Buy 99% Alpha-Estradiol API Of GMP Factory

Why Purchase Alpha-estradiol From Us?

#1. High Purity with ready stock:

With our optimized lab-synthesis route, the purity of our alphaestradiol is over 99% tested by HPLC.

Plus, it is in stock and ready for shipping, so we can ship it out by FedEx within 2~3 Days.

#2. Low MOQ with the best prices you can find within China:

Though the total demand for alfa-estradiol is not big every year, we manufacture 1~2 batches each year, by 1~2 KG each time, but we are willing to repack it into 1G/5G/10G/25G/100G/500G to meet the needs of our customers.

#3. The whole set of testing spectra is available:

If you need to make sure that you are buying estradiol of its alpha-type, rather than the beta-type, then you better check all the testing spectra for your confirmation before ordering.

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What Is Alpha-estradiol (Alfatradiol/17α-Estradiol)?

Alpha-estradiol 57-91-0 chemical structure

Cas number: 57-91-0

Molecular formula: C18H24O2

Molecular weight: 272.388 g/mol

Melting Point: 222~226 Degrees Celsius

Boiling Point: 445.9±45.0 Degrees Celsius

Specific optical rotation{[a]20/D(c=1 in Dioxane}: 46~52

Chemical Name: (8R,9S,13S,14S,17R)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol

HS Code: 2937239090(Other estrogens and progestins-其他雌激素及孕激素)

Alpha-estradiol, also known as 17α-Estradiol, or alphaestradiol, or alfatradiol, is the stereoisomer of estradiol(Beta-Estradiol)

It is a white to off-white powder soluble in organic solvents, such as DMF, DMSO, and ethanol.

Alpha-Estradiol VS Beta-Estradiol

There are two types of isomers of estradiol in the market, the alpha type, and beta type, and yes, they are enantiomers.

Since alpha type is more expensive with a more difficult synthesis process, the point is: how can you be sure you are buying the right molecule?

Since the alpha and beta-type are isomers, they are like twins and, if you are not an expert on them, it is not easy to tell the differences by counting the number of hydrogens through 1HNMR.

But as one of the leading estradiol experts in China, we have listed the analysis methods you can use to run the tests:

#1. Specific optical rotations:

The easiest way to tell if the molecule is alpha-type or not should be the test of optical rotation.

Get a solution of 10mg per mL in dioxane and calculate its specific rotations.

The rotation of the alpha-type is about +51~+56 degrees, but the beta-type is +76~+83 degrees.

#2. Melting Range:

By their melting-point test, you can also tell which is which.

The melting range of alphaestradiol is 223~229 degrees celsius, while the melting range of beta-type is 76~83 degrees. So you know it is easier to melt the beta-type.

#3. HPLC/1HNMR against Reference Substances:

HPLC and 1HNMR are commonly used as the identification methods for many molecules.

In this case, you will need the reference substances to do the comparison.

The downside of Reference substances is that they are super expensive.

Combing the testing results of melting range and specific rotation, now all you need to do is to test it by 1HNMR.

If the chemical structure is correct and the testing results of the specific rotation/melting range correspond to the data above, you are buying the alpha-type indeed.

How Much Does Bulk Alpha-estradiol Cost?

#1. Reference Substances or Working Standards:

If you are looking for the very pure powders as your Reference Substances for HPLC testings, etc, we don’t have 99.99% pure powders for sale.

For this purity, you may need to check reagent companies for details.

But the price can’t be cheap, as we don’t see any suppliers for it.

If you have to have 99.99% or purer powder, you can try purifying powders of 99% type, then you may get what you need.

#2. Common 99% Powders Used for Research

For 99% type powder, please check our prices as below:

1G: 150usd excluding shipping cost.

5G: 80usd/G without shipping cost.

10G: 50usd/G including the shipping cost.

100G: 30usd/G including the shipping cost.

For orders over kilos, please contact us directly for more details.

How Will Your Alpha-estradiol API Be Shipped?

#1. Lead time:

For orders of 1kilo or less, repacking will be arranged within 2 days after your order confirmation.

Once the sample is repacked, it is ready to be shipped out.

For orders of over 5kilo, you might want to confirm the lead time before placing the order with us.

A good shipping schedule will avoid troubles for your supply chain.

#2. Shipping methods

About the ways of shipping, there are 2 main options left due to its small quantity.

It will either be shipped by FedEx or by airplane.

FedEx is willing to ship it because it is a safe or common chemical to be shipped by air.

#3. Packing and labeling

For orders of kilos, this product can be packed into bags or bottles.

The buyers will decide on the packing, no extra charges for bottles though.

Some buyers may worry about the possible breakages of glass bottles, but that is not going to happen to our HDPE or fluorinated bottles, which are firm and steady.

Then it is the labeling: buyers can send us the label format before the shipping.

Our default label will be standard labeling with PRODUCT NAME, NET WT., BATCH NO., MFG DATE, EXP DATE, MADE-IN-CHINA, etc., along with our company name and logo.

If you need a neutral label without our company name, please inform us in your PO.

#4. Customs Clearance and Customs Fees

As chemicals are complicated issues in every Customs, all buyers should at least consult their import brokers before any import of chemicals.

Or the Customs clearance will be an overwhelming nightmare: your goods can be stuck in the Customs for months of inspections.

Normally FedEx will help you with the Clearance, to submit TSCA or other papers required by Customs Authorities, but they can’t do all the things.

You need to know what you are doing.

Though we have DDU or DDP terms for certain countries, these services are not suitable for small orders.

Contact us directly if you need these services and we will check them for you.

Why Is Alpha-estradiol Used For Hair-loss?

Although 17alpha-estradiol is the weaker version of estradiol compared to 17-beta-estradiol, about 100-fold less estrogenic, it works wonders on hair loss treatment.

17-α-estradiol can effectively inhibit 5α-reductase, which plays an important role in regulating hair growth.

There are plenty of YouTube videos showing the comparison between before and after, their hair growth conditions after using minoxidil and alfaestradiol.

it turns out that many people have grown back many hairs with alfatradiol after ditching minoxidil when it is not working.

However, studies are showing that 5% minoxidil is still the most effective remedy for hair loss so far.

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