How To Compound Pimobendan Tablets For Dogs?

Pimobendan 74150-27-9 is a widely used pharmaceutical ingredient in veterinary clinics, primarily for dogs with heart failure.

As one of China’s largest pimobendan suppliers and manufacturers, we believe we must share our tablet compounding knowledge with all veterinarians who may need it.

The form above shows the exact ingredient content of each compounded tablet; the amounts vary by dosage.

This is the theoretical ingredient amount meant for each tablet you should compound.

#1. Why You Should Compound Extended-Release Tablets For Dogs

A standard tablet has a short half-life.

Therefore, dogs will suffer from frequent administrations, and the rapid peak rate and high peak concentration will increase the probability of sudden death in sick animals.

If you have extended-release tablets, you can reduce the original twice-daily administration to once daily.

Also, the slow-release tablets can reduce pimobendan peak concentration below the dose that would trigger sudden death.

Meanwhile, the extended-release tablets will also prolong the peak time, achieving better clinical treatment effects, and your pets will get well sooner.

#2. Ingredients for the Extended-Release Tabs (100MG)

Pimobendan (active ingredient, 1mg) + {citric acid, starch, lactose, artificial beef flavoring agent, povidone, colloidal silicon dioxide, magnesium stearate, and other components} (excipients, 99mg).

We have also separated our excipients into several classes below.

#2.1 

Slow-release materials: 1 or a combination of sodium alginate, hydroxypropyl methylcellulose, carbomer (Dosage 5-20% (W/W))

#2.2 

Fillers: Starch and lactose. [10-15% (W/W) for starch, 10-15% (W/W) for lactose]

#2.3 

Binders: Povidone at 2.5% (W/W)

#2.4 

Lubricants: Magnesium stearate at 0.5% (W/W)

#2.5 

Flavor modifiers: One or more combinations of dried liver or muscle powder of cattle, sheep, pigs, poultry, etc., fruit-flavored spices, vanilla spices, preferably chicken liver powder by 6-11% (W/W)

#3. Compounding Procedure

#3.1 

First, you will prepare a pimobendan dispersion in citric acid at a 1:50 ratio.

Then, the pimobendan and citric acid dispersion solids are fully dispersed into the solution.

The solution is vacuum dried, the dried solids are crushed, the solution is sieved through a 200-mesh sieve, and it is set aside for later use.

#3.2 

To make the mixed powder, evenly mix the solid dispersion with slow-release materials (dextrins or cyclodextrins), fillers, 80% Flavor modifiers, and 30% binder.

#3.3 

Obtain soft material by adding the ethanol/water (30/70) binder solution.

Mix the remaining 70% binder in ethanol/water to prepare the solution.

#3.4 

Granulate with the soft material produced above.

Dry the granules at 60°C for 1 hour to obtain uniform granules.

#3.5 

Spread lubricants and the remaining 20% of the flavor modifiers on the granules and mix them well.

#3.6 

Put the flavored granules into tableting machines to obtain the final extended-release tablets.

We wish we could have made the compounding process more thorough, but our current knowledge and experience limit us.

Any experts in tableting processing are welcome to share their knowledge so that others seeking this compounding information can benefit.

For all the Vets, don’t stop here. Using a similar process, you can also compound other sustained-release tablets.

Please comment and contact us if you have better ideas on the compounding processes.

Let’s work together to create a better world for our furry friends.