What Is Trazodone Hydrochloride?

Trazodone Hydrochloride Introductions

What Is Trazodone Hydrochloride?
Trazodone Hydrochloride Chemical Structure

Trazodone Hydrochloride API is a white to off-white crystalline powder sparingly soluble in water and chloroform.

It is the hydrochloride salt form of trazodone, a synthetic triazolopyridine derivative with antidepressant and sedative properties.

Based on studies from animal models, trazodone selectively inhibits the reuptake of serotonin by synaptosomes in the brain, thereby increasing serotonin levels in the synaptic cleft and potentiating serotonin activity.

Trazodone is not a monoamine oxidase inhibitor and, unlike amphetamine-type drugs, does not stimulate the central nervous system.

The sedative effect of trazodone is likely via alpha-adrenergic and mild histamine H1 blocking actions similar to Mirtazapine and Agomelatine.

What Is Trazodone HCl Used For?

trazodone hydrochloride is used for depression
Trazodone Hydrochloride is mainly used for depression

Trazodone hydrochloride is a medication that is primarily used to treat depression.

It is classified as a serotonin antagonist and reuptake inhibitor (SARI), which means it works by blocking the reuptake of serotonin, a neurotransmitter that plays a role in mood regulation, in the brain.

To avoid drug interactions, trazodone should not be used together with fluoxetine hydrochloride, which is also an antidepressant.

In addition to its use as an antidepressant, trazodone hydrochloride may also be used off-label to treat a variety of other conditions. These include:

1. Insomnia:

Trazodone may be used as a sleep aid due to its sedative effects.

2. Anxiety:

Some people find that trazodone can help reduce anxiety symptoms.

3. Chronic pain:

Trazodone may be prescribed as a pain management option for people with chronic pain conditions.

4. Opioid withdrawal:

Trazodone may be used as part of a treatment plan for people who are trying to stop taking opioids.

5. Agitation in people with dementia:

Trazodone may be used to calm agitated behavior in people with dementia.

It’s important to note that while trazodone hydrochloride can be effective in treating these conditions, it is not a first-line treatment and should only be used under the supervision of a healthcare provider.

Vets also prescribe trazodone in veterinary clinics for dogs and cats. While it is used for dogs, it helps them overcome separation anxiety. It is used to manage short-term anxieties in cats.

Anxiety dosage for dogs is around 2.5 mg per pound to 15 mg per pound per day.

How Much Does Trazodone HCl API Cost?

For pure Trazodone Hydrochloride API powder of USP41 standards, our price for 100g is around 300 USD.

For 1000g Trazadone HCL API powder for dogs and cats, our price is around 550 USD.

Of course, the prices are subject to fluctuations, and costs from batch to batch can be a lightly different.

Also if you have big orders, prices can be further negotiated.

For more detailed and updated prices, please contact us directly.


Leave a Comment

Your email address will not be published. Required fields are marked *

Scroll to Top