98% Vitamina K2 (MK-7) a granel de fábrica ISO
Vitamin K2 (MK-7)—also known as Menaquinona-7—is a highly bioactive, lipid-soluble form of vitamin K2 characterized by a seven-isoprene-unit side chain. This unique molecular structure gives it an exceptionally long half-life (up to 72 hours) in the human bloodstream compared to other vitamin K variants.
MK-7 is a homolog of Vitamin K2, primarily produced by bacteria and found in fermented foods such as natto. It is identified as the most bioactive cofactor in the carboxylation of Gla proteins. Human cells cannot produce MK-7 endogenously, making exogenous sources—including dietary supplements and functional foods—essential. This is why Vitamin K2 is often called the “platinum vitamin”.
¿Por qué elegirnos como su proveedor de vitamina K2?
1. Pharmaceutical-Grade Purity
We deliver Vitamin K2 (MK-7) API with ≥98.0% purity (HPLC-verified), y≥99.0% purity is available for premium pharmaceutical formulations. Every batch undergoes rigorous quality control testing for identity, purity, and impurity profile. We maintain complete documentation of pharmacopeial and non-pharmacopeial impurities—a critical requirement for regulatory submissions.
2. Controlled Microbial Fermentation
Our Vitamin K2 (MK-7) API is produced via controlled microbial fermentation—the preferred method for producing naturally occurring, all-trans MK-7. This advanced biotechnological approach ensures:
Natural, all-trans configuration—the biologically active form
Exceptional purity and potency
Elimination of unwanted impurities
Batch-to-batch consistency—rigorous quality control at every stage
Full traceability—from fermentation to finished API
3. GMP-Certified Manufacturing with Full Regulatory Support
Our manufacturing facilities operate under strict cGMP conditions con Certificación ISO. We provide comprehensive documentation for regulatory submissions:
Archivo Maestro de Medicamentos (DMF) access letters for ANDA filings
Certificado de Idoneidad (CEP) for European market access
Certificado de análisis (CoA) per ICH guidelines
Method of Analysis (MOA) documentation
Hoja de datos de seguridad del material (MSDS) in GHS format
Datos de estabilidad—accelerated and long-term
Complete impurity profile documentation
Certificación GMP from recognized regulatory authorities
ISO, FSSC, HALAL, and KOSHER certifications available
4. Supply Chain Reliability at Scale
Scalable capacity—From gram-level samples to multi-ton commercial orders
Global logistics—Seamless shipping to the US, EU, Asia-Pacific, and beyond
Flexible packaging—1 kg/aluminum foil bag, 5 kg/carton, 25 kg/drum (customizable)
Cold chain capability—Protected from light, -20°C storage, argon charged
Large inventory—Maintained year-round to ensure rapid fulfillment
Rapid delivery—Samples shipped within 24 hours; bulk orders arranged within 72 hours
Competitive pricing—Cost advantages without compromising quality
5. Technical Partnership for Formulation Success
The Vitamin K2 (MK-7) market is expanding at a remarkable 8–15% CAGR. Success requires a partner who delivers more than just raw material. We help you win by providing:
Formulation optimization support for softgels, capsules, tablets, gummies, and beverages
Regulatory guidance for FDA GRAS, novel food, and global submissions
Desarrollo de métodos analíticos support—including cis/trans purity assessment
Custom concentrations—0.2%, 1%, 2%, and higher on appropriate carriers
Expert technical support from formulation scientists
Dedicated account management with rapid response
6. Compounding Pharmacy and Research Solutions
Small-order flexibility—Custom quantities for compounding and R&D applications
Purity you can trust—High-grade ingredients minimize cross-contamination risks
Technical guidance—Expert advice on storage, processing, and formulation
Reference standard availability—For analytical method development and quality control
Vitamin K2 Bulk Powder Applications and Specifications
Descargar documentos del fabricante
By activating both MGP and Osteocalcin, MK-7 functions as a physiological “traffic director,” forcefully directing calcium away from delicate arterial walls and safely routing it into the bone matrix—preventing cardiovascular morbidity while simultaneously combating renal osteodystrophy.
Dietary Supplements (Largest and Fastest-Growing Segment)
Vitamin K2 (MK-7) is one of the most widely used ingredients in dietary supplements targeting bone health, cardiovascular health, and healthy aging. Key applications include:
Bone health supplements—supporting bone mineral density and reducing fracture risk
Cardiovascular health formulations—preventing arterial calcification
Calcium metabolism support—directing calcium to bones rather than soft tissues
Productos combinados—with Vitamin D3 for synergistic bone and cardiovascular support
Anti-aging and longevity formulations
Typical Supplement Dosage:
Standard daily dose: 90–180 µg (mcg)
Typical range: 45–360 µg/day
Optimal timing: Take with a meal containing fats for optimal absorption
Common forms: Softgels, capsules, tablets, and gummies
Pharmaceutical Applications (High-Growth Segment)
MK-7 is increasingly recognized for its therapeutic potential:
Nephrology—preventing vascular calcification in CKD and ESRD patients
Cardiology—reducing coronary artery calcification progression
Osteology—supporting bone health in osteoporotic patients
Metabolic health—supporting insulin sensitivity and glucose metabolism
Calcific aortic valve stenosis (CAVS) —activating matrix Gla protein to intervene in disease progression
Functional Foods and Beverages
MK-7 is increasingly incorporated into:
Nutritional beverages—FDA GRAS status permits use in nutritional beverages
Dairy products—following GRAS approval
Nutritional and cereal bars
Fortified foods
Cosmetics and Personal Care
MK-7’s antioxidant and skin-protective properties make it a valuable ingredient in:
Anti-aging skincare formulations
Protective formulations—defending against oxidative damage
Nombre del producto: Vitamina K2 (Menaquinona-7, MK7)-K2 de la serie de televisión
Apariencia:Un polvo amarillo
Solubilidad: Insoluble en agua
Número CAS: 2124-57-4
Fórmula molecular:C46H64O2
Peso molecular:649 g/mol
Nombre químico: 2-[(2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptametiloctacosa-2,6,10,14,18,22,26-heptaenil]-3-metilnaftaleno-1,4-diona
Código HS:2936290000 (其他未混合的维生素及其衍生物-Las demás vitaminas sin mezclar y sus derivados)
Aptitud para ser enviados por vía aérea como mercancías comunes: Adecuado. Se puede enviar por vía aérea sin ningún problema, como si fuera una mercancía común.
Calificación: Grado alimenticio
Pureza o Ensayo: 98%
Normas:Estándares empresariales actuales
Certificados del fabricante disponibles:ISO/Kosher/Halal
Documentos del fabricante disponibles: Certificado de autenticidad/ficha de datos de seguridad
Capacidad de suministro:10 kg por mes
Cantidad mínima de pedido:1G
Ideas de precios en 2024:350 USD/1G por 1G, 200 USD/G por 1kg (Contáctanos por WhatsApp para precios más actualizados)
Plazo de entrega:3~4 días para cantidades inferiores a 500G, 2~3 días para pedidos inferiores a 10G.
Estado del stock:Más de 1000 G
Temperatura de envío:Temperatura ambiente
Almacenamiento:2~8 °C
FAQs About Our MK7 Powder In Bulk
What purity level do you guarantee for Vitamin K2 (MK-7) API?
We guarantee ≥98.0% purity (HPLC-verified) for pharmaceutical-grade, with ≥99.0% purity available for premium formulations. Every batch is tested for identity, purity, and quality parameters in accordance with USP standards.
What documentation do you provide with each order?
Every shipment includes a Certificate of Analysis (CoA), Method of Analysis (MOA), Material Safety Data Sheet (MSDS), and stability data.
¿Cuál es su cantidad mínima de pedido (MOQ)?
For commercial manufacturers, our MOQ is 1 kilogramo, with volume discounts available for larger commercial orders. For R&D, analytical research, and compounding pharmacy applications, we offer smaller quantities.
Is your Vitamin K2 (MK-7) API GMP-certified?
Yes. Our API is produced in facilities adhering to strict Buenas Prácticas de Manufactura actuales (cGMP) for pharmaceutical and nutraceutical ingredients, with full compliance with ICH Q7 guidelines. We maintain DMF filings with regulatory authorities.
What is the mechanism of action of Vitamin K2 (MK-7)?
MK-7 acts as an essential cofactor for the enzyme gamma-glutamyl carboxylase. It activates two key proteins through carboxylation: Matrix Gla Protein (MGP) in the vasculature—the most potent known inhibitor of vascular calcification—and Osteocalcin in bone tissue. This dual mechanism directs calcium away from arterial walls and into the bone matrix, preventing cardiovascular morbidity while supporting bone health.
What is the half-life of Vitamin K2 (MK-7)?
MK-7 has an exceptionally long half-life (up to 72 hours) in the human bloodstream compared to other vitamin K variants. This extended half-life enables once-daily dosing and sustained biological activity.
What is the difference between Vitamin K2 as MK-7 and MK-4?
MK-7 and MK-4 are both forms of vitamin K2, but they differ significantly:
MK-7 tiene un seven-isoprene unit side chain, giving it a longer half-life (up to 72 hours) y superior bioavailability compared to MK-4
MK-7 es el most bioactive form of vitamin K2
MK-7 es produced via bacterial fermentation and found in natto
MK-7 is the preferred form in modern nutraceutical and pharmaceutical formulations
What is the solubility and storage profile of Vitamin K2 (MK-7) API?
Vitamin K2 (MK-7) API is a light yellow to yellow crystalline solid that is lipid-soluble and practically insoluble in water. It should be stored protegido de la luz, en -20°C, under argon. Shipping requires a cold chain (ice chest + ice pads).
Is Vitamin K2 (MK-7) FDA-approved?
Vitamin K2 (MK-7) is FDA-approved under Generally Recognized As Safe (GRAS) status as a dietary supplement. The FDA has issued a “No Question” GRAS Notification for Natural Vitamin K2 (MK-7). It is permitted for use in nutritional beverages in the United States. It is also permitted as a source of Vitamin K in the European Union.
Who are the primary manufacturers of Vitamin K2 (MK-7) API?
Key manufacturers include Kappa Bioscience AS (Norway—K2VITAL®), NattoPharma (Norway—MenaQ7®), DSM (Global), Synergia Life Sciences (India—MenaquinGold®), GF FERMENTECH (MediQ7®), and numerous manufacturers in China,na including Seebio Biotech y Richerpharm Technology.
What are the common side effects of Vitamin K2 (MK-7)?
Vitamin K2 (MK-7) is generally well-tolerated with no known toxicity at recommended doses. Es non-toxic and safe for long-term use. Patients taking coumarin anticoagulants (such as warfarin) should no take Vitamin K2 supplements without medical supervision.
What drug interactions should be considered?
Vitamin K2 (MK-7) is not suitable when taken simultaneously with coumarin anticoagulants. Patients should inform their healthcare provider about all medications they are taking, particularly blood thinners.
Can you supply Vitamin K2 (MK-7) API for compounding pharmacy applications?
Yes. We supply Vitamin K2 (MK-7) API in quantities suitable for compounding pharmacies. Our API can be used to formulate patient-specific doses and alternative dosage forms.
Otros ingredientes nutricionales que podría necesitar
