#1. Why You Need Extended-Released Tabs For Dogs

If it is a common tablet, the tab will have a short half-life.

Therefore, the dogs will not only suffer from frequent administrations but also will increase the probability of sudden death in sick animals due to the rapid peak rate and high peak concentration.

If we have extended-release tablets, we can reduce the original twice-daily administration to once daily.

Also, the slow-release tabs can reduce pimobendan peak concentration below the dose that would trigger sudden death.

It will also prolong the peak time, and then achieve better clinical treatment effects.

#2. Ingredients for the Extended-Release Tabs(100MG)

Pimobendan(Active ingredient 1mg)+{citric acid, starch, lactose, artificial beef orthodontic agent, povidone, colloidal Silicone dioxide, Magnesium Stearate, and other components}(Excipients 99mg).

We have also separated our excipients into several classes below.

#2.1 Slow-release materials: 1 of or the combination of Sodium alginate, hydroxypropyl methylcellulose, carbomer (Dosage 5-20% (W/W))

#2.2 Fillers: Starch and lactose. [10-15% (W/W) for starch, 10-15% (W/W) for lactose]

#2.3 Binders: Povidone at 2.5% (W/W)

#2.4 Lubricants: Magnesium stearate by 0.5% (W/W)

#2.5 Flavor modifiers: One or more combinations of dried liver or muscle powder of cattle, sheep, pigs, poultry, etc., fruit-flavored spices, vanilla spices, preferably chicken liver powder by 6-11% (W/W)

#3. Compounding Procedure

#3.1 At first, we will prepare the solid dispersion of pimobendan with citric acid by the ratio of 1/50.

We dissolve pimobendan and citric acid in the water, vacuum dry, crush the dried solid powder, pass it through a 200 mesh sieve, and put it aside for later use.

#3.2 Mix the solid dispersion with slow-release materials, fillers, 80% of the Flavor modifiers, and 30% of the binder evenly to get the mixed powder.

#3.3 Get soft material by adding the binder solution of ethanol/water (30/70).

The solution is prepared by mixing the remaining 70% binder in ethanol/water.

#3.4 Make granulates with the soft material produced above.

Dry the granules at 60°C for one hour, and we get even granules.

#3.5 Spread lubricants and the remaining 20% of the flavor modifiers to the granules and mix them well.

#3.6 Put the flavored granules into tableting machines and we get the final extended-release tablets.

For all the Vets, don’t stop here. This can also be applied to the production of other sustained-release tabs.