How To Compound Pimobendan Tablets For Dogs?

Pimobendan 74150-27-9 is a very useful pharmaceutical ingredient used in veterinary clinics, mainly used in dogs with heart failure.

As one of the largest pimobendan suppliers and manufacturers in China, it is our duty and responsibility to share our tablet compounding knowledge with all the veterinaries who may need it

As shown in the form above, you can see the exact ingredient amount in each tablet, the amount differs due to the dosings.

This is the theoretical ingredient amount meant for each tablet you should compound.

#1. Why You Should Compound Extended-Release Tablets For Dogs

If it is a normal tablet rather than an extended-release one, the tablet will have a normal and short half-life.

Therefore, the dogs will not only suffer from frequent administrations but will also increase the probability of sudden death in sick animals due to the rapid peak rate and high peak concentration.

If you have extended-release tablets, you can reduce the original twice-daily administration to once daily.

Also, the slow-release tablets can reduce pimobendan peak concentration below the dose that would trigger sudden death.

Meanwhile, the extended-release tablets will also prolong the peak time, and then achieve better clinical treatment effects and your pets will get well sooner.

#2. Ingredients for the Extended-Release Tabs(100MG)

Pimobendan(Active ingredient 1mg)+{citric acid, starch, lactose, artificial beef orthodontic agent, povidone, colloidal Silicone Dioxide, Magnesium Stearate, and other components}(Excipients 99mg).

We have also separated our excipients into several classes below.

#2.1 Slow-release materials: 1 of or the combination of Sodium alginate, hydroxypropyl methylcellulose, carbomer (Dosage 5-20% (W/W))

#2.2 Fillers: Starch and lactose. [10-15% (W/W) for starch, 10-15% (W/W) for lactose]

#2.3 Binders: Povidone at 2.5% (W/W)

#2.4 Lubricants: Magnesium stearate by 0.5% (W/W)

#2.5 Flavor modifiers: One or more combinations of dried liver or muscle powder of cattle, sheep, pigs, poultry, etc., fruit-flavored spices, vanilla spices, preferably chicken liver powder by 6-11% (W/W)

#3. Compounding Procedure

#3.1 At first, you will prepare the solid dispersion of pimobendan with citric acid by the ratio of 1/50.

Then dissolve pimobendan and citric acid in the water, vacuum dry it, crush the dried solid powder, pass it through a 200 mesh sieve, and put it aside for later use.

#3.2 Mix the solid dispersion with slow-release materials (dextrins or cyclodextrins), fillers, 80% of the Flavor modifiers, and 30% of the binder evenly to get the mixed powder.

#3.3 Get soft material by adding the binder solution of ethanol/water (30/70).

The solution is prepared by mixing the remaining 70% binder in ethanol/water.

#3.4 Make granulates with the soft material produced above.

Dry the granules at 60°C for one hour, and we get even granules.

#3.5 Spread lubricants and the remaining 20% of the flavor modifiers to the granules and mix them well.

#3.6 Put the flavored granules into tableting machines and you get the final extended-release tablets.

We wish we could have made the compounding process more thorough, but we are limited to our bits of knowledge and experiences on it.

Any experts on tableting processing are welcome to share their knowledge so others who are looking for this compounding information will benefit from it.

For all the Vets, don’t stop here. You can also compound other sustained-release tablets with a similar compounding process.

In case you have better ideas on the compounding processes, you are welcome to comment and contact us.

Let’s work together to create a better world for our furry friends.