99% Bumetanide From GMP Manufacturer In China
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Why You Should Buy Bumetanide Powder From Us?
#1. High purity with the single impurity below 0.1%:
HPLC purity is 99% as min and it meets the requirements of EP9.0 Standards.
All its single impurities are controlled below 0.1% and total impurities are less than 0.2%.
#2. The most beautiful color:
Due to our high purity and fine crystal form, the bulk powder is a pure white powder, not off-white stuff.
#3. Steady supply with the fast shipment:
We have 1kilo in stock and you can get the tracking number within 3~4 days after your order.
What is Bumetanide?
Cas Number: 28395-03-1
Molecular Weight: 364.42 g/mol
Molecular Formula: C17H20N2O5S
Chemical Name: 3-(Butylamino)-4-phenoxy-5-sulfamoylbenzoic acid
HS Code: 2916399090 (其他芳香酸-Other aromatic monocarboxylic acids)
Bumetanide is a white or almost white crystalline powder.
It is insoluble in water but soluble in ethanol and acetone, slightly soluble in methylene chloride.
Meanwhile, it will dissolve in dilute alkali solutions.
What is Bumetanide Used For?
Bumetanide is used to treat edema in heart failure, liver disease, and kidney disease.
It is mainly used for all kinds of intractable edema and acute pulmonary edema.
It is especially suitable for patients with acute and chronic renal failure.
After oral administration, 95% is rapidly absorbed by the gastrointestinal tract with 95% of bioavailability and protein binding rate.
The diuretic effect appears within 30 min after oral dosing, but it will work in 5 min after intravenous injection, peaks in 30 min, and is maintained for 2-3 h.
About 45% of the oral dose is excreted in its original form.
The elimination half-life is 1~1.5h, slightly longer in patients with renal failure.
Its mechanism of diuretic action is mainly through the inhibition of Na-K-ATPase activity.
It works by the inhibition of the active reabsorption of Cl- and the passive reabsorption of Na in the ascending crude segment of medullary collaterals, which affects the concentration and dilution process of urine.
Bumetanide will also act on the proximal tubule and has some renal vasodilatory effect.
Cl- excretion increases 20-fold and Na+ excretion increases 13-fold at the beginning of diuresis
The inhibition of carbonic anhydrase by bumetanide is weaker than that of furosemide, so its potassium loss is also lighter than that of furosemide.
Bumetanide 1mg equals about 40mg of furosemide.