2-Methoxyestradiol: A Comprehensive Guide
What Is 2-Methoxyestradiol?
2-Methoxyestradiol (2ME2)is a white to off-white crystalline powder insoluble in water but soluble in DMSO and ethanol.
It is the natural metabolite of estradiol and 2-hydroxyestradiol, but it can also be chemically synthesized in the lab with estradiol as the starting material.
2-methoxyestradiol is a small molecule used as an anticancer agent.
It works by preventing the formation of new blood vessels that tumors need to grow (angiogenesis).
It has undergone Phase 1 clinical trials against breast and ovarian cancers.
Preclinical studies suggest that 2-methoxyestradiol could also be effective against inflammatory diseases such as rheumatoid arthritis.
How Does 2-Methoxyestradiol Work?
The mechanisms of action of 2-Methoxyestradiol are multifaceted and continue to be explored by researchers.
Some of the key ways it exerts its effects include:
Inhibition of Tubulin Polymerization:
2-Methoxyestradiol disrupts microtubule formation, which is essential for cell division. By inhibiting tubulin polymerization, it prevents the proliferation of rapidly dividing cancer cells.Anti-Angiogenic Properties:
2-Methoxyestradiol inhibits the formation of new blood vessels (angiogenesis), which is crucial for tumor growth and metastasis. By cutting off the blood supply to tumors, 2-Methoxyestradiol can help slow their progression.Induction of Apoptosis:
2-Methoxyestradiol promotes programmed cell death (apoptosis) in cancer cells, making it a potential candidate for cancer therapy.Anti-Inflammatory Effects:
2-Methoxyestradiol has been shown to reduce inflammation by modulating the activity of inflammatory cytokines and enzymes, such as COX-2.
Potential Benefits and Applications of 2-Methoxyestradiol
The unique properties of 2-Methoxyestradiol have led to its exploration in various therapeutic areas.
Below are some of the most promising applications:
1. Cancer Research
2-Methoxyestradiol has shown significant potential as an anti-cancer agent. Its ability to inhibit tubulin polymerization, suppress angiogenesis, and induce apoptosis makes it a promising candidate for treating various types of cancer, including:
Breast cancer
Prostate cancer
Ovarian cancer
Lung cancer
Research studies have shown that 2-Methoxyestradiol can inhibit tumor growth and metastasis in vitro and in vivo.
2. Cardiovascular Health
2-Methoxyestradiol has been studied for its potential benefits in cardiovascular diseases. It has been shown to:
Reduce vascular inflammation
Inhibit the proliferation of vascular smooth muscle cells
Improve endothelial function
These effects make it a potential therapeutic agent for conditions like atherosclerosis and hypertension.
3. Autoimmune and Inflammatory Diseases
Due to its anti-inflammatory properties, 2-Methoxyestradiol is being explored as a treatment for autoimmune and inflammatory diseases, such as rheumatoid arthritis and lupus.
4. Neuroprotective Effects
Emerging research suggests that 2-Methoxyestradiol may have neuroprotective properties, making it a potential candidate for treating neurodegenerative diseases like Alzheimer’s and Parkinson’s.
How Much Does 2-Methoxyestradiol Cost?
As we have mentioned many times, API prices fluctuate and depend on your order quantity.
Without your order quantity and destination country, we can’t provide an accurate offer; we can only indicate our EX prices for your reference.
If you need less than 1G, please check offers from reagent companies like MCE, adooq, TRC-Canada, etc, as our minimum order quantity starts at 1G.
1G, our EW price is around 250 USD.
If you can order 10G, our price is about 220 USD/G.
For 50G~100G, our offer is 150~200 USD per gram.
For quantities over 200 G, please submit the contact form for a free quote.
Sometimes we may have products on promotion; feel free to contact us about them.
Some customers always complain that your price is too high.
But they don’t know that even the minimum shipping cost for chemicals via FedEx is 50 USD, with a starting gross weight of 500G (1G~500G is charged at the same starting weight).
Shipping chemicals is a different story from shipping a book, etc.
How To Ship 2-Methoxyestradiol API?
Due to the small demand for 2ME2, shipping it by courier or air is preferable. To ship it by sea is not a good idea.
By couriers, we mainly have two shipping options on the table:
1. to ship through our company’s FedEx account:
It means you must handle customs clearance at the destination customs, whether we pay the shipping cost or the freight is to be collected.
If you are not familiar with the clearance procedure, it is better to hire an import broker to do it for you.
2. To ship it through our or your shipping agents:
This way, our agents will help you make door-to-door deliveries; they will handle all the import procedures, and all you need to do is pay extra for their services.
It will be much easier for us to do this through your shipping agents. We would only need to ship the goods to them, and they would take over from there.
Some customers always complain that your price is too high. They don’t know that even the minimum shipping cost for chemicals via FedEx is 50 USD, with a starting gross weight of 500 g (1G~500G is charged at the same starting weight).
Shipping chemicals is a different story from shipping a book, etc.
Contact us to determine a suitable order quantity that makes the order worth the shipping cost.
- 2-MethoxyEstradiol from Wikipedia
- 362-07-2 in PubChem
Disclaimer:
This content is for informational purposes only and is intended for business-to-business communication within the pharmaceutical industry. It is not intended as medical advice. The manufacture, import, and use of API must comply with all applicable laws and regulations in the relevant country or region.
This blog post is informational only and does not constitute medical advice.
Always consult a healthcare professional before starting any new medication or treatment.
