What Is Bacitracin Zinc?

bacitracin zinc structure
Bacitracin Zinc Chemical Structure

Bacitracin zinc is an effective narrow-spectrum antibiotic peptide with a similar antibacterial spectrum to penicillin, mainly for Gram-positive cocci and bacilli.

It is a white or off-white powder with a characteristic odor and bitter taste, a mixture of related cyclic peptides produced by organisms of the licheniformis group of Bacillus subtilis var Tracy.

These peptides disrupt Gram-positive bacteria by interfering with the cell wall and peptidoglycan synthesis.

Zinc bacitracin is one of our USFDA-Approved pharmaceutical ingredients along with Bacitracin Powder and polymyxin b sulfate Powder.

Those 3 ingredients are often mixed to be produced into ointments, sprays, etc, to avoid infections of the small cuts.

Bacitracin zinc also exerts a certain inhibitory effect on several Gram-negative bacteria, spirochetes, and actinomycetes with high efficiency, low toxicity, and low residue.

First thing first, we must mention upfront, there are two types of powders:

1. high-potency type Pharm-Grade (Potency No Less Than 65IU/MG);

2. Feed-Grade or Industrial-Grade (Potency Less than 40IU/MG, often made into premixes).

Here we only supply pharmaceutical-grade types which are used to manufacture medicines for humans.

How Is Bacitracin Zinc Powder Produced?

#1. Fermentation

Fermentation process using Bacillus subtilis and B. licheniformis to get Bacitracin solution.

(Bacitracin solution is an extraction and separation solution of a Bacillus subtilis and a B-type Bacillus licheniformis fermentation broth with a potency of no less than 5000 u/ml and conductance of fewer than 2000 μs/cm).

#2. PH Adjustment

An alkaline solution is added to the bacitracin solution to adjust the pH to 8 to 11, add inorganic zinc salt, adjust the pH between 5 to 7 with an inorganic acid, stir for 1 to 2 hours, and let stand for 5 to 10 hours.

(The alkaline solution can be either ammonia water or sodium hydroxide. The inorganic zinc salt is one of zinc oxide, zinc chloride, and zinc sulfate. The inorganic acid is one of hydrochloric acid and sulfuric acid.)

#3. Separation

It is then obtained by separation, drying, pulverization, sieving, and inspection.

The total content of bacitracin A should be greater than 40.0%, the total amount of bacitracin A, B” B2, and B3 should be greater than 70.0%, Potency should be no less than 65IU/MG.

What Are Common Bacitracin Zinc Dosages?

bacitracin zinc ointment

Its common dosage forms include:

Topical Ointment, Strength: 500IU/G [Each gram contains Bacitracin Zinc (equal to 500 bacitracin units)]

Ophthalmic Ointment of 3.5 grams in tubes.

Each gram is equivalent to 500 bacitracin units, polymyxin B sulfate is equivalent to 10,000 polymyxin B units, mineral oil, and white petrolatum.

10 Person First Aid Kit including: Bacitracin zinc (400 [iU]/1g) + Acetaminophen (325 mg/1) + Acetylsalicylic acid (325 mg/1) + Benzalkonium chloride (0.13 g/100g) + Benzalkonium chloride (0.40 mL/100mL) + Benzocaine (6 mL/100mL) + Ethanol (60 mL/100mL) + Ibuprofen (200 mg/1) + Lidocaine (0.5 1/100g) + Neomycin sulfate (5 mg/1g) + Polymyxin B sulfate (5000 [iu]/1g) + Water (98.6 mL/100mL)

Soluble Powder (Bacitracin Zinc Soluble Powder is a mixture of bacitracin zinc and zinc proteinates.

It contains not less than 90.0 percent and not more than 120.0 percent of the labeled amount of having a bacitracin concentration that is nominally bacitracin.)

Ointment for eczema

Ointment with Polymyxin B Sulfate

Topical Aerosol with Polymyxin B Sulfate

Topical Powder with Polymyxin B Sulfate

How To Ship and Store Bacitracin Zinc?

#1. Shipping by Air:

First, it is one of the safest chemicals to be shipped by air.

It is not dangerous, not flammable, not explosive in any way.

We have the certificate of safe air transportation issued by DGM, SRICI, etc.

#2. Storages:

Though bacitracin is an antibiotic, the stability study has found that dry pure bacitracin powder is even stable at temperatures as high as 37 degrees Celsius but decomposes at 56° and 80°.

Aqueous solutions, adjusted to pH 5 to 7 with or without buffers, are stable for several months at refrigerator temperature but lose activity rapidly at room temperature.

Zinc bacitracin is even more stable than bacitracin.

That’s why we can ship it at room temperature.

Just make sure the temperature is not too high.

Also, seal it well to protect it from moisture and light during transportation.

When it has reached your warehouse, store it in a cool, dry, and temperature-stable environment.

Room temperature for its storage is fine, no need to be stored at 2~8° like other antibiotics.

References

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