Buy 99% Bulk Pimobendan Powder

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Why You Should Buy Pimobendan Powder From Us?

#1. High purity:

Our pure powder is 99% as min, single impurity is less than 0.1%.

#2. Samples for quality approval available:

If you want to test our samples first, contact us to arrange the samples.

#3. Low MOQ:

Though our standard packing is 1kg, our MOQ starts from 50g.

#4. Fast and safe shipment:

Tracking can be provided within 3~4 days after your order.

We have very able agents to make sure you get it safely.

What Is Pimobendan?

pimobendan chemical structure
Chemical Structure

Cas number: 74150-27-9

Molecular Formula: C19H18N4O2

Molecular Weight: 334.4 g/mol

Pimobendan, also named pimobendane, is a white to off-white crystalline powder, practically insoluble in water, freely soluble in DMF (Dimethylformamide), slightly soluble in acetone, and methanol.

Pimobendan is a non-sympathomimetic and glucagon intrinsic drug and has a vasodilatory effect.

It is a hormone mainly for veterinary use for pets with heart conditions.

As one of the most widely used hormone pet meds along with Trilostane, pimobendan is marketed under brands of Vetmedin.

Pimobendan is used clinically mainly due to its myocardial stimulation.

The stimulation is exerted mainly through a dual mechanism of action: an increase in cardiac myofilament calcium sensitivity and an enhancement of phosphodiesterase inhibition (type III).

Pimobendan mainly works through the inhibition of phosphodiesterase III activity.

What Is Pimobendan Used For?

Pimobendan is mainly used to treat mild, moderate, or severe congestive heart failure due to atrioventricular valve insufficiency or myocardial hypertrophy.

According to different situations, pimobendan may also be used combined with other drugs for congestive heart failure such as some diuretics, furosemide, etc.

Its pure powder is often compounded into oral liquids, in form of oral solutions or suspensions for dogs and cats with heart conditions.

It is mainly indicated for dogs with heart failure:

Dogs with class II heart failure: fatigue, shortness of breath, and coughing usually when the dog exceeds the usual amount of exercise.

Dogs with class III heart failure: normal at rest, but relatively poor exercise capacity.

Dogs with Class IV heart failure: little to no exercise capacity, even at rest.

It is also made into tablets or capsules by the vet with certain flavors your pets love.

Research has shown that it can improve the quality of life for pets with congestive heart failure compared with benazepril.

To achieve better medical effects, it should be given by mouth to your pets on empty stomach for short-term use one hour before food.

If it is for chronic uses of your pet, it is ok to be taken with food, just make it routine so your pet can better get used to it.

How To Make Extended-Release Pimobendan Tablets For Dogs?

#1. Why You Need Extended-Released Tabs For Dogs

If it is a common tablet, the tab will have a short half-life.

Therefore, the dogs will not only suffer from frequent administrations but also will increase the probability of sudden death in sick animals due to the rapid peak rate and high peak concentration.

If we have extended-release tablets, we can reduce the original twice-daily administration to once daily.

Also, the slow-release tabs can reduce pimobendan peak concentration below the dose that would trigger sudden death.

It will also prolong the peak time, and then achieve better clinical treatment effects.

#2. Ingredients for the Extended-Release Tabs(100MG)

Pimobendan(Active ingredient 1mg)+{citric acid, starch, lactose, artificial beef orthodontic agent, povidone, colloidal Silicone dioxide, Magnesium Stearate, and other components}(Excipients 99mg).

We have also separated our excipients into several classes below.

#2.1 Slow-release materials: 1 of or the combination of Sodium alginate, hydroxypropyl methylcellulose, carbomer (Dosage 5-20% (W/W))

#2.2 Fillers: Starch and lactose. [10-15% (W/W) for starch, 10-15% (W/W) for lactose]

#2.3 Binders: Povidone at 2.5% (W/W)

#2.4 Lubricants: Magnesium stearate by 0.5% (W/W)

#2.5 Flavor modifiers: One or more combinations of dried liver or muscle powder of cattle, sheep, pigs, poultry, etc., fruit-flavored spices, vanilla spices, preferably chicken liver powder by 6-11% (W/W)

#3. Compounding Procedure

#3.1 At first, we will prepare the solid dispersion of pimobendan with citric acid by the ratio of 1/50.

We dissolve pimobendan and citric acid in the water, vacuum dry, crush the dried solid powder, pass it through a 200 mesh sieve, and put it aside for later use.

#3.2 Mix the solid dispersion with slow-release materials, fillers, 80% of the Flavor modifiers, and 30% of the binder evenly to get the mixed powder.

#3.3 Get soft material by adding the binder solution of ethanol/water (30/70).

The solution is prepared by mixing the remaining 70% binder in ethanol/water.

#3.4 Make granulates with the soft material produced above.

Dry the granules at 60°C for one hour, and we get even granules.

#3.5 Spread lubricants and the remaining 20% of the flavor modifiers to the granules and mix them well.

#3.6 Put the flavored granules into tableting machines and we get the final extended-release tablets.

For all the Vets, don’t stop here. This can also be applied to the production of other sustained-release tabs.

How Much Does Pimobendan Powder Cost?

If you have an Animal Compounding Pharmacy and you need pure powder to compound formulations for dogs, you can check our offer below.

As for our price of pure powder of 99%, it depends on your order quantities.

If you only need 50g, our total price with free shipping is around 500~600usd.

If you buy it commercially by 10 kilos or more, our wholesale price is around 5000~5500usd/kg.

For more accurate costs for other quantities, feel free to contact us anytime.

If you are a scientist or a researcher needing pure powder for research, you can check its prices from other online vendors below.

Other Pimobendan Vendors Online

If you only need MGs for your scientific research, you can check other reliable sources of it as below:

pimobendan price from apexbt is 1729usd for 500mg

Cost from apexbt is 1729usd for 500mg

pimobendan price from sigma is 375usd for 50mg

price from sigma is 375usd for 50mg

pimobendan price from trc-canada is 580usd for 100mg

Trc-canada is selling by 580usd for 100mg

As you can see from the prices above, the best offer you can find is from TRC, as 580usd for 100mg. It is a not bad thing for you to check more sources before you buy.

Either way, you can contact us for a free quote anytime.

Technical Documents Download

References

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