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minoxidil chemical structure

Minoxidil 38304-91-5 Structure

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Standards: USP/EP/CP

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MOQ: 1 standard Packing (Subject To Negotiation)

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What is minoxidil (Rogaine)?

Minoxidil, with Cas Number as 38304-91-5 and chemical name as 2,4-Diamino-6-piperidinopyrimidine 3-oxide or 6-Piperidin-1-ylpyrimidine-2,4-diamine 3-oxide, was originally used as a potent direct-acting peripheral vasodilator to lower blood pressure, but it showed a side effect of increased body hair. Later minoxidil is widely studied and used to treat hair loss. Studies had shown that about 40% of men experience hair regrowth after 3–6 months. Minoxidil must be used indefinitely for the continued support of existing hair follicles and the maintenance of any experienced hair regrowth.

Minoxidil is used with many other ingredients to achieve better hair-growing effects. People combine minoxidil with finasteride, dutasteride, azelaic acid, tretinin for many hair-growing products. Studies show that 0.01% Tretinin is able to double the Minoxidil efficacy.

The most well-known brand in the market for hair loss is Rogaine by Johnson & Johnson. North America is the leading global minoxidil market owing to the high adoption of hair-loss treatment products. According to the American Hair Loss Association, over 80% of men experience hair loss by the age of 50. Further, over 21 million women suffer from hair loss problems and about 40% of them opt for active treatments. The demand for minoxidil is expected to surge due to the aging global population. According to the United Nations Economic & Social Commission for Asia and the Pacific (ESCAP) in North & Central Asia, the population ratio aged 60 and above will increase to over 24% by 2050.

Minoxidil 2% VS Minoxidil 5%

There are two common specifications of Minoxidil topical formulations in the market: 2% type and 5% type, either as topical solutions or aerosol foams or the topical liquids. But which specification and form do we choose for better hair growth for different people?

According to one study conducted by Duke Dermatopharmacology Study Center in 2002, it showed that In men with AGA (Androgenetic Alopecia), 5% topical minoxidil was superior to 2% topical minoxidil and placebo in increasing hair regrowth, and the magnitude of its effect was marked (45% more hair regrowth than 2% topical minoxidil at week 48). Men who used 5% topical minoxidil also had an earlier response to treatment than those who used 2% topical minoxidil. Psychosocial perceptions of hair loss in men with AGA were also improved. Topical minoxidil (5% and 2%) was well tolerated by the men in this trial without evidence of systemic effects.

2% minoxidil topical solution was approved for the first time in 1991 to treat women’s hair loss by Upjohn, applied twice daily. In more recent years, The first 5% minoxidil foam for women was approved in 2014, applied once daily. 5% minoxidil foam no doubt costs less time and is more convenient to apply. There was a study conducted showing that patients using 5% foam had a mean 32-hair/cm2 or 16% increase, not significantly different from the 14% increase documented in women on the 2% topical solution, but 2% is better than nothing right? Polls are showing that women prefer 5% minoxidil foam to 2% minoxidil topical solution.

By comparison, we conclude that minoxidil 5% works better than 2% for hair growth and 5% Minoxidil solution was found to be more effective than 2% in maintaining existing hair and regrowing lost hair. 

In general, it has been found that the higher the concentration of Minoxidil the better the effect in terms of treating androgenetic alopecia. However, the higher concentration, more increased risk of adverse side-effects. We can already see 10% even 15% minoxidil formulations in the market. Please be cautious and consult your doctor before choosing your Minoxidil specifications.

Is There Minoxidil For Beard Growth?

Partially influenced beard-star James Harden from Houston Rockets of NBA, to grow a thick beard is getting more and more popular.

Are there any finished topical formulations of minoxidil in the market for growing a thick beard? The ‘official’ answer is NO, as there is no approved formulation in any FDA for beard growth.

But there are many successful cases of men applying minoxidil to their faces to get their thick beards. Actually, you can use any minoxidil topical formulations you can find in the market such as Rogaine, Kirkland, Equate, Tugain, and Lipogaine, etc

How Is Minoxidil Classified?

Minoxidil is an organic compound with a pyrimidine ring. 

It belongs to one group categorized as ‘Other compounds containing pyrimidine rings in the structure (including other compounds containing piperazine rings in the structure), with HS Code as 2933599090.

What Is 99% Minoxidil Price? (updated 2019.12.06)

There are two Grades of Minoxidil available: 

1. Pharmaceutical-grade Minoxidil available with GMP&DMF for drug manufacturing.
2. Cosmetic Grade Minoxidil and Minoxidil Sulphate for topical formulations.

The price for commercial order quantity (over 100kg) of pharma-grade minoxidil in China is around 350usd/kg, while the price of pharma-grade minoxidil from India is around 170usd/kg.

The price for commercial order quantities (over 100kg) of cosmetic-grade minoxidil is around 300usd/kg.

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