What Is Rapamyicn Used For?

Rapamycin chemical structure
Rapamycin Chemical Structure

Rapamycin, also known as sirolimus is a macrocyclic antibiotic with potent immunosuppressive activity used alone or combined with calcineurin inhibitors and corticosteroids to prevent cellular rejection after renal transplantation.

Rapamycin is a medication that belongs to a class of drugs known as immunosuppressants, such as Cyclosporin A, Tacrolimus,pimecrolimus, and mycophenolate mofetil.

Its therapy can be associated with mild serum enzyme elevations and it has been linked to rare instances of clinically apparent cholestatic liver injury.

Clinically rapamycin is also used to treat rare lung diseases as an antineoplastic.

However, its main use is to prevent the rejection of kidney transplants, indeed, it can also prevent the rejection of transplanted organs of livers, and hearts, in patients who have undergone organ transplant surgery.

rapamycin is used to prevent kidney transplant rejections
rapamycin is used to prevent kidney transplant rejections

It works by inhibiting T and B cells to get the patients through after the transplant surgery, it helps to suppress the immune system and reduce the risk of organ rejection.

It is typically used in combination with other immunosuppressant medications, such as corticosteroids (prednisolone, prednisone, dexamethasone, clobetasol propionate, and fluocinolone acetonide) and calcineurin inhibitors, to achieve the desired effect.

For example, rapamycin is used to treat intraocular inflammation by combining dexamethasone.

There is combined therapy of rapamycin as an mTOR inhibitor and prednisone for treating retroperitoneal fibrosis.

It may also be used off-label to treat certain autoimmune conditions, such as lupus and scleroderma, and certain types of cancer, such as lymphoma and breast cancer.

In these cases, it is believed to work by inhibiting the proliferation and activation of immune and cancer cells, respectively.

References

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