, those two have the same active moiety and the effect on the body is almost the same. Their main differences are as below:

#1. Price

The free base costs a little more than meglumine salt.

#2. Stability and solubility in water.

Meglumine salt is more stable than the free base. It also has better solubility in water.

#3. Purity

Due to the better recrystallization effects of the meglumine salts, meglumine salt is easier to refine to get higher purities as fine crystals.

What Are Tafamidis Side effects?

Before you take the medicine, you need to ask the doctor or pharmacist about the possible side effects.

The most common side effects include urinary tract infections, vaginal infections, diarrhea, and upper abdominal pain. So please take extra care before you take it.

What Is Tafamidis Synthesis Route?

tafamidis synthesis route

2-step Synthesis To Get Pure Tafamidis

As you can see from above, it is synthesized in 2 steps:

First through the addition reaction of 3,5-Dichlorobenzoyl chloride and 4-Amino-3-hydroxybenzoic acid.

The second step is the dehydration reaction to get pure crystals.

How Much Does Tafamidis API Cost?

If you are looking for pure powder for lab research, please check our quotes below:

For its 100G pure meglumine salt, our Fob Shanghai Price is around 120 USD/G.

For 1kg or more, the cost is around 100 USD/G

For more accurate prices, please contact us directly.

Other Sources To Source Tafamidis

If you are a patient or an individual, you can get this drug from the USA, Europe, and Japan now with a prescription from your doctor.

But if you are a scientist or researcher needing it for research, email us or call us now!

We have pure powder of 99% as min for fast shipment.

We can provide NMR and HPLC spectra of the latest batch for your confirmation before your order.

Many reagent companies are buying it from us. You can check those prices from them below for your ref:

Price from selleck chem is around 800usd/100mg
Price from chem scene is 450usd/100mg
Price from adooq is 90usd/10mg
Price from MCE is around 1000usd/100mg

From the prices above you can see the best price you can get is from chemscene.

Their price is 450 USD/100mg without shipping.

The cost for commercial order quantities from octagonchem is 120usd/g.

If you need it for research, try our sample to verify purity and quality first before you make your final decisions.

Manufacturer Documents Download

References

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