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Why You Should Buy Emeramide Powder From Us?

#1. Consistent Quality:

The bulk powder has a purity of 99% as min and impurities are controlled below 0.5% for every batch.

We have 1HNMR and HPLC spectrum for quality proof.

#2. Fast Delivery Channel with Stable Stock:

Customers are happy to receive chemicals safely in their hands through our delivery channel.

Whether you are a buyer from UK or US, we have able courier agents to handle the shipping for you.

400G freshly produced in stock by End of Sep 2021.

What is Emeramide? (Irminix)

Best 99% Emeramide Powder (NBMI)
Chemical Structure
Best 99% Emeramide Powder (NBMI)
X-Ray Stucture

Cas number: 351994-94-0

Molecular Weight: 284.4g/mol

Molecular Formula: C12H16N2O2S2

Emeramide, also known as BDTH2, NBMI, or [N1, N3-Bis-(2-Mercaptoethyl) Isophthalamide], is a white to off-white solid synthesized in the lab.

It is insoluble in water but easily soluble in fat or lipids.

But it is soluble in DMSO, which makes its 1HNMR testing in DMSO solution easier.

Emeramide was previously used for treating mercury-contaminated soil and water, but later it is also found to be able to detox animals with mercury poisoning.

It is one of our recently developed novel active molecules, a brand-new lipid-soluble antioxidant, and a novel heavy metal chelator (Mainly used for mercury poisoning).

You can tell from its chemical structure that this molecule is specifically designed to capture heavy metals, especially mercury(II) in ground soil and water.

Due to the small demand from the current market, we are still not producing it commercially till today.

Even orders of Kilos are still done in our lab.

How emeramide cholates Hg

It is the most well-known reagent so far used for the precipitation of mercury from water.

The precipitate of BDT-Hg or NBMI-Hg is so stable that it will suck and capture almost all mercury in water, even though the mercury concentration level in aqueous solutions is very low. 

What makes BDTH2 better is that BDTH2 will still be binding mercury even after it is oxidized into disulfide.

It will work in all sorts of water solutions, no matter what the PH of the solution is: acidic, basic, or neutral.

What Heavy Metals Can Emeramide Chelate? 

heavy metals in water can be chelated by emeramide powder
heavy metals emeramide can chelate
Heavy Metals

Except for the notorious mercury, BDTH2 is also proved to be effective in precipitating other divalent metals in water such as copper, lead, arsenic, selenium, cadmium, etc.

Scientific studies show that BDTH is able to chelate mercury, lead, cadmium, copper, manganese, zinc, iron across the blood-brain barrier.

Mercury (Hg), especially from the groundwater, goal ore, wastewater of battery-recycling plants, coal tailings, and contaminated soil can be effectively chelated so the water can be cleaned.

What Are The Symptoms of Heavy Metal Poisoning?

heavy-metal poisoning symptoms

There are two types of heavy metal poisoning, acute and chronic poisoning.

What we are talking about here is chronic poisoning by heavy metals.

We can find heavy metals everywhere, in the water, air, foods, and toys, etc.

If you live in a heavy-metal polluted environment for a while, there are risks that you may get heavy metal poisoning.

Common symptoms of heavy metal poisoning include nausea, vomiting, shortness of breath, diarrhea, abdominal pain, tingling of your hands and feet, chills, and weakness.

It is better to see a doctor right away when you have these symptoms when you have lived in such environments polluted by high-level heavy metals. 

How Is Emeramide Synthesized In Lab?

Emeramide synthesis route
Synthesis Route In The Lab

The synthesis of NBMI can be done in one-step synthesis as shown on the left.

We have to make sure that the reaction takes place at a low temperature.

We first dissolve 2-aminoethylthiol hydrochloride in chloroform and triethylamine and place the flask in an ice bath with stirring.

Then we add the solution containing Isophthaloyl chloride dissolved in chloroform slowly.

Then we stir the mixture flask in an ice bath for two hours. 

NBMI will precipitate after we add about 100 mL of 0.1 mol L−1 HCl.

Later we collect and dry the powder to get what we need.

Irminix Dosages

It was designated as an orphan drug by the European Commission and USFDA in 2012. 

For now, it is still under processing by the pharmaceutical company EmeraMed Limited with the trade name Irminix.

Currently, the drug developing company can offer a 14-day treatment x 300mg per day of Irminix®. 

For more details, please check the web of EmeraMed Limited.

How Does Emeramide Work In Vivo?

Toxicity of mercury occurs at the intracellular level by binding of Hg2+ with thiol groups of relevant proteins.

It has been proved in animal models that mercury toxicity can be relieved by the use of BDTH2, which is able to cross the cell membrane and the blood-brain barriers to chelate Hg2+.

Also in clinical trial tests performed by Emeramed Limited, BDTH2  is proved to be a safe, effective way to detox mercury without the issues and side effects of other chelating agents.

In-vivo research (300mg per day) shows that it captures mercury and other heavy metals, which helps create free radicals and thereby restores normal functions to the mitochondria and overall health. 

There is no known toxicity shown by clinical research so far.

It has been sold as a nutritional supplement under the trade name OSR-1 for many years.

With the trade name of Irminix, it has already been approved by the European Medicines Agency.

What Is the HS Code Of Emeramide?

Emeramide is classified as an organic compound belonging to the class of Other organic sulfur compounds.

It has the HS code as 2930909099 in China Customs in 2021.

If you are looking to import its finished formulations, its HS code should be 30049092 or 3004900000.

Check with your customs broker before you import.

How Much Does Emeramide Cost?

The price Of NBMI not only depends on your order quantity but also is subject to upper-stream raw material price fluctuations.

If you need to buy a few grams for lab research, you can compare our prices with costs from other companies first.

For an order quantity of 100G~500G, the cost from octagonchem is around 20usd/G

For small orders of 10~20G, our price is about 30~50usd per gram.

Now please check costs from reagent companies below and you will find the best price you can get from reagent companies is 70usd/g for 5g.

Price from TRC-canada is 70usd/g for 5g

Price from medchemexpress is 180usd for 0.5g

Price from adooq is 60usd for 0.1g

Currently, the shipping cost is not stable either, shipping to UK and US will be covered by our side for orders over 500USD.

No matter which country you are from, UK or Canada, you can contact us directly for cost details.

Our Unique Selling Point

#1. High purity:

Our BDTH2 is 99% with a consistent manufacturing process.

#2. Fast shipment:

We keep a fresh stock of 200G~500G and an international tracking number by TNT/FedEx can be provided within 3~4 days.

#3. Quality assurance:

100% refund for any quality issues tested with 1HNMR and LC-MS.

#4. Low MOQ:

Our MOQ starts at 10grams and is subject to negotiation on smaller packings.

#5. Samples available for quality approval:

Samples for testing are available. (We may have to charge you sample fees as it is expensive)

#6. Commercial manufacturing status very promising and optimized:

we are ready to move to commercial-scale production from our current lab-pilot scale.

How To Ship and Store Emeramide Powder?

packing details for 50g emeramide powder
Packing Details For 50G

As a pure powder, it is white to almost-white crystal, with a characteristic acid smell.

When there is a color change or odor, test it for possible going-bad.

While it is a non-hazardous chemical to be shipped by air, courier, or by sea.

It is not a dangerous chemical, not toxic, not flammable or explosive, or oxidative.

It is actually very stable if you seal it and protect it from light, moisture, or heat.

For international shipping, we can ship it under room temperature, no need to ice it to keep it cool.

From the shipping experiences of the past 2 years, it is stable after shipment at normal temperature, with no obvious impurities found by HPLC after our customers got it.

While after you receive the package, it is highly recommended to be stored under -20 degrees celsius for long-term storage.

For short-term storage of several days or weeks, 2~8 degrees celsius will be just fine.

Just make sure it is air-tight and protected from light and heat.

Technical Documents Download

References

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