GMP Approved Bacitracin Powder For Sale
Bacitracin is a mixture of related compounds with different antibacterial activities. Components include bacitracin A, A1, B, B1, B2, C, D, E, F, G, and X. Bacitracin A was found to have the most antibacterial activity. Bacitracin B1 and B2 have similar potencies and are approximately 90% as active as bacitracin A. Other bacitracin components including F and X do not appear to be extensively studied.
Bacitracin GMP & DMF is ready for your MOH registration. Our quality meets USP/EP/CP standards. Bacitracin sample is available for quality approval. We have packing as10kg/Carton. Our MOQ is 1kg. As for lead time, contact us before order.
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What is Bacitracin?
Bacitracin is a white to off-white fluffy powder. It is one of our China GMP-Approved APIs along with USFDA Approval. It is soluble in water, ethanol, and pyridine. Its acidic or neutral aqueous solution is relatively stable. When pH maintains at 5-7, the bacitracin solution is stable for 4 weeks. When solution pH is greater than 9, bacitracin could degrade rapidly at room temperature.
Bacitracin, first isolated in 1945 and later commercially produced, is a mixture of related polypeptides widely used as an antibiotic in injections or topical formulations.
Bacitracin is manufactured by growing the bacteria Bacillus subtilis var Tracy in a container of liquid growth medium in our FDA-audited facility. After fermentation, the bacteria synthesize the antibiotic and secrete the antibiotic into the medium. Then bacitracin is extracted from the medium through chemical processing.
Bacitracin is an effective narrow-spectrum polypeptide with an antibacterial spectrum similar to penicillin and effective against Gram-positive bacteria, some Gram-negative bacteria, spirochetes, and actinomycetes. These polypeptides inhibit Gram-positive bacteria by interfering with the cell wall and peptidoglycan synthesis.
How is bacitracin produced?
Bacitracin is commercially manufactured by growing the bacteria Bacillus subtilis var Tracy I in a container of liquid growth medium. After a certain period, the bacteria synthesize the antibiotic and secrete the antibiotic into the medium. Then the antibiotic is extracted from the medium through chemical processes.
1. Fermentation: use Bacillus subtilis and B. licheniformis to get bacitracin solution. (Bacitracin solution is an extraction and separation solution of a Bacillus subtilis and a B-type Bacillus licheniformis fermentation broth with a potency of no less than 5000 u/ml and a conductance of less than 2000 μs/cm).
2. Adjusting PH value: an alkaline solution is added to the bacitracin solution to adjust the pH as 8 to 11, adjust pH as 5 to 7 with an inorganic acid, stir for 1 to 2 hours, and let stand for 5 to 10 hours.
3. Extraction: bacitracin is then obtained by membrane separation, drying, pulverization, and sieving.
The spray-dried bacitracin powder obtained by processing above can be used as a raw material for medicine preparations such as bacitracin injections and bacitracin polymyxin b ointments.
The total content of bacitracin A is no less than 40.0%, the total amount of bacitracin A, B” B2 and B3 is greater than 70.0%, Potency is no less than 60IU/MG.
What can bacitracin be used for? (bacitracin dosage)
Bacitracin is used for human medicine as a polypeptide antibiotic against infections. Please note, bacitracin should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
Bacitracin is primarily made into ointments as it is can cause kidney damage when used internally.
Bacitracin has been indicated in topical formulations for acute and chronic localized skin infections. It is also used intramuscularly for infantile streptococcal pneumonia and empyema. Bacitracin is also formulated as an ointment with neomycin and polymyxin B as OTC.
Bacitracin ointment formulated with neomycin and polymyxin B along with hydrocortisone is indicated for the treatment of corticosteroid-responsive dermatoses with secondary infection.
Bacitracin can also be used in pure form for those with allergies to the polymyxin B and neomycin components of the combination product.
Bacitracin is also commonly used as an aftercare antibiotic on tattoos and circumcision. It is preferred over combination products such as Neosporin because of its fewer ingredients, which lowers the chances of an allergic reaction.
Although bacitracin’s allergic cross-reaction with sulfa drugs has been occasionally reported, bacitracin-containing topical preparations is a great alternative to silver sulfadiazine (Silvadene) for burn patients with a sulfa allergy.
Bacitracin has been used to distinguish Streptococcus pyogenes from other “strep” bacteria, with S. pyogenes being sensitive to bacitracin and others resistant. In this case, bacitracin is used to distinguish S. pyogenes from other β-hemolytic streptococci.
Bacitracin can be made into testing kits to distinguish Streptococcus pyogenes from other “strep” bacteria, with S. pyogenes being sensitive to bacitracin and others resistant. In this case, bacitracin is used to distinguish S. pyogenes from other β-hemolytic streptococci.
Bacitracin is also used to distinguish Haemophilus influenza colonies amongst respiratory flora; since H. influenza is intrinsically resistant to bacitracin, colonies would form within the zone of inhibition.
Bacitracin vs Mupirocin
Mupirocin is an antibacterial pseudomonic acid antibiotic produced by Pseudomonas fluorescens. It is used for skin infections such as impetigo and traumatic skin lesions such as lacerations, sutured wounds, abrasions caused by susceptible S. aureus and S. pyogenes.
Mupirocin has also been used to treat other primary or secondary superficial skin infections, such as ecthyma, eczema, folliculitis, furunculosis, atopic dermatitis, epidermolysis bullosa, and minor wounds, burns or ulcers.
There are mainly 4 dosage forms of Mupirocin: 1. Mupirocin Calcium Ointment 2. Mupirocin Cream 3. Mupirocin Nasal Ointment 4. Mupirocin Ointment
As we can see above, there are only topical dosage forms for mupirocin while there is no mupirocin injection, no mupirocin eye ointment. Please note: it is very dangerous when mupirocin ointment is applied to eyes and there will be severe symptoms such as burning, tearing. It will take days or even weeks for this uncomfortableness to disappear. (If contact with the eyes occurs, thoroughly wash eyes with water or go to a doctor immediately).
However, there is mupirocin ointment for intranasal use, while there are no bacitracin dosage forms suitable for intranasal uses.
To sum it up, bacitracin is only used for infections caused by susceptible bacteria. Mupirocin is indicated for primary or secondary superficial skin infections.
Bacitracin Side Effects & Contraindications
Side Effects of bacitracin include but not limited to diarrhea, unusual urinating, blood in urine, painful urination and lower back pain.
Other bacitracin reactions include nausea, vomiting, mild skin rash, pain, burning or swelling where bacitracin is injected.
Bacitracin is contraindicated in individuals who have shown hypersensitivity to any of its components.
What is Bacitracin Class?
Bacitracin belongs to the class of organic compounds known as polypeptides. These are peptides containing ten or more amino acid residues. It is classified as other antibiotics with HS Code as 2941909090.
Direct parent: Polypeptides
Alternative Parents: Cyclic peptides / Glutamic acid and derivatives / Leucine and derivatives / Isoleucine and derivatives / N-acyl-alpha amino acids and derivatives / Macrolactams / Alpha amino acid amides / Thiazolecarboxamides / Imidazolyl carboxylic acids and derivatives / Benzene and substituted derivatives
Dicarboxylic acids and derivatives / N-acyl amines / Thiazolines / Heteroaromatic compounds / Secondary carboxylic acid amides / Amino acids / Primary carboxylic acid amides / Lactams / Azacyclic compounds / Carboxylic acids / Propargyl-type 1,3-dipolar organic compounds / Organopnictogen compounds / Carbonyl compounds / Organic oxides / Monoalkylamines / Hydrocarbon derivatives
Superclass: Organic Polymers
Kingdoms: Organic compounds
What is Bacitracin Price? (Last update 2019.12.06)
Fob Shanghai/Beijing price of commercial order quantity pharm-grade bacitracin cost powder is about 680usd/kg.
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