What Is Kojic Acid Dipalmitate?
Kojic acid palmitate, also known as KAD, is the palmitate ester of bulk Kojic acid.
KAD, derived from the natural product kojic acid found in certain types of fungi, is an improved version of kojic acid in many aspects.
Kojic acid dipalmitate is an off-white powder with excellent antioxidant properties and is also one of the most popular whitening agents, along with bulk alpha-arbutin, resveratrol, and L-glutathione reduced in bulk.
It is regarded as one of the most effective skin-whitening ingredients in the cosmetic industry.
What Is Kojic Acid Dipalmitate Used For?
Kojic acid dipalmitate is mainly used as a skin whitening agent to prevent the formation of melanin by inhibiting the activity of tyrosinase.
Let’s see what you can do with it for your skin.
#1. Skin-ligntening
Kojic acid dipalmitate is often added to skincare products to lighten the skin tone and enhance its overall appearance.
When used in skincare products, kojic acid dipalmitate can lighten dark spots, freckles, and other areas of hyperpigmentation.
One of the primary benefits of kojic acid dipalmitate in skin care products is that it is highly effective at brightening the skin. It works by inhibiting the production of melanin, the pigment that causes dark skin.
By limiting melanin production, kojic acid dipalmitate can brighten the skin and improve its overall appearance.
Studies have found that combining kojic acid palmitate with glucosamine derivatives exponentially increases its skin-whitening effect.
#2. Improving skin tone
In addition to its skin-lightening properties, kojic acid dipalmitate is known for improving the skin’s overall texture and tone.
When applied topically, kojic acid dipalmitate can help to smooth out rough and uneven patches of skin, making it an effective treatment for conditions such as acne scars and other forms of scarring.
#3. Increasing skin elasticity
It can also help improve the skin’s elasticity, making it look more youthful and radiant.
Kojic acid dipalmitate is also a powerful antioxidant, which means that it can protect the skin from damage caused by free radicals.
Free radicals are unstable molecules that can cause damage to cells in the body, leading to a variety of health problems, including premature aging and cancer.
By neutralizing these free radicals, kojic acid dipalmitate can help prevent skin damage and maintain skin health and radiance.
Kojic acid dipalmitate vs kojic acid, which is better?
Kojic acid palmitate is a derivative of kojic Acid, and it is regarded as the best kojic acid version in the kojic acid family so far.
From the above, you can see their structural differences.
Here we skip their differences in physical and chemical properties,s such as molecular weight, molecular formula, etc. We only list their differences as cosmetic raw materials:
#1 Different water solubilities: KAD<Kojic Acid
Kojic acid dipalmitate is a lipid-soluble substance insoluble in water or ethanol.
If you want to use it for whitening, you must choose oil-based lotions or serums, as they will not be dissolved and absorbed by your skin to achieve whitening effects.
While Kojic acid is insoluble in lipids, it is soluble in water.
Add kojic Acid to your water-based serums or lotions.
#2 Pigmentation and melasma-eliminating effects: KAD>Kojic Acid
Clinical trials have shown that the efficacy of kojic acid dipalmitate exceeds 50%, with a total effective rate of over 90%. However, the effect of kojic Acid alone is significantly lower.
#3 Whitening efficacy: KAD>Kojic Acid
Kojic acid ester has a more substantial inhibitory effect on melanin production than kojic Acid.
For example, kojic acid dibutyrate ester is twice as powerful in stopping melanin production as kojic acid
#4 Stability: KAD>Kojic Acid
As an ester, Kojic acid dipalmitate is more stable than kojic Acid.
Because there are two active hydroxyl groups in kojic Acid, kojic Acid is easier to oxidize, causing it to turn yellowish. In comparison, kojic acid dipalmitate is more stable to be oxidized to something else when these two hydroxy groups are protected. It is less likely for kojic acid palmitate to turn yellow or go bad when exposed to air, heat, light, and moisture.
Plus, kojic dipalmitate will not chelate with metal ions as kojic Acid does within your makeup, so kojic dipalmitate lotions will not easily change color or go bad compared to lotions containing kojic Acid.
Additionally, kojic Acid is unstable in alkaline environments due to its acidic nature, whereas kojic dipalmitate is relatively more stable when the environmental pH is between 3 and 10.
#5 Compatibility with other whitening ingredients: KAD>Kojic Acid
Kojic acid palmitate is compatible with most preservatives and sunscreens used in cosmetics.
It blends well with Vitamin C, alpha arbutin, and Vitamin C derivatives to achieve a more effective whitening effect.
Research has shown that the combined whitening effect of KAD increased exponentially.
#6 Safety: KAD>Kojic Acid
As an ester, kojic acid palmitate is neutral to your skin.
However, your skin may become itchy when exposed to a formula containing acids such as kojic Acid or glycolic Acid.
Research has shown that the Kojic acid solution is more likely to cause itching or irritation to your skin.
#7 Cost and Purity: KAC<Kojic acid
Despite the numerous advantages of dipalmitate over kojic Acid, kojic acid powder has its benefits.
Kojic Acid is less expensive, costing approximately one-ninth as much as dipalmitate powder.
Additionally, the purity of kojic acid powder is 99% minimum, and the purity of dipalmitate kojic Acid is 98% minimum.
To sum it up, KADhast has a significant advantage as a whitening agent over Kojic acid, except for its poor solubility in water and higher costs, as people often say: you get what you pay for”.
How Is Kojic Acid Dipalmitate Manufactured?
First, we obtain palmitoyl chloride by reacting PC13 with palmitic acid.
Then we let palmitoyl chloride react with kojic acid to obtain the crude product, and then wash and recrystallize it to obtain pure kojic acid dipalmitate crystals
(1) Synthesis of palmitoyl chloride
Add palmitic acid to a three-neck flask, and dissolve it in CC14. Slowly drop PC13 into the flask through a funnel.
We start the reaction at a low stirring speed.
Later, when the reaction begins, we let them react at 54~55 degrees Celsius for several hours.
Later, we heat it to 60 degrees and let the reaction continue for another hour. Then, we stop the reaction and remove H3PO3.
(2) Synthesis of kojic acid dipalmitate
First, dissolve kojic acid in an acetone/pyridine solution in a three-neck flask. Then slowly drip palmitoyl chloride through a funnel and allow the reaction to proceed at room temperature.
At the end of the reaction, we wash the target solid with cold water 3 times and filter it through a Büchner funnel.
Finally, we recrystallize and dry it under vacuum to obtain white, flaky crystals.
Results and conclusion:
(2.1) Water-free reaction conditions
PCl3 is a pungent-smelling liquid that will decompose to produce white smoke when exposed to water.
The yellow by-product in the flask during the reaction is phosphoric acid.
Due to the reactivity of palmitoyl chloride and PCl3, the entire experimental procedure must be carried out under anhydrous conditions.
(2.2) Different molecular ratios.
When the molar ratio of n(palmitic acid)/n (PCl3) is 1:2, the reaction has the highest conversion rate, and the purity of palmitoyl chloride is estimated to be 95% as a minimum.
(2.3) The reaction temperature.
When the reaction temperature is below 55 degrees Celsius, the chlorination reaction cannot be carried out effectively. However, when the temperature exceeds 55 degrees and the final reaction temperature reaches 60 degrees, the chlorination reaction is typically complete.
Thus, a suitable reaction temperature for preparing palmitoyl chloride is 55-60°C, and the final reaction temperature must be raised to 60°C and maintained for 1 hour to achieve the highest yield.
How To Mix Kojic Acid Dipalmitate With Your Makeups?
If you already have KAD in your possession, you will need to know how to incorporate it into your cosmetics, such as lotions, creams, serums, and sunscreens.
However, you must add it correctly, using a recommended concentration of 1-5% for external use only.
It can be mixed with:
Sunscreens and after-sun products
Makeup products
Skin-lightening products
Anti-aging products
Creams and lotions
And before you begin to blend it in, you need to know the base of your cosmetics: whether they are water-based or oil-based.
#1 Water-Based Cosmetics
As kojic acid dipalmitate is insoluble in water, it is difficult for you to mix it directly in water-based cosmetics.
Even when you manage to blend some in water-based solutions, it is easy for it to form crystal precipitates afterward.
To solve this crystallization problem, you can add isopropyl palmitate or isopropyl myristate to the oil phase containing kojic acid dipalmitate, heat the oil phase to 8 °C, and keep it warm for 5 minutes until the kojic acid dipalmitate is completely dissolved.
Then add the oil phase to the water phase and emulsify for about 10 minutes.
The pH value of the end products obtained typically ranges from 5.0 to 8.0.
The recommended dose of kojic acid dipalmitate in cosmetics is 3-5%. 1%~2% type is not fast-acting enough.
#2. Oil-Based Cosmetics
For oil-based products, it is easier to blend KAD in, as KAD is soluble in oil and insoluble in water.
Take an oil-based cream, for example: you can mix your kojic acid dipalmitate powder directly into it to make a 3~5% whitening cream.
Take 3~5g of pure kojic acid dipalmitate powder and mix it into a 100 ml cream by stirring and shaking until fully dissolved.
You can also dissolve it in white oil first before mixing the blended oil into a cream formulation.
What Is The Hs Code For Kojic Acid Dipalmitate?
Kojic acid dipalmitate is an organic ester.
It belongs to a group of heterocyclic compounds containing only oxygen as a heteroatom, with an HS Code of 2932999099.
Other Customs Ports are categorizing it as 2936210000 or 2915709000. Regardless, please confirm the HS code details with your import brokers before proceeding with customs clearance.
It is advisable to verify the import taxes and duties with your Customs Hotline if you don’t have an import broker.
How Much Does Kojic Acid Dipalmitate Cost?
Prices in 2020 have risen by almost 10% compared to 2019.
For a 100g sample to start, our price is $ 100.
If you order only 1 kg as a trial order, our total cost, including shipping, is 2$280-$330USD, depending on your location
For small order quantities of 25 kg, our price is approximately 120 USD/kg, including express shipping costs.
For commercial order quantities of 1,000 kg or more, our FOB Shanghai price is approximately $ 40/kg.
If you are interested in obtaining an estimate of landed cost, we would be glad to provide one.
For more accurate pricing, please get in touch with us directly.
How To Ship and Store Kojic Acid Dipalmitate?
#1. Shipping methods:
As a pure powder, kojic acid dipalmitate is a safe and common chemical that can be shipped by air.
Chinese testing authorities have categorized them as familiar and safe goods, allowing us to ship them freely by air or express/courier for small order quantities or urgent orders.
Due to its high stability, there is no need to put an ice pad in the box to keep it cool during shipping.
For large order quantities, shipping by sea is also a safe and suitable option, as it is the most economical method.
#2. Storage conditions:
For storage, it is best to place it in a well-ventilated room with a stable temperature. Please note that the storage temperature must not exceed 25 Degrees Celsius.
Please protect it from sunlight and moisture. The shelf life is at least 24 months when stored properly. properly
Disclaimer:
This content is for informational purposes only and is intended for business-to-business communication within the pharmaceutical industry. It is not intended as medical advice. The manufacture, import, and use of API must comply with all applicable laws and regulations in the relevant country or region.
This blog post is informational only and does not constitute medical advice.
Always consult a healthcare professional before starting any new medication or treatment.
