What is Bumetanide API Used For?

bumetanide 28395-03-1 chemical structure
Bumetanide API Chemical Structure

Bumetanide API Appications

Bumetanide API is used to treat edema in heart failure, liver disease, and kidney disease.

It is mainly used for all kinds of intractable edema and acute pulmonary edema.

It is especially suitable for patients with acute and chronic renal failure.

After oral administration, 95% is rapidly absorbed by the gastrointestinal tract with 95% bioavailability and protein binding rate.

The diuretic effect appears within 30 min after oral dosing, but it will work in 5 min after intravenous injection, peaks in 30 min, and is maintained for 2-3 hours.

About 45% of the oral dose is excreted in its original form.

The elimination half-life is 1~1.5h, slightly longer in patients with renal failure.

Its mechanism of diuretic action is mainly through the inhibition of Na-K-ATPase activity.

It works by inhibiting the active reabsorption of Cl- and the passive reabsorption of Na in the ascending crude segment of medullary collaterals, which affects the concentration and dilution process of urine.

Bumetanide will also act on the proximal tubule and has some renal vasodilatory effect.

Cl- excretion increases 20-fold and Na+ excretion increases 13-fold at the beginning of diuresis

Bumetanide’s inhibition of carbonic anhydrase is weaker than that of furosemide, so its potassium loss is also lighter than that of furosemide.

Bumetanide 1mg equals about 40mg of furosemide.

How To Ship Bumetanide API?

Bumetanide is not a cheap API, so the order quantity won’t be very big.

That only leaves us the shipping options by courier or by air.

But we mainly choose couriers and we will break it into details below.

First things first, bumetanide is a safe chemical to be shipped by air or couriers, it is proven to be a common chemical by DGM and other testing facilities.

So you won’t have to pay such sky-high shipping costs as you do with dangerous chemicals.

Shipping by courier requires careful planning and attention to detail to ensure that the powder is handled and transported safely.

When shipping it by courier, it is important to have the correct packaging materials. We will make sure that the container is leak-proof, moisture-proof, and properly labeled, and it should withstand the pressure and temperature changes that may occur during transportation. 

Meanwhile, we also use a suitable filler material, such as a thick foam or a gel, to fill any gaps or spaces in the container to prevent the powder from leaking or spilling.

In addition to having the correct packaging materials, the key to import clearance is that the importers should also follow the appropriate shipping regulations for bumetanide. If this chemical is subject to certain regulations, you should check with the relevant agencies, such as the U.S. Food and Drug Administration (FDA) and the U.S. Department of Transportation (DOT), to ensure that you are complying with all relevant regulations.

To ship it by courier, we will choose FedEx/TNT/DHL which has experience handling sensitive or hazardous materials. They will provide tracking information and regular updates on the status of your shipment, so you can monitor its progress and ensure that it arrives safely and on time.

When preparing our shipment for courier pick-up, we will provide detailed instructions for handling and storage on the packaging, as well as any special handling instructions, such as the need to avoid inhaling the powder. We will also ensure that the package is properly sealed and labeled and that it is ready for pickup to avoid any delay.

By following these steps, we can ensure that your shipment of bumetanide powder is handled and transported safely by courier.

If you insist on shipping it by air, it is pretty much the same process.

References

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