99% SBECD de fábrica con certificación cGMP en China
Betadex Sulfobutyl Ether Sodium—also known as SBECD, Sulfobutylether-β-cyclodextrin, y Captisol®—is the active excipient behind some of the most innovative injectable and parenteral drug formulations in modern medicine. As a highly water-soluble, anionic derivative of β-cyclodextrin produced by introducing sulfobutyl ether groups, SBECD has emerged as the preferred solubilizing excipient for parenteral drug delivery, with an unparalleled record of safety, efficacy, and regulatory acceptance.
SBECD is available in multiple grades:
Injectable Grade — for parenteral formulations, with strict endotoxin control (≤20 EU/g)
Pharmaceutical Grade (Oral) — for tablets, capsules, and oral liquids
Nutraceutical Grade — for dietary supplements and functional foods
Grado cosmético — for skincare and personal care formulations
Research Grade — for analytical and preclinical applications
¿Por qué debería importar SBECD de nosotros?
#1. Alta calidad:
We guarantee the quality of our SBECD through consistent manufacturing processes and strict quality control: we manufacture our Betadex Sulfobutyl Ether Sodium powder in a GMP-compliant factory. Our steady and innovative manufacturing process yields high-quality powder.
#2. Cantidad mínima de pedido (MOQ) baja:
Disponemos de paquetes de 100g y 200g para sus pedidos de prueba.
#3. Muestras disponibles para análisis:
Si no está seguro de nuestra calidad y desea probar nuestras muestras antes de realizar un pedido formal, podemos gestionar su envío. Contáctenos directamente.
¿Qué es Betadex Sulfobutil Éter Sodio (SBECD)?
Nombre: SBECD
Número CAS: 182410-00-0
Fórmula molecular: NA
Peso molecular: 2242,0461 g/mol
Código HS: 3505100000 (Dextrinas y otros almidones modificados-糊精及其他改性淀粉)
Otros nombres: sal sódica de éter sulfobutil b-ciclodextrina, éter sulfobutil β-ciclodextrina, sal sódica de beta-ciclodextrina sulfobutilada, SBECD, sbebcd.
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Bulk Betadex sulfobutyl ether sodium Powder Es un polvo cristalino de color blanco a blanquecino.
Es uno de los más excipientes populares ever used in our pharmaceutical industry, especially for injections.
Es amorfo e higroscópico.
Es libremente soluble en agua y ligeramente soluble en metanol, pero insoluble en etanol, acetato de etilo y diclorometano.
Its solubility in 100ml water is more than 50g, the pH of its 30% water solution is 5.4~6.8.
Es una versión mejorada de hidroxi beta-ciclodextrina, with better complexation performance but at a higher price.
¿Para qué se utiliza el SBECD?
La sulfobutil-β-ciclodextrina es un derivado aniónico de ciclodextrina con mejor solubilidad en agua.
Formará un complejo no covalente con muchos API (insoluble en agua) para mejorar y optimizar las propiedades del API.
The SBECD & Heparin complex exhibits biological activity similar to heparin but with lower nephrotoxicity, so SBECD is widely used as a high-end injection carrier.
SBECD will make APIs more stable and more readily soluble in water for injection. It will also lower their renal toxicity and reduce their chances of hemolysis.
También utilizamos SBECD para controlar la tasa de liberación de ingredientes activos mientras cubrimos los olores y sabores amargos del API.
Los estudios han demostrado que aproximadamente el 40% de los nuevos API son insolubles en agua y casi el 60% tienen poca solubilidad en agua.
Due to their poor water solubility, clinical trials of new drugs are less effective than expected.
This poor water solubility has significantly slowed the approval of these new molecules as new drugs.
Therefore, many pharmaceutical manufacturers have widely used Sulfobutyl-β-cyclodextrin sodium to improve the solubility of poorly water-soluble APIs, thereby enabling many new drugs to be approved.
When we mix docetaxel with sulfobutyl-β-cyclodextrin sodium at a molar ratio of 1:12, the solubility of docetaxel in water increases by about 800-fold, enabling the development of docetaxel water injections.
When we tested the water solubility of the complexed compound between sodium calycetin (Another API) and sulfobutyl-β-cyclodextrin sodium, we increased its water solubility by about 76-fold.
After we mix Amiodarone (API name) with sulfobutyl-β-cyclodextrin sodium at a molar ratio of 1:2, we increase the solubility of the complex in water by 195-fold.In In In
2020, we had COVID-19; Remdesivir is formulated as an injection by combining betadex sulfobutyl ether sodium.
Aunque es un excelente vehículo de inyección, ninguna compañía farmacéutica debería abusar de él.
According to scientific research, the maximum daily dosing is 320 mg/kg.
¿Cómo enviar y almacenar el polvo SBECD?
For shipping SBECD, you can ship it by sea if you purchase it in commercial order quantities.
Podemos enviarle pequeñas cantidades mediante mensajería o por aire.
It is a very safe chemical suitable for air shipment. Its certificate of safe air transportation is available.
During the transport, you don’t need ice bags or cold-chain storage. It is stable at RT.
La sulfobutil-β-ciclodextrina debe almacenarse en un envase interior hermético y protegido de la luz.
Because it is hygroscopic and readily draws moisture from the air, water can compromise its quality if it is not sealed well.
Aunque es relativamente estable, guárdelo en un recipiente firme, protegido del calor y la luz.
You can store it at room temperature, ensuring there is no significant temperature fluctuation.
Tiene una vida útil de 2 años. Asegúrese de realizar pruebas antes de usarlo.
¿Cuánto cuesta SBECD?
If you need to buy its injection-grade pure powder in commercial order quantities to manufacture injections, our FOB Shanghai/Beijing price is around 350~500 USD/Kilo.
Si sólo necesitas kilos para pruebas piloto, nuestro precio ronda los 600 USD por kg.
Si necesita varios gramos para investigaciones y pruebas de laboratorio, le prometemos la mejor calidad a los precios más bajos.
In case you are not sure if you are getting a reasonable price from us, you can check some of our online prices below:
As you can see from the reagent company’s offers, the price per 0.5g is higher than the cost of one kilo from us, not to mention the per-gram prices.
If your lab doesn’t have sufficient budget, give us a chance—you won’t regret it.