99% Rapamycin Powder Of GMP Manufacturer In China
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Why You Should Choose Us As Your Rapamycin Supplier?
#1. GMP Approved:
Our manufacturing line is certified Chinese National Medical Products Administration.
Email us for our GMP certificate if you need it.
#2. Low MOQ:
We know it is not a cheap product, but we are willing to accept orders starting with small quantities, such as 1G, 5G, and 10G.
We will do everything to meet the needs of our customers, no matter you are running a pharmacy, or you may need it for research.
#3. Short lead time:
Though repacking APIs from GMP factories has to follow strict procedures, we have managed to send out the goods to our customers within 3~4 days after order confirmation.
What Is Rapamycin (Sirolimus)?
Cas number: 53123-88-9
Molecular formula: C51H79NO13
Molecular weight: 914.17 g/mol
Chemical Name: (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone
HS Code: 2941909099（Other antibiotics-其它抗菌素）
Rapamycin, also known as sirolimus, is an off-white to yellowish powder mainly used as an immunosuppressant agent.
It is practically insoluble in water but easily soluble in DMSO and soluble in ethanol.
Its solubility in DMSO can reach 200mg/ml and 50mg/ml in ethanol.
Rapamycin is macrocyclic antibiotic with potent immunosuppressive activity that is used alone or in combination with calcineurin inhibitors and corticosteroids to prevent cellular rejection after renal transplantation.
Its therapy can be associated with mild serum enzyme elevations and it has been linked to rare instances of clinically apparent cholestatic liver injury.
Clinically it is also used to treat rare lung diseases.
But its main usage is to prevent the rejection of kidney transplants.
It works by inhibiting T cells and B cells to get the patients through after the surgery.
What Is Rapamyicn Used For?
Rapamycin is a medication that belongs to a class of drugs known as immunosuppressants.
It is commonly used to prevent the rejection of transplanted organs, such as kidneys, livers, and hearts, in patients who have undergone organ transplant surgery.
It works by inhibiting the activation of certain immune cells, which helps to suppress the immune system and reduce the risk of organ rejection.
It is typically used in combination with other immunosuppressant medications, such as corticosteroids and calcineurin inhibitors, to achieve the desired effect.
It may also be used off-label to treat certain autoimmune conditions, such as lupus and scleroderma, and certain types of cancer, such as lymphoma and breast cancer.
In these cases, it is believed to work by inhibiting the proliferation and activation of immune cells and cancer cells, respectively.
Rapamycin is generally well-tolerated, but it can cause side effects, such as nausea, diarrhea, and an increased risk of infections.
It is important to discuss any potential side effects with a healthcare provider and report any adverse reactions to the medication.
How Is Rapamyicn Produced?
There are several different methods for producing rapamycin, and the specific process used will depend on the intended use of the final product and the starting materials available.
Here is a general outline of the steps involved in producing rapamycin:
Isolation of rapamycin-producing bacteria:
The first step in producing rapamycin is to isolate the bacteria that naturally produce the compound. This is typically done by collecting soil samples from areas where the bacteria are known to grow and then identifying and isolating the specific strains that produce rapamycin.
Cultivation of the bacteria:
Once the rapamycin-producing bacteria have been isolated, they need to be grown in large quantities in order to produce a sufficient amount of the compound. This is typically done in a fermentation process, where the bacteria are cultured in a nutrient-rich medium under controlled conditions.
Extraction of rapamycin:
Once the bacteria have been grown, the rapamycin must be extracted from the culture. This is typically done by adding a solvent to the culture, which dissolves the rapamycin and allows it to be separated from the bacteria and other components of the culture.
Purification of rapamycin:
After extraction, the rapamycin must be purified to remove impurities and other contaminants. This is typically done through a series of steps including filtration, crystallization, and chromatography.
Formulation of the final product:
Once the rapamycin has been purified, it is typically formulated into a final product for use in various applications.
This may involve mixing the rapamycin with other ingredients to create a specific dosage form, such as a tablet or injection.
It is important to note that the production of rapamycin is a complex process that requires a high level of skill and expertise.
It should not be attempted by individuals without appropriate training and experience in this area.